An interventional study of MRI-scan in Encephalopathy, Hypoxic-Ischemic, sponsored by Cliniques universitaires Saint-Luc- Université Catholique de Louvain. Active, not recruiting at 1 site in Belgium. Open to participants aged 1 Hour to 14 Months. Per ClinicalTrials.gov, last updated 2025-05-22.
Sponsored by Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Not applicable, Interventional, and Diagnostic
This study is a prospective, observational, single-center study to assess the correlation between rs-fMRI measures and clinical measures of standard MRI, NIRS, EEG and clinical scores.
The target population was neonates with HIE referred to MRI after hypothermia treatment, which was initiated within 6 hours of birth, continued for 72 hours and followed by a slow rewarming period of 6-12 hours.
A one-year clinical and imaging follow-up is planned. As the aim of the present study is to assess the predictiveness of the outcome one year after the HIE event, no follow-up is planned.
Newborns at 36 weeks gestation or more, with HIE treated with therapeutic hypothermia will be prospectively included.
Exclusion Criteria:
Diagnostic Test: MRI-scan
IRM-scan at rest under neonatologist monitoring.
quantifying cerebrovascular reactivity (CVR) by resting-state functional MRI (r-fMRI) in infants with moderate to severe hypoxic-ischaemic encephalopathy (HIE)
Correlation between RCV mapping EEG/MRI
Time frame: at birth, directly after hypothermia and at 1 year of baby's life
Plan to share: No
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This study is active, not recruiting, as verified in May 2025. You cannot join it, but the record below documents what was studied.
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Cliniques universitaires Saint-Luc- Université Catholique de Louvain