An interventional study of Silver diamine Fluoride 38% and LED light curing in Dental Caries, sponsored by Cairo University. Not yet recruiting. Open to participants aged 4 Years to 8 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-29.
Sponsored by Cairo University · Not applicable, Interventional, and Treatment
This randomized clinical trial aims to evaluate and compare the clinical and radiographic performance of 38% silver diamine fluoride (SDF) with 38% silver diamine fluoride followed by light curing in children with carious primary molars.
Children aged 4-8 years with active caries in mandibular primary molars will be included in the study. One group will receive 38% silver diamine fluoride followed by LED light curing, while the comparison group will receive 38% silver diamine fluoride without light curing.
The primary outcome is postoperative pain, assessed using the visual analogue scale (VAS). Secondary outcomes include caries lesion arrest, lesion extension and severity, signs of infection, pain on percussion, pathological tooth mobility, and radiographic changes.
Participants will be followed for 12 months. The findings may help determine whether adding light curing to silver diamine fluoride application improves the management of caries in primary molars.
1,171 studies on the registry are indexed under Dental Caries; 209 are open to participants now.
This study's planned enrollment of 40 is below the median of 60 across 967 interventional studies indexed under Dental Caries.
Browse Dental Caries studies →Cairo University is the lead sponsor of 4,941 studies on the registry; 1,458 are open to participants now.
Of its 37 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Participants will receive topical application of 38% silver diamine fluoride (SDF) without light curing. The solution will be applied to the carious lesion using a microbrush for 1 minute, followed by gentle air drying for 10 seconds and natural drying without light curing
Drug: Silver diamine Fluoride 38%
Participants will receive topical application of 38% silver diamine fluoride (SDF), followed by LED light curing for 20 seconds using a light-curing unit with a wavelength of 420-480 nm and an intensity of 1200-1500 mW/cm².
Drug: Silver diamine Fluoride 38% · Device: LED light curing
Topical application of 38% silver diamine fluoride to carious lesions in primary molars for 1 minute, followed by gentle air drying for 10 seconds, without light curing.
LED light curing applied for 20 seconds after topical application of 38% silver diamine fluoride, using a wavelength of 420-480 nm and an intensity of 1200-1500 mW/cm².
Postoperative pain
Postoperative pain will be assessed using a visual analogue scale (VAS) ranging from 0 to 10, where 0 indicates no pain and 10 indicates the worst pain.
Time frame: At baseline and at 3, 6, 9, and 12 months after treatment.
Caries lesion arrest
Assessment of whether the carious lesion has arrested (yes/no).
Time frame: At baseline and at 3, 6, 9, and 12 months after treatment.
Caries lesion severity (ICDAS)
Assessment of caries lesion severity using ICDAS scores 3-6.
Time frame: At baseline and at 3, 6, 9, and 12 months after treatment.
Caries lesion activity (Nyvad criteria)
Assessment of lesion activity using Nyvad criteria scores 0-9.
Time frame: At baseline and at 3, 6, 9, and 12 months after treatment.
Soft-tissue pathology
Presence or absence of swelling, sinus tract, or fistula.
Time frame: At baseline and at 3, 6, 9, and 12 months after treatment.
Pain on percussion
Presence or absence of pain on percussion.
Time frame: At baseline and at 3, 6, 9, and 12 months after treatment.
Pathological tooth mobility
Presence or absence of pathological mobility.
Time frame: At baseline and at 3, 6, 9, and 12 months after treatment.
Furcation or periapical radiolucency
Presence or absence of furcation or periapical radiolucency on radiographic examination.
Time frame: At baseline, 6 months, and 12 months after treatment.
Widening of the periodontal ligament space
Presence or absence of widening of the periodontal ligament space on radiographic examination.
Time frame: At baseline, 6 months, and 12 months after treatment.
Internal or external root resorption
Presence or absence of internal or external root resorption on radiographic examination.
Time frame: At baseline, 6 months, and 12 months after treatment.
No study locations are listed for this record.
Start is estimated for Nov 2026; primary completion for Nov 2027, 12 months later.
Of 469 non-industry interventional studies with no phase under Dental Caries, half reached primary completion within 15 months of starting (the median), counting those still running; a quarter within 7 and three quarters within 30. This study's planned 12 months is below that.
Counting every sponsor, half of 502 studies reached it within 15 months; a quarter within 7 and three quarters within 29.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Silver diamine fluoride