ClinicalTrials.gg
RecruitingNCT06996353Updated Jan 9, 2026

Clinical Data Collection of Myopic Patients After PTK-PRK With CZM MEL 90 Excimer Laser

An observational study in Refractive Errors, sponsored by London Vision Clinic. Recruiting at 2 sites in India. Per ClinicalTrials.gov, last updated 2026-01-09.

Sponsored by London Vision Clinic · Observational

From the registry’s dates

  • Started May 2025; still recruiting 1 year 5 months later.
Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
150
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-12

Among 10 studies in Refractive Errors with a site in India — 2 open to participants now, 3 under way, none of them phase 3. Refractive Errors · India.

Started
2025
the only one that year
Observational
Only one
of the 10
Registered
9th of 10
by date
Lead sponsor
1 of 10
London Vision Clinic

Among the 10 studies in Refractive Errors with a site in India, this one is the only one that started in 2025, is the only observational one, and was the 9th registered.

By phase

10 studies; the count open now beside each. This study's row is marked.

No phase9 · 1 open
Observationalthis study1 · 1 open

By the year they started

First in 2008; this study’s year is marked. 1 started in 2025.

Size and results

Median enrollment 682 across the 9 interventional studies, 150 across the 1 observational. Of the 7 that completed or were terminated, 1 (14%) have results posted.

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Watch this landscapeDownload CSVWith an account: a weekly mail of what changed among 10 studies in Refractive Errors with a site in India, or all of them as a file.
02

Study summary

The objective of the clinical investigation presented to is to verify predictions of post-operative PTK-PRK refractive outcome made by the EpiMaster application software by comparing these to post-operative clinical data after routine PTK-PRK treatments.

Read the detailed description

The objective of the clinical investigation presented to is to verify predictions of post-operative PTK-PRK refractive outcome made by the EpiMaster application software by comparing these to post-operative clinical data after routine PTK-PRK treatments.

The EpiMaster application software is not used in this clinical investigation, consequently, it is a merely observational investigation.

03

Conditions studied

  • Refractive Errors

Browse trials for

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patient present with myopic or myopic and astigmatic error

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Inclusion criteria are according to the user manual of CZM MEL 90 Excimer Laser for treatment of refractive errors
  • Patient present with myopic or myopic and astigmatic error
  • Patient will be able to understand the patient information and willing to sign an
  • Patient will be willing to comply with all follow-up visits and the respective examinations

Exclusion criteria

Exclusion Criteria:

  • Exclusion criteria are according to the user manual of CZM MEL 90 Excimer Laser for treatment of refractive errors
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

05

Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
150 participants (estimated)
Patient registry
No

Interventions

  • ProcedurePTK-PRK refractive treatment

    The PTK-PRK refractive treatment will be done according to routine clinical practice.

06

What researchers measure

Primary outcomes

  1. Difference of SE(measured) and SE(predicted by EpiMaster)

    Percentage of eyes with SE6 months post-op "measured" - SEpredicted by EpiMaster within ±1.00D, with SE being the spherical equivalent

    Time frame: 6 months

07

Study locations

2 of 2 sites recruiting
  • Pro Sight Eye Hospital
    Chandigarh, Punjab Haryana 160043, India
    Recruiting
  • Uma Eye Clinic
    Chennai, Tamil Nadu 600040, India
    Recruiting
    • Aadithreya Varman, MD · Contactinfo@umaeyeclinic.in · +91 44 4902 3232
    • Aadithreya Varman, MD, Director of Uma Eye Clinic · Principal investigator
08

References and documents

Individual participant data

Plan to share: No — The plan is to not share IPD.

No publications or documents are linked to this record.

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Started May 2025 (actual). Primary completion is estimated for Nov 2026, 18 months after the start.

Of 35 non-industry observational studies under Refractive Errors, half reached primary completion within 26 months of starting (the median), counting those still running; a quarter within 8 and three quarters within 47. This study's planned 18 months is below that.

Counting every sponsor, half of 42 studies reached it within 19 months; a quarter within 8 and three quarters within 47.

How these figures are worked out, and which studies are left out of them.

Registered
May 21, 2025
First posted
May 30, 2025
StartActual
May 26, 2025
Primary completionEst.
Nov 2026
CompletionEst.
Jun 2027
Last update
Jan 9, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Jan 9, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06996353
Lead sponsor
London Vision Clinic
Collaborators
Optana GmbH
Responsible party
Sponsor
First posted
May 30, 2025
Start date
May 26, 2025
Primary completion
Nov 2026 (estimated)
Completion
Jun 2027 (estimated)
Last update
Jan 9, 2026

Study contacts

Timothy Archer, PhD
Contact
timothy@londonvisionclinic.com
+44 02072241005
Dan Z Reinstein, MD
study director · London Vision Clinic Ltd., London, United Kingdom
Sheetal Brar, MD
principal investigator · Pro Sight Eye Hospital, Chandigarh, India
Aadithreya Varman, MD
principal investigator · Uma Eye Clinic, Chennai, India

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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