An observational study in Motion Sickness, Somatosensory Disorders and Dizziness, sponsored by Istinye University. Not yet recruiting. Open to participants aged 18 Years to 40 Years. Per ClinicalTrials.gov, last updated 2026-06-26.
Sponsored by Istinye University · Observational
Background: Motion sickness (MS) is a common syndrome characterized by autonomic and behavioral symptoms, such as nausea and dizziness, resulting from exposure to motion stimuli. Its pathophysiology is closely linked to sensory conflict and postural instability theories. While previous studies suggest that postural control, proprioception, and reaction times are affected in individuals susceptible to MS, there is a lack of comprehensive, comparative research evaluating all these parameters concurrently within the same cohort using standardized methods. Objective: This study aims to systematically measure balance, proprioceptive sensitivity, coordination, and reaction time parameters, and quantitatively analyze their relationship with motion sickness severity. Methodology: In this prospective, cross-sectional study, at least 41 participants aged 18-40 with motion sickness will be recruited. Participants will undergo motion sickness susceptibility and severity grading using the Motion Sickness Susceptibility Questionnaire Short Form (MSSQ-SF) and the Graybiel Scale. Objective assessments will include static and dynamic balance testing (ProKin®), knee joint position sense (Clinometer app), manual dexterity and dynamic balance coordination (Nine-Hole Peg Test, Tandem Walk, Romberg Test), and upper/lower extremity reaction time measurements (BlazePod system).
50 studies on the registry are indexed under Motion Sickness; 9 are open to participants now.
Browse Motion Sickness studies →Istinye University is the lead sponsor of 221 studies on the registry; 94 are open to participants now.
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The study population consists of adult individuals aged between 18 and 40 years who exhibit susceptibility to motion sickness.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Participants will undergo a standardized battery of sensorimotor assessments, including static/dynamic balance tracking, knee joint position sense testing, manual dexterity/coordination tasks, and upper/lower extremity reaction time measurements, alongside a controlled motion sickness provocation session using a randomized chair-rotation protocol."
Motion Sickness Severity (Graybiel Score)
Used to grade the clinical severity of acute motion sickness symptoms (including nausea, cold sweating, increased salivation, and dizziness) following a randomized chair-rotation provocation protocol. 0 (Minimum) to 50 points (Maximum). Higher scores indicate greater symptom severity, representing a worse clinical outcome (scores of 16 or above designate frank sickness).
Time frame: 1 hour
Static Balance
Evaluated objectively using the ProKin® computerized balance system. Participants stand on the platform under conditions: double-leg with eyes open.
Time frame: 1 hour
Dynamic Balance Performance
Evaluated using the ProKin® system.
Time frame: 1 hour
Knee Joint Proprioception
Evaluated in supine and prone positions, targeting knee angles of 15°, 30°, 60°, and 90° using the Clinometer digital inclinometer smartphone application.
Time frame: 1 hour
Nine-Hole Peg Test (9HPT) Completion Time
Used to assess upper extremity dexterity and fine motor coordination. Participants place nine pegs into the holes one by one and then remove them as quickly as possible.
Time frame: 1 hour
Tandem Walk Test Error Count
Participants walk barefoot along a straight line for 10 steps, placing the heel of one foot directly against the toe of the other foot with arms relaxed at their sides.
Time frame: 1 hour
Visual Reaction Time
Evaluated using the mobile application-based BlazePod.
Time frame: 1 hour
No study locations are listed for this record.
Start is estimated for Jun 2026; primary completion for Aug 2026, 2 months later.
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This study is not yet recruiting, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.
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