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CompletedNCT07533409Updated Sep 9, 2026

Tactile and Pain Sensory Thresholds and Hand Grip Strength

An observational study in Sensation Diminished, Pinprick, Pain and Specific Learning Disorder, With Impairment in Written Expression, sponsored by Sultan 1. Murat State Hospital. Completed at 1 site in Turkey (Türkiye). Open to participants aged 6 Years to 12 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-09.

Sponsored by Sultan 1. Murat State Hospital · Observational

Study type
Observational
Model
Case-control
Time perspective
Cross-sectional
Enrollment
66
Ages
6 Years to 12 Years
Sex
All
01

Study summary

The aim of this study was to compare fingertip tactile sensation, hand and finger grip strength, and hand pain thresholds in children diagnosed with specific learning disorder with impairment in written expression and healthy controls.

02

Conditions studied

  • Sensation Diminished, Pinprick
  • Pain
  • Specific Learning Disorder, With Impairment in Written Expression
03

Who can participate

Ages eligible
6 Years to 12 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

The study will include 33 children diagnosed with specific learning disorder with impairment in written expression and 33 healty control children.

Inclusion Criteria for specific learning disorder with impairment in written expression:

  • Diagnosis of specific learning disorder with impairment in written expression according to the DSM-5 diagnostic criteria
  • Age between 6 and 12 years
  • Clinically normal intellectual functioning
  • Voluntary agreement to participate in the study
  • Absence of any systemic disease
  • Right-hand dominance

Inclusion criteria

Inclusion Criteria for control:

  • Age between 6 and 12 years
  • Clinically normal intellectual functioning
  • Willingness to participate in the study on a voluntary basis
  • Absence of any systemic disease
  • Right-hand dominance

Exclusion Criteria for specific learning disorder with impairment in written expression:

  • Presence of verbal or visual communication problems
  • History of perinatal complications or physical head trauma
  • Presence of psychiatric disorders other than specific learning disorder according to the DSM-5 diagnostic criteria
  • History of known chronic physical or neurological disease (such as cerebral palsy, diabetes, epilepsy, autoimmune disease, liver failure, or kidney failure)
  • Presence of substance or alcohol use disorder
  • Diagnosis of a genetic disorder
  • Previous surgery involving the hand region
  • Presence of infection and/or sensory deficit in the hand region

Exclusion criteria

Exclusion Criteria for control:

  • Presence of any psychiatric disorder according to the DSM-5 diagnostic criteria
  • Presence of verbal or visual communication problems
  • History of perinatal complications or physical head trauma
  • History of known chronic physical or neurological disease (such as cerebral palsy, diabetes, epilepsy, autoimmune disease, liver failure, or kidney failure)
  • Presence of substance or alcohol use disorder
  • Diagnosis of a genetic disorder
  • Previous surgery involving the hand region
  • Presence of infection and/or sensory deficit in the hand region
04

Study design

Observational model
Case-control
Time perspective
Cross-sectional
Enrollment
66 participants (actual)
Patient registry
No

Groups and cohorts

  • Specific learning disorder with impairment in written expression

    The children diagnosed with specific learning disorder with impairment in written expression according to the DSM-5 diagnostic criteria

    Other: Treatment outcome

  • Control

    The healthy children with no known medical condition

    Other: Treatment outcome

Interventions

  • OtherTreatment outcome

    The participants' fingertip light touch and pain sensory thresholds, as well as hand and fingertip pinch strength, will be evaluated.

05

What researchers measure

Primary outcomes

  1. Fingertip light touch

    The participants' light touch sensory thresholds will be assessed using Semmes-Weinstein monofilaments, which consist of calibrated synthetic monofilaments that differ in thickness and the amount of pressure applied. Measurements will be taken from the midpoint of the distal phalanx on the palmar surface of the first, second, and third fingers of the right hand. The test will be performed with the participants' eyes closed; starting with the smallest monofilament, contact will be applied to the test area and progressively larger monofilaments will be used. The test will be terminated when the participant first perceives the touch, and the corresponding value will be recorded.

    Time frame: Baseline

  2. Hand grip strength

    Hand grip strength will be assessed using a Jamar dynamometer (Patterson Medical, Green Bay, WI, USA). During the assessment, the participant will be seated with the shoulders adducted and in neutral rotation, the elbow flexed at 90°, the forearm in a neutral position, and the wrist between 0° and 30° of dorsiflexion. The evaluator will gently support the base of the dynamometer, place it in the participant's hand, and instruct the participant to squeeze as hard as possible. Three measurements of maximum voluntary contraction will be obtained for the right hand, and the highest value will be recorded in kilograms.

    Time frame: Baseline

  3. Finger pinch strength

    The pinch strength between the thumb and index finger of the participants' right hand will be assessed using a Jamar pinch gauge. During the assessment, the shoulder will be in adduction and neutral rotation, the elbow flexed at 90°, the forearm in mid-rotation, and the wrist in a neutral position. The participant will be instructed to squeeze the pinch gauge between the thumb and index finger as hard as possible. Three measurements of maximum voluntary contraction will be obtained for the right hand, and the highest value will be recorded in kilograms.

    Time frame: Baseline

  4. Pressure pain threshold

    The pressure pain threshold will be used to assess the patients' pain perception threshold. Pressure pain threshold will be measured using a manual pressure algometer (Baseline Dolorimeter®). The patients' pain perception thresholds will be measured at the right lateral epicondyle and at the midpoint of the web space between the first and second fingers. During the measurement, the algometer's flat circular probe with a surface area of 1.52 cm² will be placed on the relevant site, and pressure will be increased at a rate of 1 kg/second. The patients will be instructed to indicate the onset of pain by saying "stop" or by raising their hand when they begin to feel slight discomfort. For each reference site, the value will be calculated as the arithmetic mean of two measurements taken 30 seconds apart.

    Time frame: Baseline

06

Study locations

1 site
  • Sultan 1. Murat State Hospital
    Edirne, 22030, Turkey (Türkiye)
07

Registry details

Key details

Study ID
NCT07533409
Lead sponsor
Sultan 1. Murat State Hospital
Responsible party
Alper Mengi (Associate Professor, Sultan 1. Murat State Hospital) — Principal investigator
First posted
Apr 16, 2026
Start date
Apr 10, 2026
Primary completion
Aug 10, 2026
Completion
Sep 4, 2026
Last update
Sep 9, 2026

Study contacts

İbrahim Tiryaki, MD
principal investigator · Sultan 1. Murat State Hospital

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
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