An interventional study of post isometric relaxation and MYOFASCIAL RELEASE in Low Back Pain, Mechanical, Lower Cross Syndrome and Hamstring Muscle Tightness, sponsored by University of Karachi. Recruiting at 1 site in Pakistan. Open to participants aged 18 Years to 45 Years. Per ClinicalTrials.gov, last updated 2026-08-28.
Sponsored by University of Karachi · Not applicable, Interventional, and Treatment
This randomized controlled trial aims to evaluate the combined effects of post-isometric relaxation and myofascial release on pain, flexibility, and functional disability in individuals with low back pain associated with lower cross syndrome. Eligible participants aged 18 to 45 years will be randomly allocated into two parallel intervention groups. One group will receive post-isometric relaxation combined with myofascial release, while the comparison group will receive conventional stretching combined with Therapeutic modalities. Outcomes will be assessed at baseline and after completion of the intervention period. The results of this study are expected to contribute to evidence-based physiotherapy management of low back pain associated with postural imbalance.
2,922 studies on the registry are indexed under Low Back Pain; 580 are open to participants now.
This study's planned enrollment of 60 is close to the median of 60 across 2,364 interventional studies indexed under Low Back Pain.
Browse Low Back Pain studies →University of Karachi is the lead sponsor of 37 studies on the registry; 9 are open to participants now.
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Exclusion Criteria:
Participants in this group will receive post-isometric relaxation combined with myofascial release targeting the hamstring muscles as part of a supervised physiotherapy program.
Other: post isometric relaxation · Other: MYOFASCIAL RELEASE
Participants in this group will receive conventional static hamstring stretching combined with therapeutic modalities, including ultrasound or superficial heat, as part of standard physiotherapy care.
Other: Conventional Static Stretching · Other: Therapeutic Modalities
Post-isometric relaxation will be applied to the hamstring muscles. Participants will be positioned supine with the hip flexed to 90 degrees and will perform a submaximal isometric contraction of the hamstrings against therapist resistance for 5 to 8 seconds, followed by a passive stretch of approximately 10 seconds. The procedure will be repeated three times per limb per session.
Myofascial release will be applied to the hamstring muscles with the participant in a prone position. Sustained manual pressure will be applied along the length of the hamstring muscles using the therapist's hands for approximately 30 seconds per application, repeated multiple times per session to improve tissue extensibility.
Conventional static stretching of the hamstring muscles will be performed with the participant in a supine position. Each stretch will be held for approximately 30 seconds and repeated three times per limb per session as part of routine physiotherapy management.
Therapeutic modalities, including ultrasound therapy or superficial heat application using a heating pad, will be applied prior to stretching to reduce pain and improve tissue extensibility as part of conventional physiotherapy care.
Hamstring Flexibility
Hamstring flexibility will be assessed using Active Knee Extension (AKE) test measured in degrees with a goniometer.
Time frame: Outcome measures will be assessed at baseline, immediately after the first session, after 36 sessions at 12 weeks (3 months), and after 72 sessions at 24 weeks (6 months)
Pain Intensity
Pain intensity will be assessed using the Visual Analogue Scale for Pain, a 10-centimeter scale ranging from 0 to 10, where: 0 = no pain 10 = worst imaginable pain Higher scores indicate worse pain intensity.
Time frame: assessed at baseline, immediately after the first session, after 36 sessions at 12 weeks (3 months), and after 72 sessions at 24 weeks (6 months)
functional flexibility(Straight Leg Raise Test)
Functional flexibility will be assessed using the Straight Leg Raise (SLR) Test, measured in degrees using a goniometer.
Time frame: Outcome measures will be assessed at baseline, immediately after the first session, after 36 sessions at 12 weeks (3 months), and after 72 sessions at 24 weeks (6 months)
Posture Assessment (REEDCO Posture Scale)
Posture will be assessed using the REEDCO Posture Scale, a standardized observational scale used to evaluate body posture. The scale ranges from 0 to 100, where: Lower scores indicate poor posture Higher scores indicate better posture alignment
Time frame: Outcome measures will be assessed at baseline, immediately after the first session, after 36 sessions at 12 weeks (3 months), and after 72 sessions at 24 weeks (6 months)
Plan to share: No — De-identified individual participant data (IPD) collected during this study will not be shared with researchers outside the study team. Data sharing is restricted due to institutional policies, ethical considerations, and the need to protect participant confidentiality. All data will be used solely for academic and research purposes as approved by the institutional review board (IRB).
No publications or documents are linked to this record.
Started Aug 2026 (actual). Primary completion is estimated for Feb 2027, 5 months after the start.
Of 1,231 non-industry interventional studies with no phase under Low Back Pain, half reached primary completion within 11 months of starting (the median), counting those still running; a quarter within 5 and three quarters within 26. This study's planned 5 months is below that.
Counting every sponsor, half of 1,286 studies reached it within 11 months; a quarter within 5 and three quarters within 27.
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University of Karachi