A Phase 4 interventional study of Ciprofol and propofol in PND and POCD - Postoperative Cognitive Dysfunction, sponsored by Second Affiliated Hospital of Wenzhou Medical University. Enrolling by invitation at 1 site in China. Open to participants aged 65 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-26.
Sponsored by Second Affiliated Hospital of Wenzhou Medical University · Phase 4, Interventional, and Screening
As life expectancy increases, the rate of disability among elderly individuals is also rising. Elderly patients undergoing home-based rehabilitation after surgery without medical supervision may experience complications and adverse events such as nausea, vomiting, or bleeding, which can impair recovery of daily living functions and commonly lead to readmission after discharge-particularly in older adults with multiple comorbidities, declining physical function, or cognitive impairment, who face a higher risk. Postoperative neurocognitive disorder (PND) is common following anesthesia and surgery, affecting up to 65% of adults aged 65 and older, and is associated with significant morbidity and mortality. Most patients do not undergo baseline or follow-up neuropsychological testing during the perioperative period or afterward, limiting the identification and early intervention for PND. With increasing life expectancy and a growing number of elderly patients undergoing surgery, the incidence of PND is expected to continue rising, primarily manifesting as declines in memory, attention, information processing, and cognitive flexibility. Current clinical studies suggest that advanced age, low educational level, pre-existing cognitive impairment, and alcohol and/or substance abuse are strong risk factors for developing PND. The perioperative period represents a critical window for identifying and assessing PND.
270 studies on the registry are indexed under Postoperative Cognitive Complications; 57 are open to participants now.
This study's planned enrollment of 148 is above the median of 110 across 151 interventional studies indexed under Postoperative Cognitive Complications.
Browse Postoperative Cognitive Complications studies →Second Affiliated Hospital of Wenzhou Medical University is the lead sponsor of 137 studies on the registry; 46 are open to participants now.
Counted across the registry records on this site, refreshed daily.
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Exclusion criteria:
Continuous infusion of ciprofol during general anesthesia
Drug: Ciprofol
Drug: propofol
The incidence rate of PND
The primary outcome was the incidence of PND within 24 hours after surgery.
Time frame: At least 1 day before the operation, 4 hours after the operation, and 24 hours after the operation.
The DST score
The changes in DST scores before and after the surgery
Time frame: At least 1 day before the operation, 4 hours after the operation, and 24 hours after the operation.
The MMSE score
The changes in MMSE scores before and after the surgery
Time frame: At least 1 day before the operation, 4 hours after the operation, and 24 hours after the operation.
anesthetic dosage
Time frame: during operation
The TMT-A/B score
Time frame: At least 1 day before the operation, 4 hours after the operation, and 24 hours after the operation.
The BNT score
Time frame: At least 1 day before the operation, 4 hours after the operation, and 24 hours after the operation.
The AVLT-H score
Time frame: At least 1 day before the operation, 4 hours after the operation, and 24 hours after the operation.
the clock drawing test score
Time frame: At least 1 day before the operation, 4 hours after the operation, and 24 hours after the operation.
The QoR-15 score
Time frame: At least 1 day before the operation, 4 hours after the operation, and 24 hours after the operation.
Started Apr 2025 (actual). Primary completion is estimated for Mar 2027, 22 months after the start.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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Studies of the drugs tested here: Ciprofol · Propofol
Postoperative Cognitive Complications →
Second Affiliated Hospital of Wenzhou Medical University →