ClinicalTrials.gg
Status unknownNCT05606185CBCTUpdated Nov 4, 2022

Amount of Root Resorption of Maxillary Anteriors After en Masse Versus Two Step Space Closure

An interventional study of retraction method in Root Resorption, sponsored by Dow University of Health Sciences. Status unknown at 1 site in Pakistan. Per ClinicalTrials.gov, last updated 2022-11-04.

Sponsored by Dow University of Health Sciences · Not applicable, Interventional, and Prevention

The sponsor has not verified this record recently (last verified Oct 2022), so the status shown — last known as Active, not recruiting — may be out of date.

From the registry’s dates

  • Registered 2 years 10 months after the study started (first participant enrolled Dec 2019, registered Oct 2022).
Phase
Not applicable
Study type
Interventional
Enrollment
60
Allocation
Randomized
Sex
All
01

Study summary

The goal of this study is to compare the three dimensional root resorption after extraction space closure in two groups: two step retraction and en masse retraction. Th main aim of this study is to conclude which method is less damaging to the roots.

Participants will be divided into two groups:

  1. En masse retraction (experimental)
  2. Two step retraction (control) Pre retraction and post retraction CBCT scans will be compared for both groups.
02

Conditions studied

  • Root Resorption

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Keywords

  • Two step retraction
  • En masse retraction
  • Cone Beam Computed Tomography
03

In context

Root Resorption

43 studies on the registry are indexed under Root Resorption; 9 are open to participants now.

This study's enrollment of 60 is above the median of 29 across 36 interventional studies indexed under Root Resorption.

Browse Root Resorption studies →

Lead sponsor

Dow University of Health Sciences is the lead sponsor of 179 studies on the registry; 34 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Patients who signed the to be part of this study.
  • Patients with Class I or Class II malocclusion.
  • Patients requiring extractions of maxillary first premolars with absolute anchorage.
  • Good periodontal status.

Exclusion criteria

Exclusion Criteria:

  • Patients who are syndromic or have cleft lip and/or palate.
  • Patients with severe root dilacerations or root canal treated incisors.
  • Patients receiving drugs that alter tooth movement.
  • Patients with systemic disease like endocrinological disorders, vit D excess or deficiency, thyroid or parathyroid problems.
  • Patients with history of trauma to dentition or impacted teeth in anterior maxilla.
  • Patients who have undergone previous orthodontic treatment.
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

05

Study design

Phase
Not applicable
Primary purpose
Prevention
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
60 participants (actual)

Study arms

  • Active comparator
    Two step retraction

    teeth will be retracted in two stages

    Procedure: retraction method

  • Experimental
    En masse retraction

    teeth will be retracted in one stage

    Procedure: retraction method

Interventions

  • Procedureretraction method

    Three dimensional evaluation of root resorption using cone beam computed tomography

06

What researchers measure

Primary outcomes

  1. Root resorption

    Amount of root resorption in three dimensions

    Time frame: 8 months

07

Study locations

1 site
  • Dow University of Health Sciences
    Karachi, Sindh 75530, Pakistan
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 4, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05606185
Responsible party
Hiba Tabassum (Dr, Dow University of Health Sciences) — Principal investigator
First posted
Nov 4, 2022
Start date
Dec 9, 2019
Primary completion
Nov 2022 (estimated)
Completion
Nov 2022 (estimated)
Last update
Nov 4, 2022

Study contacts

HIBA Tabassum, MDS
principal investigator · Dow University of Health Sciences

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Oct 2022. You cannot join it, but the record below documents what was studied.

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