An observational study in Heat Stroke, sponsored by Second Affiliated Hospital of Wenzhou Medical University. Active, not recruiting at 1 site in China. Per ClinicalTrials.gov, last updated 2026-05-29.
Sponsored by Second Affiliated Hospital of Wenzhou Medical University · Observational
Heat stroke is one of the common acute and critical conditions in the ICU, characterized by a high incidence and mortality rate, and there is still a lack of effective and precise treatment methods. The latest research indicates that G protein-coupled receptor 81 (GPR81), as an endogenous receptor of lactic acid, can regulate immune responses by up-regulating the expression of inflammatory factors and the chemotaxis of neutrophils, suggesting that the GPR81 receptor may play a potential key role in heat stroke. The investigators aim to reveal the position and key role of GPR81 in improving multiple organ dysfunction caused by heat stroke, and to clarify its specific molecular mechanism, with the goal of providing new ideas for the prevention and treatment of heat stroke based on lactate levels, a commonly used clinical indicator.
21 studies on the registry are indexed under Heat Stroke; 10 are open to participants now.
Browse Heat Stroke studies →Second Affiliated Hospital of Wenzhou Medical University is the lead sponsor of 137 studies on the registry; 46 are open to participants now.
Counted across the registry records on this site, refreshed daily.
patients who are diagnosed with heatstroke
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
heatstroke patient, no intervention
The 28-day survival rate of patients with heat stroke
For patients with heat stroke, if they die within 28 days, it indicates they are non-survivors; if they do not die within 28 days, it indicates they are survivors
Time frame: Survival status will be assessed over a period of up to 28 days, starting from the date of hospital admission.
Plasma lactate levels in patients with heat stroke
Collect the plasma lactic acid level each time when patients with heat stroke are hospitalized
Time frame: Plasma lactate levels will be measured at admission and then daily during the hospital stay, for a period of up to 28 days.
Plan to share: Yes — Study protocol and statistical analysis plan.
Supporting information: Statistical analysis plan
Time frame: Beginning 6 months after publication with no end date
Access criteria: Deidentifed participant data underlying the findings wil be made available upon reasonable request. proposls fordata acess should be directedto the corresponding author Shengwei Jin
Data sharing details ↗ · www.wzhealth.com
No publications or documents are linked to this record.
This study is active, not recruiting, as verified in Nov 2025. You cannot join it, but the record below documents what was studied.
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Second Affiliated Hospital of Wenzhou Medical University →