An interventional study of Calcium silicate based sealer in Calcium Silicate Based Sealer (CSBS), sponsored by Dow University of Health Sciences. Not yet recruiting at 1 site in Pakistan. Open to participants aged 18 Years to 45 Years. Per ClinicalTrials.gov, last updated 2026-10-08.
Sponsored by Dow University of Health Sciences · Not applicable, Interventional, and Treatment
patients reported at department of Operative dentistry diagnosis section , patients coming to operative department of DIDC-DUHS with the chief complain of moderate to severe pain will be assessed .Complete history of each patient will be obtained along with clinical examination including percussion test, presence of swelling, sinus tract and mobility of tooth. Pulp sensitivity will be assessef. Periapical x-ray will be used to evaluate periapical status PAI score. . Following anesthesia, the tooth will be isolated with a rubber dam to maintain a dry operating field. An access cavity will then be prepared. The presence of bleeding within the pulp chamber will be regarded as an indicator of pulp vitality. The (WL) will be established using patency files . An endodontic motor (eight teeth E-connect) will be programmed for root canal instrumentation. Root canals will be irrigated with sodium hypochlorite (NaOCl). Root canals will be dried using paper points, and will take master cone periapical radiograph before final obturation procedure. For the CSBS group (CERASEAL; Meta Biomed Co., Cheongju, Korea), the sealer will be applied and a single cone will be used for obturation. For the CHBS group (Seal apex), the obturation will be completed via cold lateral condensation. The teeth will be restored with composite (LUNA SDI). Single operator will perform the complete procedure. Analgesic ibuprofen 400 mg (Brufen) will be prescribed to the patient in case of severe pain
Dow University of Health Sciences is the lead sponsor of 171 studies on the registry; 31 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Root canal sealer (CSBS)
Other: Calcium silicate based sealer
Root canal sealer (CHBS)
Other: Calcium silicate based sealer
Root canal sealer used in ENDODONTIC treatment with core material for obturation of root canals
Postoperative pain intensity measured using a Visual Analog Scale (VAS)
Postoperative pain intensity will be assessed using a 10-cm Visual Analog Scale (VAS), ranging from 0 (no pain) to 10 (worst imaginable pain). Participants will record their pain intensity at 6, 24, and 48 hours and at 3 and 7 days after root canal treatment. VAS pain scores at each time point will be recorded and compared between the calcium silicate-based sealer and calcium hydroxide-based sealer groups.
Time frame: 6,24 and 48 hours and after 3 and 7 days
Plan to share: No — IPS will not be shared outside the study team to ensure patient confidentiality and privacy. Data will be used only for the purposes of this study and will remain restricted to the research team.
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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Dow University of Health Sciences