An observational study in Ataxia - Other, Dystonia Disorder and Tremor, Essential, sponsored by Kleber Paiva Duarte. Completed. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-11-17.
Sponsored by Kleber Paiva Duarte · Observational
Electrical stimulation (DBS) through electrodes implanted in the dentate nucleus of the cerebellum for the treatment of tremor intractable with medication, dystonia due to cerebrovascular disease (stroke), sequelae of traumatic brain injury, and ataxia (a disease that causes incoordination of movements). Use of advanced magnetic resonance imaging techniques and recording of nerve cell activity in this nucleus
To establish anatomical and functional criteria, based on stereotactic imaging and electrophysiological recordings, that enable the precise implantation of electrodes in the DN and its efferent projections for the treatment of movement disorders. This study aims to describe a surgical technique for the implantation of deep brain electrodes targeting the stimulation (DBS) of the dentate nucleus (DN) and its efferent projections, supported by the magnetic resonance imaging (MRI), the diffusion tensor imaging (DTI), reformatted in the stereotomographic images and related to stereotactic landmarks and checked with semimicro deep brain recording.
95 studies on the registry are indexed under Dystonic Disorders; 19 are open to participants now.
This study's enrollment of 20 is below the median of 56 across 50 observational studies indexed under Dystonic Disorders.
Browse Dystonic Disorders studies →This is the only study on the registry with Kleber Paiva Duarte as lead sponsor.
Counted across the registry records on this site, refreshed daily.
Patients with dystonia, ataxia or tremor
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Relapsed: the illness came back after treatment had worked. Refractory: it did not respond to treatment, or stopped responding while still on it.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Relapsed and refractory
Relapsed: the illness came back after treatment had worked. Refractory: it did not respond to treatment, or stopped responding while still on it.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Computational dataset
Other: Analytical observation
Analysts observation; CT + MRI + DTI pre and post operative stereotactic coordinates - implants DBS in DN
DSB in the dentate nucleus
All stereotactic image calculations the definitive location of the implants in relation to the targets proposed in the ND, were reanalyzed in a digital environment that included co-registration of the preoperative MRI, DTI, and stereotomograph
Time frame: From enrollment to the end of treatment at 16 weeks
No study locations are listed for this record.
Plan to share: Undecided — There are other projects similar to this one underway. I'd like to be able to connect with other researchers and share our challenges and findings.
Ran from Apr 2016 to primary completion in Nov 2023, 91 months.
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This study is completed, as verified in Nov 2025. You cannot join it, but the record below documents what was studied.
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