An interventional study of Project EX in Focus of the Study is Smoking Cessation and Prevention and Smoking Prevention, sponsored by University of Karachi. Not yet recruiting at 1 site in Pakistan. Open to participants aged 14 Years to 18 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-26.
Sponsored by University of Karachi · Not applicable, Interventional, and Other
The goal of this intervention is to learn if Project EX helps in prevention and cessation of smoking in adolescents. The main question it aims to answer is:
1. To evaluate whether students in the Project EX Intervention Group would demonstrate immediate, post and six-month effects as compared to Standard Care Control Group
Researchers will compare Intervention Group with compared to Standard Care Control Group to see the effect of intervention.
Participants will receive the intervention Fill pre, post and 6 month follow-up forms.
1,509 studies on the registry are indexed under Smoking; 193 are open to participants now.
This study's planned enrollment of 600 is above the median of 115 across 1,164 interventional studies indexed under Smoking.
Browse Smoking studies →University of Karachi is the lead sponsor of 37 studies on the registry; 9 are open to participants now.
Counted across the registry records on this site, refreshed daily.
The sample selection will be done using following inclusion/ exclusion criteria:
Intervention Group will receive the intervention which is Project EX
Behavioral: Project EX
Standard care control Group will not receive the intervention which is Project EX
Project EX consists of 8 sessions, each 40-45 minutes in length. The lessons are designed to be delivered over a 6 week period. Generally two sessions are provided per week for two weeks, followed by one session per week for the subsequent 4 weeks.
Change from Baseline in Mean motivation to quit tobacco use Score .
Measured with self-report items on the likelihood of motivation to quit in the future. Lower scores indicate greater motivation to quit.
Time frame: Baseline, 6 weeks (post-intervention), and 6 months (follow-up)
Change from Baseline in Mean Smoking Intention Score.
Measured with self-report items on the likelihood of smoking in the future. Lower scores indicate greater intention to smoke.
Time frame: Baseline, 6 weeks (post-intervention), and 6 months (follow-up)
Change from Baseline in Mean Tobacco norm attitude Score
Scale assessing perceived acceptability of tobacco use among peers. Lower scores indicate more favorable attitudes toward tobacco use.
Time frame: Baseline, 6 weeks (post-intervention), and 6 months (follow-up)
Change from Baseline in Mean Self control Score
Scale assessing self control items. Higher scores indicate greater self-control.
Time frame: Baseline, 6 weeks (post-intervention), and 6 months (follow-up)
Change from Baseline in Mean depression Score
Measured with the Center for Epidemiologic Studies Depression Scale (CES-D). Higher scores indicate more depressive symptoms.
Time frame: Baseline, 6 weeks (post-intervention), and 6 months (follow-up)
Change from Baseline in Smoking-Related Knowledge
Measured the health consequences of smoking. Higher scores indicate greater knowledge.
Time frame: Baseline, 6 weeks (post-intervention), and 6 months (follow-up)
Change from Baseline in Endorsement of Tobacco Use Myths
Measured on common misconceptions about tobacco use.
Time frame: Baseline, 6 weeks (post-intervention), and 6 months (follow-up)
Change from Baseline in Tobacco Use Behavior
Measured with self-report items on frequency and amount of tobacco use (cigarettes and other tobacco products) in the past 30 days. Higher scores indicate greater tobacco use.
Time frame: Baseline, 6 weeks (post-intervention), and 6 months (follow-up)
Change from Baseline in Quit Attempts
Measured with self-report items on whether, and how many times, students who use tobacco tried to quit since the previous assessment.
Time frame: Baseline, 6 weeks (post-intervention), and 6 months (follow-up)
Change from Baseline in Coping
Measured with items assessing ways of coping with stress and difficult situations without tobacco use. This scale's items are divided into good coping and bad coping
Time frame: Baseline, 6 weeks (post-intervention), and 6 months (follow-up)
Change from Baseline in Sense of Coherence
Measured with self reported scale assessing the extent to which students see life as comprehensible, manageable, and meaningful.
Time frame: Baseline, 6 weeks (post-intervention), and 6 months (follow-up)
Change from Baseline in Exposure to Tobacco-Related Programming and Tobacco Advertising
Measured with self-report items on exposure to anti-tobacco programs or messages and to pro-tobacco advertisements or promotions. Higher scores indicate greater exposure.
Time frame: Baseline, 6 weeks (post-intervention), and 6 months (follow-up)
Plan to share: Undecided — A decision regarding the sharing of IPD has not yet been made. This will be determined in consultation with the supervisor and will depend on participant consent and the ability to adequately de-identify the data.
Start is estimated for Nov 2026; primary completion for Mar 2027, 4 months later.
Of 401 non-industry interventional studies with no phase under Smoking, half reached primary completion within 26 months of starting (the median), counting those still running; a quarter within 12 and three quarters within 42. This study's planned 4 months is below that.
Counting every sponsor, half of 456 studies reached it within 23 months; a quarter within 8 and three quarters within 40.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
University of Karachi