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Enrolling by invitationNCT05414019Updated Apr 25, 2025

Evaluation of Root Resorption Following Different Mandibular Incisors Intrusive Mechanics

An interventional study of Mini-screw and Utility arch in Orthodontic Tooth Movement, Intrusion of Tooth and Resorption, Root, sponsored by Al-Azhar University. Enrolling by invitation at 1 site in Egypt. Open to participants aged 12 Years to 16 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-04-25.

Sponsored by Al-Azhar University · Not applicable, Interventional, and Basic science

From the registry’s dates

  • Primary completion was expected by Jan 2026, 10 months ago, but the record still lists the study as enrolling by invitation.
Phase
Not applicable
Study type
Interventional
Enrollment
21
Allocation
Randomized
Ages
12 Years to 16 Years
Sex
All
01

Study summary

Evaluation of root resorption following different mandibular incisors intrusive mechanics : A randomized clinical trial

02

Conditions studied

  • Orthodontic Tooth Movement
  • Intrusion of Tooth
  • Resorption, Root

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Keywords

  • Intrusion
  • Root resorption
  • Cone beam computed tomography
  • Utility Arch
  • Nitinol reverse curve wire
  • Miniscrew
  • Mandibular incisors
03

In context

Root Resorption

43 studies on the registry are indexed under Root Resorption; 9 are open to participants now.

This study's planned enrollment of 21 is below the median of 29 across 36 interventional studies indexed under Root Resorption.

Browse Root Resorption studies →

Lead sponsor

Al-Azhar University is the lead sponsor of 531 studies on the registry; 172 are open to participants now.

Of its 5 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

Browse Al-Azhar University studies →

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
12 Years to 16 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Patient will be included in this study if has:

    • An age range between 12 and 16 years.
    • Deep overbite with excessive curve of Spee of more than 5mm
    • Over erupted lower incisors.
    • Permanent teeth are all present (except for third molar).
    • No previous orthodontic treatment.
    • No indications or symptoms of periodontal disease in the past or present, as determined by clinical and radiographic examination

Exclusion criteria

Exclusion Criteria:

  • Patients who needed surgery to fix skeletal problems.
  • Any previous trauma or root canal therapy
  • Missing lower incisor.
  • Patients with congenital dentoskeletal disorders
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
21 participants (estimated)

Study arms

  • Active comparator
    Mini-screw

    7 patients will receive an intrusive force delivered by elastics from 2 mini-screws between mandibular lateral incisor and mandibular canine.

    Other: Mini-screw

  • Active comparator
    Utility arch

    7 patients will receive an intrusive force delivered by intrusive utility arch.

    Other: Utility arch

  • Active comparator
    Nitinol reverse curve wire

    7 patients will receive an intrusive force delivered by Nitinol reverse curve wire.

    Other: Nitinol reverse curve wire

Interventions

  • OtherMini-screw

    7 patients will receive an intrusive force delivered by elastics from 2 mini-screws between mandibular lateral incisor and mandibular canine.

  • OtherUtility arch

    7 patients will receive an intrusive force delivered by intrusive utility arch.

  • OtherNitinol reverse curve wire

    7 patients will receive an intrusive force delivered by Nitinol reverse curve wire

06

What researchers measure

Primary outcomes

  1. Linear amount of root resorption

    Cone beam computed tomography linear measurements

    Time frame: Change in Linear Root resorption at 6 months

  2. Volumetric amount of root resorption

    Cone beam computed tomography volumetric measurements

    Time frame: Change in Volumetric Root resorption at 6 months

07

Study locations

1 site
08

References and documents

Publications

  • Goel P, Tandon R, Agrawal KK. A comparative study of different intrusion methods and their effect on maxillary incisors. J Oral Biol Craniofac Res. 2014 Sep-Dec;4(3):186-91. doi: 10.1016/j.jobcr.2014.11.007. Epub 2014 Dec 6. PubMed 25737942 ↗
  • Hamdan AM, Lewis SM, Kelleher KE, Elhady SN, Lindauer SJ. Does overbite reduction affect smile esthetics? Angle Orthod. 2019 Nov;89(6):847-854. doi: 10.2319/030819-177.1. Epub 2019 Jul 15. PubMed 31306077 ↗
  • Piancino MG, Tortarolo A, Di Benedetto L, Crincoli V, Falla D. Chewing Patterns and Muscular Activation in Deep Bite Malocclusion. J Clin Med. 2022 Mar 19;11(6):1702. doi: 10.3390/jcm11061702. PubMed 35330027 ↗
  • Nielsen IL. Vertical malocclusions: etiology, development, diagnosis and some aspects of treatment. Angle Orthod. 1991 Winter;61(4):247-60. doi: 10.1043/0003-3219(1991)0612.0.CO;2. Erratum In: Angle Orthod 1992 Summer;62(2):87. PubMed 1763835 ↗
  • Sonnesen L, Svensson P. Temporomandibular disorders and psychological status in adult patients with a deep bite. Eur J Orthod. 2008 Dec;30(6):621-9. doi: 10.1093/ejo/cjn044. Epub 2008 Aug 5. PubMed 18684706 ↗
  • Guven BA, Ciger S. Evaluation of the Effect of Fixed Anterior Biteplane Treatment on Temporomandibular Joint in Patients with Deep Bite. Turk J Orthod. 2020 Mar 1;33(1):8-12. doi: 10.5152/TurkJOrthod.2020.19108. eCollection 2020 Mar. PubMed 32284893 ↗
  • Millett DT, Cunningham SJ, O'Brien KD, Benson PE, de Oliveira CM. Orthodontic treatment for deep bite and retroclined upper front teeth in children. Cochrane Database Syst Rev. 2018 Feb 1;2(2):CD005972. doi: 10.1002/14651858.CD005972.pub4. PubMed 29390172 ↗
  • Nanda R. The differential diagnosis and treatment of excessive overbite. Dent Clin North Am. 1981 Jan;25(1):69-84. No abstract available. PubMed 6937401 ↗
  • Burstone CR. Deep overbite correction by intrusion. Am J Orthod. 1977 Jul;72(1):1-22. doi: 10.1016/0002-9416(77)90121-x. PubMed 267433 ↗
09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Start is estimated for May 2025; primary completion for Jan 2026, 8 months later.

Of 25 interventional studies with no phase under Root Resorption, half reached primary completion within 21 months of starting (the median), counting those still running; a quarter within 12 and three quarters within 41. This study's planned 8 months is below that.

How these figures are worked out, and which studies are left out of them.

Registered
May 29, 2022
First posted
Jun 10, 2022
StartEst.
May 15, 2025
Primary completionEst.
Jan 2026
CompletionEst.
Jan 2026
Last update
Apr 25, 2025
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Apr 25, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05414019
Lead sponsor
Al-Azhar University
Responsible party
Mahmoud Salah Mahmoud Ali Nassar (Principle investigator, Al-Azhar University) — Principal investigator
First posted
Jun 10, 2022
Start date
May 15, 2025 (estimated)
Primary completion
Jan 2026 (estimated)
Completion
Jan 2026 (estimated)
Last update
Apr 25, 2025

Study contacts

Mahmoud S Nassar, student
principal investigator · Al-Azhar University

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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