ClinicalTrials.gg
RecruitingNCT07236684Updated Mar 23, 2026

Identification of Factors Related to UI in Patients With MS and EMG Assessment of PFM Activity

An observational study in Multiple Sclerosis, sponsored by Artvin Coruh University. Recruiting at 1 site in Turkey (Türkiye). Open to female participants aged 30 Years to 50 Years. Per ClinicalTrials.gov, last updated 2026-03-23.

Sponsored by Artvin Coruh University · Observational

From the registry’s dates

  • Started Mar 2026; still recruiting 8 months later.
Study type
Observational
Model
Other
Time perspective
Cross-sectional
Enrollment
47
Ages
30 Years to 50 Years
Sex
Female
01

Where this study stands

Counted across the records on this site · 2026-11-12

Among 307 studies in Multiple Sclerosis with a site in Turkey — 59 open to participants now, 78 under way, 10 of them phase 3. Multiple Sclerosis · Turkey.

Planned enrollment
71st of 103
47 · median 60
Started
2026
with 42 others
Observational
103 of 307
27 open now
Primary completion
2026-09
later than 50 of 77 live
Registered
253rd of 307
by date

Among the 307 studies in Multiple Sclerosis with a site in Turkey, this one is the 71st largest by planned enrollment of the 103 observational ones that give a count, is one of 43 that started in 2026, is one of 103 observational ones, reaches primary completion later than 50 of the 77 other live ones, and was the 253rd registered.

Multiple Sclerosis

3,267 studies on the registry are indexed under Multiple Sclerosis; 662 are open to participants now.

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Open to participants now

59 of the 307 studies in Multiple Sclerosis with a site in Turkey are open now. Recruiting first, the newest first:

53 more — sign in →

All 59 open studies →

A study can be open while its sites in Turkey have not opened yet or have stopped. Only those recruiting at a site in Turkey →

Who these studies take

Of the 430 Multiple Sclerosis studies recruiting now, 163 (38%) set no upper age limit and 211 (49%) stop at 75 or younger; 40 take children under 18; 96 take healthy volunteers.

This study: 30 Years to 50 Years · female.

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02

Study summary

The study aimed to explore the link between urinary incontinence (UI) severity in patients with multiple sclerosis (PwMS), electromyography (EMG) findings, and other relevant factors.

Read the detailed description

The study will consist of a cross-sectional observational analysis involving a cohort of 47 PwMS. The assessment will be employed various instruments, including the Expanded Disability Status Scale (EDSS), Neurogenic Bladder Symptom Score (NBSS), International Consultation on Incontinence Questionnaire Short Form (ICIQ-SF), Incontinence Impact Questionnaire (IIQ-7), International Physical Activity Questionnaire (IPAQ), Fatigue Severity Scale (FSS), EMG.

03

Conditions studied

  • Multiple Sclerosis

Keywords

  • multiple sclerosis
  • electromyography
  • urinary incontinence
  • pelvic floor
  • fatigue
04

Who can participate

Ages eligible
30 Years to 50 Years
Sexes eligible
Female
Sampling method
Non-probability sample

Study population

Women diagnosed with MS will be included in the study.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • having an MS diagnosis according to the 2017 revised McDonald criteria,
  • experiencing symptoms of UI as defined by the International Continence Society (ICS),
  • having an EDSS score below 6.5,
  • PwMS with no communication issues.

Exclusion criteria

Exclusion Criteria:

  • PwMS who did not give consent to participate,
  • those with medication changes in the past 6 months,
  • pregnant PwMS,
  • recent vaginal or caesarean deliveries within 6 months,
  • pelvic organ prolapse,
  • urinary tract infection,
  • recent attack history in the past month.
05

Study design

Observational model
Other
Time perspective
Cross-sectional
Enrollment
47 participants (estimated)
Patient registry
No

Groups and cohorts

  • Patients with Multiple Sclerosis (PwMS)

    Adults diagnosed with multiple sclerosis will be included in the study.

06

What researchers measure

Primary outcomes

  1. Expanded disability status scale (EDSS)

    The Expanded disability status scale (EDSS) will be assessed disability and progression in PwMS, with scores from 0 (normal neurological exam) to 10 (death from MS). Higher scores indicate greater disability.

    Time frame: Single assessment at enrollment

  2. Neurogenic Bladder Symptom Score (NBSS)

    Storage, voiding, and complication symptoms of neurogenic bladder will be assessed with the Neurogenic Bladder Symptom Score (NBSS), a 24-item questionnaire covering incontinence, storage and voiding, and outcomes.

    Time frame: Single assessment at enrollment

  3. International Consultation on Incontinence Questionnaire Short Form (ICIQ-SF)

    The frequency and amount of leakage will be assessed using a six-item scale, and urinary incontinence will be categorised into four groups: mild (1-5), moderate (6-12), severe (13-18) and very severe.

    Time frame: Single assessment at enrollment

  4. Incontinence Impact Questionnaire (IIQ-7)

    Urinary symptoms' impact on daily activities was assessed with the Incontinence Impact Questionnaire (IIQ-7). The 7-item Likert scale has a score range of 0-21, with higher scores reflecting an increased negative impact of incontinence on social functioning, quality of life, and physical activity.

    Time frame: Single assessment at enrollment

  5. Pelvic Floor Muscle Activity

    An electromyography (EMG) device with surface electrodes will be used to assess pelvic floor muscle (PFM) activity. Patients received training beforehand, and measurements were taken noninvasively with two electrodes around the perineum and vagina and one on the inner thigh in women.

    Time frame: Single assessment at enrollment

  6. International Physical Activity Questionnaire (IPAQ)

    The International Physical Activity Questionnaire (IPAQ) assesses the frequency and duration of vigorous, moderate, and walking-like activities over a week. The values are multiplied by factors of 8, 4, and 3.3 Metabolic Equivalent of Tasks, respectively, to help measure overall physical activity. The minimum score for the IPAQ is 0, while there is no theoretically determined maximum score. Higher scores are associated with the individual engaging in a higher level of physical activity.

    Time frame: Single assessment at enrollment

  7. Fatigue severity scale (FSS)

    Fatigue severity scale (FSS) assesses fatigue severity in MS with nine items rated on a 7-point Likert scale. The mean score, adapted to Turkish society, indicates pathological fatigue if it is 4 or higher.

    Time frame: Single assessment at enrollment

07

Study locations

1 of 1 sites recruiting
08

References and documents

Publications

  • Zecca C, Riccitelli GC, Disanto G, Singh A, Digesu GA, Panicari L, Puccini F, Mattioli M, Tubaro A, Gobbi C. Urinary incontinence in multiple sclerosis: prevalence, severity and impact on patients' quality of life. Eur J Neurol. 2016 Jul;23(7):1228-34. doi: 10.1111/ene.13010. Epub 2016 Apr 27. PubMed 27120000 ↗
  • Tornic J, Panicker JN. The Management of Lower Urinary Tract Dysfunction in Multiple Sclerosis. Curr Neurol Neurosci Rep. 2018 Jun 28;18(8):54. doi: 10.1007/s11910-018-0857-z. PubMed 29956001 ↗
  • Afshari P, Abedi P, Majdinasab N, Tafakh S, Haghighizadeh M. Strengths of pelvic floor muscles in women with multiple sclerosis and its relationship with urinary incontinence and quality of life. Front Neurol. 2025 Jan 13;15:1514157. doi: 10.3389/fneur.2024.1514157. eCollection 2024. PubMed 39871990 ↗

Individual participant data

Plan to share: No

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Started Mar 2026 (actual). Primary completion is estimated for Sep 2026, 6 months after the start.

How these figures are worked out, and which studies are left out of them.

Registered
Nov 15, 2025
First posted
Nov 19, 2025
StartActual
Mar 9, 2026
Primary completionEst.
Sep 30, 2026
CompletionEst.
Sep 30, 2026
Last update
Mar 23, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Mar 23, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07236684
Lead sponsor
Artvin Coruh University
Responsible party
Zeynep Yıldız Kızkın (Lecturer, Artvin Coruh University) — Principal investigator
First posted
Nov 19, 2025
Start date
Mar 9, 2026
Primary completion
Sep 30, 2026 (estimated)
Completion
Sep 30, 2026 (estimated)
Last update
Mar 23, 2026

Study contacts

Zeynep Yıldız Kızkın
Contact
pt.zeynepyildiz@gmail.com
5346945085 ext. +90
Zeynep Yıldız Kızkın
principal investigator · Artvin Coruh University

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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