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CompletedNCT05295576Updated Mar 25, 2022

Effect of Non Surgical Periodontal Therapy on Inflammatory Markers in Chronic Periodontitis Patients

An observational study in Aggressive Periodontitis, sponsored by Future University in Egypt. Completed at 1 site in Egypt. Open to participants aged 30 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-03-25.

Sponsored by Future University in Egypt · Observational

Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
50
Ages
30 Years to 60 Years
Sex
All
01

Study summary

The current study was performed to study levels of Il-17 and Il-18 in aggressive periodontitis patients before and after non surgical periodontal therapy

Read the detailed description

Background:host defense factors are involved in pathogenesis of chronic periodontitis so, the current study is assessing levels of Il-17 and Il-18 in chronic periodontitis patients versus periodontally healthy controls.

Subjects and methods: Fifty subjects were included; twenty five of them are diagnosed with chronic periodontitis patients and twenty five are periodontally healthy subjects. Probing depth (PD), clinical attachment level (CAL), plaque index (PI) and gingival index (GI) were recorded for all the enrolled subjects. GCF levels of Il-17 and IL-18 were analyzed by enzyme-linked immunosorbent assay (ELISA).

02

Conditions studied

03

In context

Periodontitis

1,635 studies on the registry are indexed under Periodontitis; 327 are open to participants now.

This study's enrollment of 50 is below the median of 90 across 428 observational studies indexed under Periodontitis.

Browse Periodontitis studies →

Lead sponsor

Future University in Egypt is the lead sponsor of 97 studies on the registry; 26 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
30 Years to 60 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Chronic periodontitis patients

Inclusion criteria

  • Medically free subjects .
  • both genders .
  • age range between 30 to 60 years old .

Exclusion criteria

Exclusion Criteria:

  • Subjects with periodontal surgeries in the last 6 months.
  • Subjects with prior use of antibiotics in the last 6 months.
  • Smokers.
  • Pregnant and lactating females were excluded.
  • Lactating females.
05

Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
50 participants (actual)
Patient registry
No
Biospecimen retention
Samples without dna

Groups and cohorts

  • chronic periodontitis

    scaling and root planing

    Procedure: non surgical periodontal therapy

  • Periodontally healthy individuals

    no treatment

Interventions

  • Procedurenon surgical periodontal therapy

    Scaling and root planing

06

What researchers measure

Primary outcomes

  1. measure levels of Il-17 and Il-18 in chronic periodontitis patients

    measure levels of Il-17 and Il-18 in GCF of chronic periodontitis patients

    Time frame: Change from Baseline Il-17 andIl-18 at 3 months

07

Study locations

1 site
  • Future university in Egypt
    Cairo, 11835, Egypt
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 25, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT05295576
Lead sponsor
Future University in Egypt
Responsible party
Sarah Elkot (Lecturer of Oral Medicine, Periodontology and Diagnosis, Faculty of Oral and Dental Medicine, Future University in Egypt, Cairo, Egypt., Future University in Egypt) — Principal investigator
First posted
Mar 25, 2022
Start date
Mar 27, 2021
Primary completion
Dec 15, 2021
Completion
Dec 30, 2021
Last update
Mar 25, 2022

Study contacts

Sarah M Elkot, Lecturer
principal investigator · Lecturer of Oral Medicine and Periodontology

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 2022. You cannot join it, but the record below documents what was studied.

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