An interventional study of cooling blanket and non-cooling blanket in Heat Stroke, sponsored by Second Affiliated Hospital, School of Medicine, Zhejiang University. Recruiting at 7 sites in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-05-27.
Sponsored by Second Affiliated Hospital, School of Medicine, Zhejiang University · Not applicable, Interventional, and Supportive care
The goal of this clinical trial is to test the cooling effect of cooling blanket in patients with heat stroke. The main questions it aims to answer are:
Participants will accept the cooling blanket or non-cooling blanket according to the randomization group.
Researchers will compare cooling rate and outcomes to see if the cooling blanket can accelerate the cooling speed and improve the prognosis of patients in heat stroke.
21 studies on the registry are indexed under Heat Stroke; 10 are open to participants now.
This study's planned enrollment of 126 is above the median of 34 across 13 interventional studies indexed under Heat Stroke.
Browse Heat Stroke studies →Second Affiliated Hospital, School of Medicine, Zhejiang University is the lead sponsor of 1,047 studies on the registry; 502 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Cooling body temperature by: control the temperature of the emergency room to 20-24℃, 4℃ fluid infusion, ice packs, evaporation, convection, etc.
Device: non-cooling blanket
On the basis of the cooling methods of non-cooling blanket group, combine the cooling blanket to cool down. The cooling blanket is required to be activated within 30min after admission. The blanket temperature will be set at 4-10℃, and the target body temperature is 38℃.
Device: cooling blanket
On the basis of the cooling methods of non-cooling blanket group, combine the cooling blanket to cool down. The cooling blanket is required to be activated within 30min after admission. The blanket temperature will be set at 4-10℃, and the target body temperature is 38℃.
Patients do not receive cooling blanket according to randomization. Cooling body temperature by: control the temperature of the emergency room to 20-24℃, 4℃ fluid infusion, ice packs, evaporation, convection,etc.
0.5-hour temperature reduction
Calculated as the difference between initial core temperature and core temperature at 0.5 hours after admission.
Time frame: 0.5 hours
Body temperature of 0.5 hours
Body temperature of 0.5 hours referred to the temperature value obtained 5 min before and after 0.5 hour.
Time frame: 0.5 hours after admission to emergency department
Body temperature of 2 hours
Body temperature of 2 hours referred to the temperature value obtained 20 min before and after 2 hours.
Time frame: 2 hours
incidence of organ damage
number of participants with organ damage, including but not limited to brain, lung, heart, kidney, liver, and coagulation function
Time frame: up to 90 days
length of ICU stay
The length patient stay at ICU
Time frame: up to 90 days
in-hospital mortality
number of participants dead in-hospital
Time frame: up to 90 days
Started May 2023 (actual). Primary completion is estimated for Oct 2026, 41 months after the start.
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Second Affiliated Hospital, School of Medicine, Zhejiang University →