An interventional study of Sphinx Pose Yoga Therapy in Chronic Low-back Pain (cLBP), sponsored by University of Karachi. Enrolling by invitation at 1 site in Pakistan. Open to participants aged 25 Years to 45 Years. Per ClinicalTrials.gov, last updated 2025-04-04.
Sponsored by University of Karachi · Not applicable, Interventional, and Supportive care
Help build ClinicalTrials.gg — short surveys, remote interviews or testing, in your language. Take part →
Among 223 studies in Low Back Pain with a site in Pakistan — 67 open to participants now, 79 under way, none of them phase 3. Low Back Pain · Pakistan.
Among the 223 studies in Low Back Pain with a site in Pakistan, this one is the 2nd largest by planned enrollment of the 216 interventional ones that give a count, is one of 50 that started in 2025, is one of 216 with no phase, reaches primary completion later than 67 of the 78 other live ones, and was the 142nd registered.
2,923 studies on the registry are indexed under Low Back Pain; 579 are open to participants now.
Browse Low Back Pain studies →67 of the 223 studies in Low Back Pain with a site in Pakistan are open now. Recruiting first, the newest first:
University of Karachi · Sites in Pakistan
Ages 18–45
Riphah International University · Sites in Pakistan
Ages 18–30
Riphah International University · Sites in Pakistan
Ages 25–55
Riphah International University · Sites in Pakistan
Ages 35–50
Riphah International University · Sites in Pakistan
Ages 20–40
A study can be open while its sites in Pakistan have not opened yet or have stopped. Only those recruiting at a site in Pakistan →
Of the 332 Low Back Pain studies recruiting now, 92 (28%) set no upper age limit and 210 (63%) stop at 75 or younger; 8 take children under 18; 46 take healthy volunteers.
This study: 25 Years to 45 Years · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
223 studies; the count open now beside each. This study's row is marked.
First in 2018; this study’s year is marked. 50 started in 2025.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 220 is above the median of 60 across 2,364 interventional studies indexed under Low Back Pain.
Median enrollment 42 across the 216 interventional studies, 180 across the 7 observational. Of the 123 that completed or were terminated, 0 (0%) have results posted.
This tab as a report to print or save as PDF → With an account.
None of the 223 has an industry lead sponsor. The 10 most frequent:
University of Karachi is the lead sponsor of 37 studies on the registry; 9 are open to participants now.
University of Karachi has 6 studies filed under Low Back Pain — fewer than ten, so there is no comparison to draw.
12 of the studies in Low Back Pain with a site in Pakistan that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07645859Dow University of Health SciencesComparison of High-Intensity Interval Training With Moderate-Intensity Continuous Training in Chronic Non-Specific Low Back Pain Patients | 2026-12 |
| NCT06910982University of KarachiYoga and Mindfulness for Chronic Low Back Pain: A Randomized Controlled Trial | 2026-12-30 |
| NCT07912060University of Management and Technology LahoreIntegrated Feldenkrais Method With and Without DNS for Chronic Low Back Pain in Females | 2026-12-31 |
| NCT07912073University of Management and Technology LahoreComparative Effects of Kinetic Control Training and Neural Mobilization in Lumbar Radiculopathy | 2026-12-31 |
| NCT07912047University of Management and Technology LahoreEffects of Spinal Mobilization With and Without Clinical Pilates in Patients With Lumbar Disc Herniationc Herniation | 2026-12-31 |
Add all 12 to your calendar (.ics) → With an account.
Among the 223 studies in Low Back Pain with a site in Pakistan, from their registry updates:
This tab as a report to print or save as PDF → With an account.
Chronic low back pain (CLBP) is a leading cause of disability, significantly impacting quality of life and work productivity. Traditional treatments often provide limited relief, necessitating alternative approaches. This multicenter, parallel-arm, randomized controlled trial (RCT) aims to evaluate the efficacy of Sphinx Pose Yoga Therapy (Yoga), Mindfulness-Based Stress Reduction (MBSR), and their combination in managing CLBP among healthcare providers (HCPs).
Participants will be randomly assigned to one of four groups:
Group A (Yoga Therapy): Sphinx Pose Yoga therapy, practiced three times per week.
Group B (MBSR): Weekly mindfulness meditation, body scan, and gentle stretching.
Group C (Usual Care): Standard treatment guidelines as per The Back Book. Group D (Combined Yoga \& MBSR): Integrated approach, practiced twice per week. The study will assess pain intensity, functional disability, quality of life, physiological markers, mental health, and heart rate variability. Outcomes will be measured at baseline (Week 0), post-intervention (Week 12), and follow-up (Week 24). The trial aims to determine whether Yoga, MBSR, or their combination provides superior benefits over usual care in CLBP management.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
participants will undergo Sphinx Pose Yoga therapy involving gentle stretching exercises aimed at extending the back and activating muscles along the spine. Sessions will be conducted three times per week for 12 weeks.
Behavioral: Sphinx Pose Yoga Therapy
Participants will engage in weekly MBSR sessions, which include mindfulness meditation, body scan exercises, gentle yoga movements, and stress reduction discussions. The intervention will last 12 weeks.
Behavioral: Sphinx Pose Yoga Therapy
Participants will receive usual care as per "The Back Book," which includes standard guidelines for managing chronic low back pain (CLBP) without additional yoga or mindfulness interventions.
Behavioral: Sphinx Pose Yoga Therapy
Participants will receive a combined intervention consisting of Sphinx Pose Yoga therapy and MBSR, integrating elements from both programs. Sessions will be held twice per week for 12 weeks.
Behavioral: Sphinx Pose Yoga Therapy
A structured yoga-based intervention focusing on the Sphinx Pose, aimed at improving spinal flexibility and reducing pain. Participants will perform three sessions per week for 12 weeks.
Pain Intensity
Measured using the Numerical Pain Rating (NPR) scale (0-10).
Time frame: Baseline (Week 0), Post-Intervention (Week 12), Follow-up (Week 24).
Functional Disability
Assessed via the Oswestry Low Back Pain Disability Questionnaire (0-100%).
Time frame: Baseline (Week 0), Post-Intervention (Week 12), Follow-up (Week 24).
Physiological Markers
Cortisol (stress response). β-Endorphins (BE) (pain modulation). Substance-P (SP) (pain neurotransmitter). Interleukin-6 (IL-6) and C-reactive protein (CRP) (inflammation).
Time frame: Baseline (Week 0), Post-Intervention (Week 12), Follow-up (Week 24).
Quality of Life (QoL)
Assessed using WHOQOL-BREF
Time frame: Baseline (Week 0), Post-Intervention (Week 12), Follow-up (Week 24).
Stress Levels
Measured by Sadaf Stress Scale (SSS) - Physical Stress Subscale.
Time frame: Baseline (Week 0), Post-Intervention (Week 12), Follow-up (Week 24).
Depression Symptoms
Evaluated via Beck Depression Inventory (BDI).
Time frame: Baseline (Week 0), Post-Intervention (Week 12), Follow-up (Week 24).
Anxiety Levels
Assessed using Generalized Anxiety Disorder 7 (GAD-7) scale.
Time frame: Baseline (Week 0), Post-Intervention (Week 12), Follow-up (Week 24).
Heart Rate Variability (HRV)
Measured via wearable biofeedback device.
Time frame: Baseline (Week 0), Post-Intervention (Week 12), Follow-up (Week 24).
Plan to share: Yes
Supporting information: Study protocol, Statistical analysis plan, Informed consent form
No publications or documents are linked to this record.
Start is estimated for Apr 2025; primary completion for Dec 2026, 20 months later.
Of 1,231 non-industry interventional studies with no phase under Low Back Pain, half reached primary completion within 11 months of starting (the median), counting those still running; a quarter within 4 and three quarters within 26. This study's planned 20 months is above that.
Counting every sponsor, half of 1,286 studies reached it within 11 months; a quarter within 5 and three quarters within 27.
How these figures are worked out, and which studies are left out of them.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
No contact was published for this record. The registry link below has the sponsor’s details.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
University of Karachi