An interventional study of Narrow-Band Green Light (NBGL) Filtering Glasses in TBI Traumatic Brain Injury, sponsored by Casa Colina Hospital and Centers for Healthcare. Not yet recruiting at 1 site in United States. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2026-11-12.
Sponsored by Casa Colina Hospital and Centers for Healthcare · Not applicable, Interventional, and Treatment
Among 908 studies in Brain Injuries, Traumatic with a site in United States — 211 open to participants now, 249 under way, 5 of them phase 3. Brain Injuries, Traumatic · United States.
Among the 908 studies in Brain Injuries, Traumatic with a site in United States, this one is the 470th largest by planned enrollment of the 649 interventional ones that give a count, is one of 65 that started in 2026, is one of 440 with no phase, reaches primary completion later than 149 of the 248 other live ones, and was the 908th registered.
1,721 studies on the registry are indexed under Brain Injuries, Traumatic; 447 are open to participants now.
Browse Brain Injuries, Traumatic studies →211 of the 908 studies in Brain Injuries, Traumatic with a site in United States are open now. Recruiting first, the newest first:
Andrew Mayer · Sites in United States
Ages 18–82 · Healthy volunteers
Johns Hopkins University · Sites in United States
Ages 18–55
Columbia University · Sites in United States
Ages 18+
Columbia University · Sites in United States, Brazil, Canada and 2 more countries
Ages 18+
University of Michigan · Sites in United States
Ages 18–65
A study can be open while its sites in United States have not opened yet or have stopped. Only those recruiting at a site in United States →
Of the 281 Brain Injuries, Traumatic studies recruiting now, 120 (43%) set no upper age limit and 119 (42%) stop at 75 or younger; 40 take children under 18; 52 take healthy volunteers.
This study: 18 Years to 70 Years · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
908 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 65 · Phase 2 110 · Phase 3 39 · Phase 4 28
First in 1996; this study’s year is marked. 65 started in 2026.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 20 is below the median of 52 across 1,088 interventional studies indexed under Brain Injuries, Traumatic.
Median enrollment 50 across the 649 interventional studies, 120 across the 257 observational. Of the 553 that completed or were terminated, 182 (33%) have results posted.
This tab as a report to print or save as PDF → With an account.
101 of 908 have an industry lead sponsor. The 10 most frequent:
Casa Colina Hospital and Centers for Healthcare is the lead sponsor of 16 studies on the registry; 11 are open to participants now.
Casa Colina Hospital and Centers for Healthcare has 4 studies filed under Brain Injuries, Traumatic — fewer than ten, so there is no comparison to draw.
83 of the studies in Brain Injuries, Traumatic with a site in United States that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06368648CoMind Technologies LimitedCoMind Early Feasibility Study | 2026-11 |
| NCT06103201University of Maryland, BaltimoreHyperpolarized 13C-pyruvate Metabolic MRI With Traumatic Brain Injury | 2026-11-26 |
| NCT07733284Kessler FoundationHome-Based Walking for Thinking Skills in Persons With TBI | 2026-12 |
| NCT06228391Minneapolis Veterans Affairs Medical CenterKetamine Treatment for PTSD and MDD in TBI | 2026-12 |
| NCT05702138Craig HospitalHigh Intensity Step Training After Traumatic Brain Injury | 2026-12 |
Add all 83 to your calendar (.ics) → With an account.
Among the 908 studies in Brain Injuries, Traumatic with a site in United States, from their registry updates:
This tab as a report to print or save as PDF → With an account.
The purpose of this pilot study is to evaluate whether narrow-band green light filtering glasses improve symptom management and participation in rehabilitation among individuals recovering from traumatic brain injury (TBI). Common post-traumatic symptoms such as photophobia, headaches, difficulty concentrating, anxiety, and sleep disturbances may interfere with engagement in rehabilitation therapies and limit recovery. This study will examine whether use of green light filtering eyewear reduces symptom burden and improves participation in physical, occupational, and speech therapy sessions. Findings will provide preliminary evidence regarding the feasibility and potential clinical utility of green light filtering eyewear as a non-pharmacologic intervention during rehabilitation.
Traumatic brain injury is frequently associated with persistent symptoms including headaches, photophobia, cognitive fatigue, anxiety, and sleep disruption. These symptoms may negatively impact participation in rehabilitation therapies and interfere with functional recovery. Photophobia and headache symptoms are particularly common following TBI and are often exacerbated by indoor lighting and visually stimulating environments. Emerging evidence suggests that exposure to green wavelengths of light may reduce headache severity, improve visual comfort, and decrease neurologic symptom burden in individuals with migraine and other neurologic conditions. Narrow-band green light filtering eyewear is designed to selectively transmit green wavelengths while reducing exposure to other portions of the visible light spectrum that may trigger discomfort. However, little research has examined the use of green light filtering glasses in rehabilitation settings or their potential effect on rehabilitation participation and functional outcomes following TBI. This study seeks to determine whether reducing visual overstimulation through the use of green light filtering eyewear can improve symptom management and facilitate greater engagement in rehabilitation therapies.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants will wear narrow-band green light filtering glasses during the intervention period while receiving standard inpatient traumatic brain injury rehabilitation. The glasses are intended to reduce exposure to selected wavelengths of light and may help reduce symptoms such as headache, photophobia, dizziness, and cognitive fatigue that could interfere with rehabilitation participation.
Device: Narrow-Band Green Light (NBGL) Filtering Glasses
Participants will receive standard inpatient traumatic brain injury rehabilitation without the use of narrow-band green light filtering glasses during the control period. All other aspects of rehabilitation care will remain unchanged.
Participants will wear narrow-band green light filtering glasses during the intervention period while participating in standard inpatient traumatic brain injury rehabilitation. The glasses are designed to filter selected wavelengths of light and are being evaluated for their potential to reduce symptoms commonly experienced after traumatic brain injury, including headache, photophobia (light sensitivity), dizziness, and cognitive fatigue.
Pittsburgh Rehabilitation Participation Scale (PRPS) Score
Therapist-rated rehabilitation participation measured using the Pittsburgh Rehabilitation Participation Scale. Higher scores indicate greater participation in therapy activities.
Time frame: Assessed during each therapy session throughout each intervention period (10 days).
Generalized Anxiety Disorder-7 (GAD-7) Score
Anxiety symptoms measured using the Generalized Anxiety Disorder-7 questionnaire. Higher scores indicate greater anxiety severity.
Time frame: Baseline (Day 0, prior to intervention) and immediately post-intervention (within 72 hours of completion).
Headache Impact Test-6 (HIT-6) Score
Headache-related disability and impact on daily functioning measured using the Headache Impact Test-6. Higher scores indicate greater headache burden.
Time frame: Baseline (Day 0, prior to intervention) and immediately post-intervention (within 72 hours of completion).
Insomnia Severity Index (ISI) Score
Sleep disturbance severity measured using the Insomnia Severity Index. Higher scores indicate greater insomnia severity.
Time frame: Baseline (Day 0, prior to intervention) and immediately post-intervention (within 72 hours of completion).
Neurobehavioral Symptom Inventory (NSI) Total Score
Post-concussive and neurobehavioral symptoms measured using the Neurobehavioral Symptom Inventory. Higher scores indicate greater symptom burden.
Time frame: Baseline (Day 0, prior to intervention) and immediately post-intervention (within 72 hours of completion).
Photosensitivity Assessment Inventory (PSI) Score
Light sensitivity symptoms measured using the Photosensitivity Assessment Inventory. Higher scores indicate greater photosensitivity.
Time frame: Baseline (Day 0, prior to intervention) and immediately post-intervention (within 72 hours of completion).
Plan to share: No — There are no current plans to share individual participant data. The small sample size and potential risk of participant re-identification limit the feasibility of making participant-level data publicly available.
Start is estimated for Nov 2026; primary completion for Oct 2027, 11 months later.
Of 442 non-industry interventional studies with no phase under Brain Injuries, Traumatic, half reached primary completion within 41 months of starting (the median), counting those still running; a quarter within 23 and three quarters within 64. This study's planned 11 months is below that.
Counting every sponsor, half of 464 studies reached it within 40 months; a quarter within 22 and three quarters within 64.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Nov 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Casa Colina Hospital and Centers for Healthcare