An interventional study of Experimental group: Xanthigen® and Control product in Obesity & Overweight, sponsored by Universidad Católica San Antonio de Murcia. Recruiting at 1 site in Spain. Open to participants aged 20 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-05-07.
Sponsored by Universidad Católica San Antonio de Murcia · Not applicable, Interventional, and Other
Randomized, controlled, triple-blind clinical trial with three parallel arms based on the product consumed (low-dose experimental product, high-dose experimental product, and placebo product) and conducted at a single center to measure the efficacy of a product (Xanthigen®) on overweight or obesity during 16 weeks of consumption.
Participants who meet the inclusion criteria will be included in the study. They will be randomized into three groups, each receiving a dose of the experimental product: 0mg (placebo), 300mg, or 600mg for 16 weeks. The treatment will be administered as a single daily dose in the morning on an empty stomach.
All participants will undergo the same assessments as the active-treatment groups, including anthropometric measurements, physical activity monitoring, and blood tests to evaluate metabolic and biochemical variables. Participants will be asked to maintain their usual dietary and physical activity habits throughout the study.
11,522 studies on the registry are indexed under Obesity; 2,033 are open to participants now.
This study's planned enrollment of 180 is above the median of 67 across 9,006 interventional studies indexed under Obesity.
Browse Obesity studies →Universidad Católica San Antonio de Murcia is the lead sponsor of 138 studies on the registry; 18 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
A recording of the heart’s electrical activity, taken with stickers on the chest, arms and legs. It takes a few minutes and does not hurt.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
A drug or device being studied in a clinical trial.
It may be new, or already approved and being studied for another use, dose or form. Criteria often leave out people who took part in another study of one within a recent period, commonly 30 days or five half-lives.
Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.
Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
ECG (electrocardiogram)
A recording of the heart’s electrical activity, taken with stickers on the chest, arms and legs. It takes a few minutes and does not hurt.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Investigational drug or device
A drug or device being studied in a clinical trial.
It may be new, or already approved and being studied for another use, dose or form. Criteria often leave out people who took part in another study of one within a recent period, commonly 30 days or five half-lives.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraception
Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.
Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants in this arm will receive a placebo identical in appearance and administration schedule to the active product. The treatment will be administered once daily in the morning on an empty stomach.
Dietary Supplement: Control product
Participants assigned to this arm will receive 300 mg of Xanthigen®, administered once daily in the morning on an empty stomach according to the study protocol.
Dietary Supplement: Experimental group: Xanthigen®
Participants in this arm will receive 600 mg of Xanthigen®, administered once daily in the morning on an empty stomach.
Dietary Supplement: Experimental group: Xanthigen®
They will take one capsule per day.
They will take one capsule per day.
Weight
Evaluate the effects of chronic supplementation with two doses (600 and 300mg) of Xanthigen® on weight loss. Body weight refers to the measurement of a person's total mass in kilograms. It is a basic variable that indicates the amount of mass a person has in their body. It will be assessed using the TANITA.
Time frame: It will be measured at the beginning and at least once during the 4 months of consumption.
Body mass index
It is calculated by dividing weight in kilograms by the square of height in meters.
Time frame: It will be measured at the beginning and at least once during the 4 months of consumption.
Waist and hip circumference
Waist circumference refers to the measurement around the narrowest part of the abdominal area, and hip circumference is measured around the most prominent region of the buttocks
Time frame: It will be measured at the beginning and at least once during the 4 months of consumption.
Visceral Adiposity Index (VAI)
The VAI is an index that combines waist circumference, hip circumference, body mass index, and blood triglyceride levels. It provides an estimate of visceral adiposity, which is the fat stored around the internal organs in the abdominal cavity.
Time frame: From the beginning to 16 weeks
Fat mass
It will be measured using dual-energy X-ray absorptiometry (DEXA), which provides an accurate estimate of body composition.
Time frame: It will be measured at the beginning and at least once during the 4 months of consumption.
Changes in body composition
Determine variations in body composition (lean mass and fat mass).
Time frame: From the begynning to 16 weeks
Resting energy expenditure (REE)
Analyze the effect of Xanthigen® supplementation on resting energy expenditure (REE) and its possible significant increase after the intervention.
Time frame: From the beginning to 16 weeks
Blood pressure
It is measured in millimeters of mercury (mm Hg) and recorded as two values: systolic pressure (the pressure when the heart contracts) and diastolic pressure (the pressure when the heart is at rest between beats).
Time frame: It will be evaluated from the start until 16 weeks of consumption.
Serum lipid profile
Assess the effect of the supplement on the lipid profile (total cholesterol, triglycerides, LDL, and HDL).
Time frame: From the begynning to 16 weeks
Effect on glucose metabolism
Analyze the effect of the intervention on glucose metabolism, including fasting glucose and insulin levels and glycosylated hemoglobin (HbA1c).
Time frame: From the begynning to 16 weeks
Plasma ghrelin concentration
Known as the "hunger hormone." It will be evaluated through a blood sample. The unit of measurement will be pg/mL
Time frame: It will be measured at the beginning and after 4 months of consumption.
Plasma leptin concentration
Called the "satiety hormone." It will be evaluated through a blood sample. The unit of measurement will be ng/mL
Time frame: It will be measured at the beginning and after 4 months of consumption.
Plasma adiponectin concentration
A hormone also produced by adipose tissue, but with effects opposite to what one would expect from an adipokine. It will be evaluated through a blood sample. The unit of measurement will be µg/mL
Time frame: It will be measured at the beginning and after 4 months of consumption.
Superoxide dismutase (SOD)
Superoxide dismutase is an antioxidant enzyme that helps protect cells from oxidative damage. SOD levels can be used to assess oxidative stress in the body.
Time frame: It will be measured at the beginning and after 4 months of consumption.
Serum metabolomic profile via metabolite analysis
A comprehensive and systematic study of the metabolites present in a serum sample will be conducted.
Time frame: At 16 weeks after consumption
Psycological General Wellbeing Index (PGWBI)
The PGWBI is a measure of subjective psychological well-being. It assesses self-representations of intrapersonal affective or emotional states that reflect a sense of subjective well-being or ill-being and thus captures what we might call a subjective perception of well-being. It has a range of 0-110; higher scores indicate greater well-being
Time frame: It will be measured at the beginning, after two months, and after four months of consumption.
Three factor eating questionnaire (TFEQ)
The TFEQ is a tool for assessing eating behavior. It measures three dimensions of human eating behavior: cognitive restriction of eating, disinhibition, and hunger. Cognitive restriction, disinhibition, and hunger; range varies by subscale; higher scores indicate a greater presence of the behavior
Time frame: It will be measured at the beginning, after two months, and after four months of consumption.
24-hour dietary record
A 24-hour food record will be conducted to determine changes in participants' food intake. Estimated kcal/day will be recorded.
Time frame: It will be measured at the beginning and after 4 months of consumption.
Physical Exercise Monitoring
The METs performed by the subjects will be evaluated to determine that there are no changes in the physical exercise performed.
Time frame: It will be measured at the beginning and after 4 months of consumption.
Liver safety variables
It is a blood test that measures the presence of some enzymes, proteins and bilirubin in the blood, with the aim of determining if there is any alteration in the liver. Enzyme GPT, GOT, Gamma GT, LDH, alkaline phosphatase and bilirubin (UI/L).
Time frame: It will be evaluated from the start until 16 weeks of consumption.
Adverse events
It will be evaluated at each of the visits.
Time frame: At 16 weeks after consumption
Plan to share: No
No publications or documents are linked to this record.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Universidad Católica San Antonio de Murcia →