An interventional study of bariatric surgery in Obesity, Colon Cancer and Thyroid Cancer, sponsored by Universidade Federal de Pernambuco. Not yet recruiting at 1 site in Brazil. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-01-22.
Sponsored by Universidade Federal de Pernambuco · Not applicable, Interventional, and Prevention
The expression of proteins in the blood of obese individuals is different from the expression of proteins in healthy individuals, and is also different in individuals after bariatric surgery. Therefore, this research aims to better understand protein expression in patients indicated for surgical treatment of obesity, evaluating the pre-operative and post-operative status. The objective of this research is to better understand protein expression in patients indicated for surgical treatment of obesity, evaluating the pre-operative and post-surgery status.
The objective of this study is to analyze the Proteomics of obese patients in the preoperative context of bariatric surgery to evaluate which are the up-regulated proteins - potentially related to oncogenic metabolic pathways - and also the down-regulated proteins in the context of obesity - potentially protective in the context of cancer. As well as, evaluate the variation of these proteins, as well as the metabolic pathways with which they are associated, after weight loss promoted by bariatric surgery, in the period of 01 year after this intervention.
The proteomic study will be carried out based on the formation of pools organized based on the patients' pre- and postoperative similarities. Proteomic analyzes will be carried out on a high-performance liquid chromatography system (nanoUPLC) model Acquity Mclass, Waters. Coupled to a Quadrupole Mass Spectrometer-Time of Flight (QToF) Model Sunapt Xs, Waters. Finally, the raw data (raw mass spectra) will be analyzed by the PROGENESIS QI software (Waters) to identify the proteins.
11,522 studies on the registry are indexed under Obesity; 2,033 are open to participants now.
This study's planned enrollment of 103 is above the median of 67 across 9,006 interventional studies indexed under Obesity.
Browse Obesity studies →Universidade Federal de Pernambuco is the lead sponsor of 166 studies on the registry; 22 are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
An analysis was made of patients with severe steatosis, among patients undergoing bariatric surgery
Procedure: bariatric surgery
An analysis was made of patients with severe steatosis, among patients undergoing bariatric surgery
Procedure: bariatric surgery
An analysis was made of patients, among men and women, with insulin resistance, among patients undergoing bariatric surgery
Procedure: bariatric surgery
An analysis was carried out of patients with CRP above the average, among patients undergoing bariatric surgery
Procedure: bariatric surgery
An analysis was made of patients with grade 1 obesity, among patients undergoing bariatric surgery
Procedure: bariatric surgery
An analysis was made of patients with grade 2 obesity, among patients undergoing bariatric surgery
Procedure: bariatric surgery
An analysis was made of patients with grade 3 obesity, among patients undergoing bariatric surgery
Procedure: bariatric surgery
sleeve gastrectomy
Also known as: sleeve gastrectomy
Number of patients with reduced initially upregulated oncogenic proteins
reduction of proteins potentially involved in oncogenic metabolic pathways, initially upregulated in the context of obesity
Time frame: 1 year after bariatric surgery
Plan to share: Undecided — We are still checking pertinent information for sharing
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