ClinicalTrials.gg
RecruitingNCT07703683SARC-ENDOUpdated Jul 14, 2026

Myokines as Potential Biomarkers and Drivers of Sarcopenia in Metabolic and Endocrine Diseases

An observational study in Diabetes, Obesity & Overweight and Cushing Syndrome, sponsored by Cliniques universitaires Saint-Luc- Université Catholique de Louvain. Recruiting at 1 site in Belgium. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-07-14.

Sponsored by Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Observational

From the registry’s dates

  • Started Feb 2026; still recruiting 8 months later.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
100
Ages
18 Years and older
Sex
All
01

Study summary

Prospective, observational, single-center, study evaluating the prevalence of sarcopenia / sarcopenic obesity in individuals with metabolic and / or endocrine diseases, as well as the potential role of myokines as biomarkers or drivers of sarcopenia / sarcopenic obesity in this population.

.

02

Conditions studied

  • Diabetes
  • Obesity & Overweight
  • Cushing Syndrome
  • Metabolic Diseases
  • Endocrine Diseases
  • Sarcopenia
  • Sarcopenic Obesity
03

In context

Diabetes Mellitus

8,290 studies on the registry are indexed under Diabetes Mellitus; 1,077 are open to participants now.

This study's planned enrollment of 100 is below the median of 246 across 1,936 observational studies indexed under Diabetes Mellitus.

Browse Diabetes Mellitus studies →

Lead sponsor

Cliniques universitaires Saint-Luc- Université Catholique de Louvain is the lead sponsor of 350 studies on the registry; 64 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

People with metabolic or endocrine diseases

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Metabolic or endocrine disease

Exclusion criteria

Exclusion Criteria:

  • Known myopathy
  • Systemic use (> 1 mg/kg hydrocortisone) or exogenous Cushing's syndrome
  • Psychological, family, sociological or geographical conditions that could potentially limit compliance with the study protocol
  • History of cancer within the five years prior to the study or Cushing's syndrome due to ACTH-secreting tumor
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Corticosteroids (steroids)

Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.

Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.

05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
100 participants (estimated)
Patient registry
No
Biospecimen retention
Samples with dna

Interventions

  • Participants receive GLP-1 RA or GLP-1/GIP dual agonists as part of their standard care for overweight or obesity

    Also known as: GLP-1/GIP dual agonists

06

What researchers measure

Primary outcomes

  1. Prevalence of sarcopenia / sarcopenic obesity

    Time frame: From February 2026 to december 2056

Secondary outcomes

  1. Myokines levels in serum or plasma

    Myokines levels in serum or plasma as measured by ELISA

    Time frame: February 2026 to December 2056

  2. Myokine expression

    Myokine expression in muscle as measured by RT-qPCR or RNA-Seq

    Time frame: February 2026 to December 2056

  3. Prevalence of MASLD

    MASLD as evaluated by Fibroscan, based on controlled attenuation parameter (CAP, in decibels per meter) as a marker of hepatic steatosis

    Time frame: March 2026 to December 2056

  4. Prevalence of MASH

    Prevalence of MASH as evaluated by Fibroscan, based on Liver stiffness measurement (LSM, in kilopascals) as a surrogate of liver fibrosis

    Time frame: March 2026 to December 2056

07

Study locations

1 of 1 sites recruiting
08

References and documents

Study documents

PDFs hosted by the registry, ClinicalTrials.gov.

Individual participant data

Plan to share: No

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Started Feb 2026 (actual). Primary completion is estimated for Dec 2056, 370 months after the start.

Of 533 non-industry observational studies under Diabetes Mellitus, half reached primary completion within 42 months of starting (the median), counting those still running; a quarter within 16 and three quarters within 175. This study's planned 370 months is above that.

Counting every sponsor, half of 642 studies reached it within 36 months; a quarter within 14 and three quarters within 122.

How these figures are worked out, and which studies are left out of them.

Registered
May 15, 2026
First posted
Jul 14, 2026
StartActual
Feb 19, 2026
Primary completionEst.
Dec 31, 2056
CompletionEst.
Dec 31, 2056
Last update
Jul 14, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Jul 14, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07703683
Responsible party
Sponsor
First posted
Jul 14, 2026
Start date
Feb 19, 2026
Primary completion
Dec 31, 2056 (estimated)
Completion
Dec 31, 2056 (estimated)
Last update
Jul 14, 2026

Study contacts

Laura Orioli, MD, PhD
Contact
laura.orioli@saintluc.uclouvain.be
+32494507621

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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