An observational study in Movement Disorders and Lactic Acidosis, sponsored by University Hospital of Split. Completed at 1 site in Croatia. Open to male participants aged 20 Years to 50 Years. Per ClinicalTrials.gov, last updated 2010-06-08.
Sponsored by University Hospital of Split · Observational
Blood lactate levels in patients receiving typical or atypical antipsychotics have not been described in the literature.
The goal of this study is to assess the dynamics of lactate levels in the blood from typical or atypical antipsychotics not confounded by prior antipsychotic treatments, the investigators conducted a prospective study of lactate levels in patients receiving antipsychotic medication. The investigators hypothesized that 6 months of treatment with haloperidol or olanzapine would result in a change in blood lactate levels and extrapyramidal side effects.
The aim of this study was to compare the blood lactate levels in patients receiving typical or atypical antipsychotics.
Subjects included sixty patients with psychotic disorder were assigned to treatment for 6 months with haloperidol (typical antipsychotic), N=30 or olanzapine (atypical antipsychotic), N=30. Blood lactate levels, other metabolic parameters, and scores on the extrapyramidal symptom rating scale (ESRS) were assessed.
320 studies on the registry are indexed under Movement Disorders; 98 are open to participants now.
This study's enrollment of 60 is below the median of 80 across 132 observational studies indexed under Movement Disorders.
Browse Movement Disorders studies →University Hospital of Split is the lead sponsor of 29 studies on the registry; 8 are open to participants now.
Counted across the registry records on this site, refreshed daily.
The population consists of patients from the psychiatric inpatient and outpatient sections of a primary care hospital.
Exclusion Criteria:
Patients were not taking any medications - apart from the prescribed antipsychotic - for a period of 1 month prior to the study with psychotic relapse or newly diagnosed psychotic disorder were recruited from psychiatric inpatient and outpatient clinics of the Split Clinical Hospital.
Drug: Haloperidol or olanzapine
Haloperidol tablet - 5 mg twice daily (morning and evening) by mouth Olanzapine tablet - 5 mg twice daily (morning and evening) by mouth
Also known as: Haldol, Olzapin
Blood lactate levels
Time frame: 1 month
Blood lactate levels
Time frame: 3 months
Blood lactate levels
Time frame: 6 months
Extrapyramidal side effects
The extrapyramidal symptom rating scale (ESRS) was used for assessment of four types of antipsychotic induced movement disorders: parkinsonism, akathisia, dystonia, and tardive dyskinesia referred to as extrapyramidal side effects in this study.
Time frame: 1 month
Extrapyramidal side effects
The extrapyramidal symptom rating scale (ESRS) was used for assessment of four types of antipsychotic induced movement disorders: parkinsonism, akathisia, dystonia, and tardive dyskinesia referred to as extrapyramidal side effects in this study.
Time frame: 3 months
Extrapyramidal side effects
The extrapyramidal symptom rating scale (ESRS) was used for assessment of four types of antipsychotic induced movement disorders: parkinsonism, akathisia, dystonia, and tardive dyskinesia referred to as extrapyramidal side effects in this study.
Time frame: 6 months
This study is completed, as verified in Jun 2010. You cannot join it, but the record below documents what was studied.
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University Hospital of Split