An observational study in Gastric Adenocarcinoma and Adenocarcinoma of the Esophagogastric Junction, sponsored by The First Affiliated Hospital with Nanjing Medical University. Not yet recruiting at 2 sites in 2 countries. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2026-09-02.
Sponsored by The First Affiliated Hospital with Nanjing Medical University · Observational
This two-center retrospective observational cohort study compares Chinese and Russian patients who underwent curative proximal gastrectomy with double-tract reconstruction for proximal gastric adenocarcinoma or Siewert type II/III adenocarcinoma of the esophagogastric junction. The study evaluates postoperative reflux, nutritional status, perioperative outcomes, complications, and long-term survival. Propensity score matching will be used to improve comparability between the two cohorts.
83 studies on the registry are indexed under Esophagitis, Peptic; 16 are open to participants now.
This study's planned enrollment of 250 is below the median of 535 across 22 observational studies indexed under Esophagitis, Peptic.
Browse Esophagitis, Peptic studies →The First Affiliated Hospital with Nanjing Medical University is the lead sponsor of 568 studies on the registry; 317 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients treated from June 2015 through June 2025 at either participating center who underwent curative proximal gastrectomy with double-tract reconstruction for proximal gastric adenocarcinoma or Siewert type II/III adenocarcinoma of the esophagogastric junction.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The diagnosis was confirmed by looking at a sample under a microscope: tissue from a biopsy or surgery (histology), or cells from a fluid or needle sample (cytology).
Your pathology report is the document that shows this.
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Histologically or cytologically confirmed
The diagnosis was confirmed by looking at a sample under a microscope: tissue from a biopsy or surgery (histology), or cells from a fluid or needle sample (cytology).
Your pathology report is the document that shows this.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Cancer (malignancy)
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients treated at the First Affiliated Hospital of Nanjing Medical University who underwent proximal gastrectomy with double-tract reconstruction during the study source period.
Procedure: Proximal gastrectomy with double-tract reconstruction
Patients treated at the Moscow Clinical Scientific Center named after A.S. Loginov who underwent proximal gastrectomy with double-tract reconstruction during the study source period.
Procedure: Proximal gastrectomy with double-tract reconstruction
Curative proximal gastrectomy followed by double-tract reconstruction performed as part of routine clinical care. The study does not assign treatment and retrospectively analyzes existing clinical data.
Endoscopic reflux esophagitis
Presence and severity of reflux esophagitis assessed by endoscopy using the Los Angeles classification (grades A-D).
Time frame: 1 year after surgery
Clinically significant reflux symptoms
Reflux symptoms assessed using the GERD-Q questionnaire; a total score greater than 8 is considered clinically significant reflux.
Time frame: 1 year after surgery
Change in body mass index
Change in body mass index, measured in kilograms per square meter.
Time frame: From preoperative baseline to 1 year after surgery
Change in serum albumin
Change in serum albumin concentration, measured in grams per liter.
Time frame: From preoperative baseline to 1 year after surgery
Change in hemoglobin
Change in hemoglobin concentration, measured in grams per liter.
Time frame: From preoperative baseline to 1 year after surgery
Perioperative outcomes-Operative time
Operative time in minutes
Time frame: From surgery through hospital discharge, up to 6 months
Postoperative complications
Overall complications, severe complications defined as Clavien-Dindo grade IIIa or higher, anastomotic leakage, and anastomotic stricture requiring endoscopic dilation or another intervention.
Time frame: Within 30 days after surgery
Overall survival
Time from surgery to death from any cause. Participants alive at last follow-up will be censored.
Time frame: From the date of surgery until death or last follow-up, up to 12 years
Disease-free survival
Time from surgery to first local, regional, or distant recurrence or death from any cause. Event-free participants will be censored at last follow-up.
Time frame: From the date of surgery until recurrence, death, or last follow-up, up to 12 years
intraoperative blood loss
intraoperative blood loss in milliliters
Time frame: from surgery to discharge, up to 6 months
postoperative length of hospital stay
postoperative length of hospital stay in days
Time frame: from surgery to discharge, up to 6 months.
conversion to open surgery
conversion to open surgery among patients undergoing minimally invasive surgery (percentage).
Time frame: from surgery to discharge, up to 6 months
Plan to share: No
No publications or documents are linked to this record.
This study is not yet recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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The First Affiliated Hospital with Nanjing Medical University →