ClinicalTrials.gg
Not yet recruitingNCT07935057osaUpdated Nov 13, 2026

Diaphragmatic Ultrasound and Hypoxic Burden in "Osa"

An observational study in Obstructive Sleep Apnea, sponsored by Assiut University. Not yet recruiting. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-11-13.

Sponsored by Assiut University · Observational

Updated Nov 13, 2026Newly registeredGo to Updates ↓

Help build ClinicalTrials.gg — short surveys, remote interviews or testing, in your language. Take part →

Study type
Observational
Model
Case-only
Time perspective
Cross-sectional
Enrollment
95
Ages
18 Years and older
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-13

Among 13 studies in Sleep Apnea, Obstructive by Assiut University — 7 open to participants now, 7 under way, none of them phase 3. Sleep Apnea, Obstructive · Assiut University.

Planned enrollment
3rd of 11
95 · median 80
Started
2026
with 3 others
Observational
11 of 13
6 open now
Registered
13th of 13
by date

Among the 13 studies in Sleep Apnea, Obstructive by Assiut University, this one is the 3rd largest by planned enrollment of the 11 observational ones that give a count, is one of 4 that started in 2026, is one of 11 observational ones, and was the 13th registered.

Sleep Apnea, Obstructive

2,242 studies on the registry are indexed under Sleep Apnea, Obstructive; 474 are open to participants now.

Browse Sleep Apnea, Obstructive studies →

Open to participants now

7 of the 13 studies in Sleep Apnea, Obstructive by Assiut University are open now. Recruiting first, the newest first:

1 more — sign in →

All 7 open studies →

Where they have run

Who these studies take

Of the 313 Sleep Apnea, Obstructive studies recruiting now, 146 (47%) set no upper age limit and 124 (40%) stop at 75 or younger; 52 take children under 18; 65 take healthy volunteers.

This study: 18 Years and older · all sexes · no healthy volunteers.

The full table on the hub →

This tab as a report to print or save as PDF → With an account.

Was this useful?
Watch this landscapeDownload CSVNarrow it in search →With an account: a weekly mail of what changed among 13 studies in Sleep Apnea, Obstructive by Assiut University, or all of them as a file.
02

Study summary

  • Primary objective To investigate the association between diaphragmatic ultrasound-derived indices, particularly diaphragmatic reserve, and hypoxic burden in patients with OSA.
  • Secondary objectives:

    1. To characterize diaphragmatic thickness, thickening fraction, and excursion in patients with OSA.
    2. To determine the relationship between diaphragmatic ultrasound parameters and polysomnographic parameters as: AHI, ODI, T90, mean SpO₂, minimum SpO₂, REM-AHI, supine AHI, arousal index.
Read the detailed description

Obstructive sleep apnea (OSA) is a serious health condition that has been estimated to affect nearly 936 million adults aged between 30 and 69 worldwide according to recent to recent global estimates.

OSA is therefore a very common condition that results in several health consequences, such as cardiovascular pathology, metabolic disruptions, cognitive decline .

attended Polysomnography (PSG) is considered the gold standard for diagnosis of OSA ,with apnea-hypopnea index (AHI) as the more frequently used indicator of disease severity.

However in recent studies AHI have been shown to be inconsistently related to adverse consequences of OSA Hypoxic burden defined as the sum of individual area under oxygen saturation curves related to every respiratory event obtained by pulse oximeter during the total sleep time, has been suggested as a more accurate measure of OSA severity relating to symptoms and adverse effects.

The diaphragm as the most important muscle of respiration, can impact OSA severity although the extent of such effect is still unclear.

03

Conditions studied

  • Obstructive Sleep Apnea
04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

adult patients who are confirmed to have OSA by polysomnography

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  1. Aged > 18 years.
  2. Newly diagnosed OSA using PSG and meeting AASM diagnostic criteria.
  3. Treatment-naïve with respect to CPAP or other positive-airway-pressure therapy.
  4. Provide .

Exclusion criteria

Exclusion Criteria:

  1. Respiratory diseases:

    Bronchial asthma, , bronchiectasis, interstitial lung disease, neuromuscular respiratory disease

  2. Neurological/diaphragmatic disorders:

    Neuromuscular disorders, muscular dystrophies, previous major thoracic surgery affecting the diaphragm

  3. Other conditions:

decompensated heart failure, significant pulmonary hypertension, active acute respiratory infection

Terms in these criteria, in plain language(3)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

COPD

Chronic obstructive pulmonary disease: long-term lung disease that makes it hard to breathe out, including emphysema and chronic bronchitis.

Cancer (malignancy)

Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.

Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.

05

Study design

Observational model
Case-only
Time perspective
Cross-sectional
Enrollment
95 participants (estimated)
Patient registry
No
06

What researchers measure

Primary outcomes

  1. Establish a correlation between OSA severity and degree of diaphragmatic dysfunction using hypoxic burden related to diaphragmatic ultrasound parameters

    Time frame: Baseline

  2. the association between hypoxic burden and diaphragmatic thickness fraction after adjusted for AHI and BMI

    Time frame: Baseline

07

Study locations

No study locations are listed for this record.

08

References and documents

Publications

  • Bordoni B, Escher AR, Toccafondi A, Mapelli L, Banfi P. Obstructive Sleep Apnea and Role of the Diaphragm. Cureus. 2022 Sep 10;14(9):e29004. doi: 10.7759/cureus.29004. eCollection 2022 Sep. PubMed 36159353 ↗
  • Rundo JV. Obstructive sleep apnea basics. Cleve Clin J Med. 2019 Sep;86(9 Suppl 1):2-9. doi: 10.3949/ccjm.86.s1.02. PubMed 31509498 ↗

Individual participant data

Plan to share: Undecided

09

Timeline

1 registry update since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Start is estimated for Dec 2026; primary completion for Nov 2027, 11 months later.

How these figures are worked out, and which studies are left out of them.

Registered
Oct 27, 2026
First posted
Nov 13, 2026
StartEst.
Dec 1, 2026
Primary completionEst.
Nov 1, 2027
CompletionEst.
Jan 1, 2028
Last update
Nov 13, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
Registered
First appeared on the registry. No changes since
Nov 13, 2026
Show all 1 update
  1. Nov 13, 2026
    First appeared on the registry

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT07935057
Lead sponsor
Assiut University
Responsible party
Abdelrahman Galal Salih (assistant lecturer, Assiut University) — Principal investigator
First posted
Nov 13, 2026
Start date
Dec 1, 2026 (estimated)
Primary completion
Nov 1, 2027 (estimated)
Completion
Jan 1, 2028 (estimated)
Last update
Nov 13, 2026

Study contacts

Abdulrahman Galal Salih, masters degree
Contact
abdogalal231295@gmail.com
00201111532712

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion