Aggressive Periodontitis clinical trials
The registry lists 63 studies for Aggressive Periodontitis across more than 10 countries. 5 are recruiting or about to start. 47 of them are mainly about Aggressive Periodontitis (how this is decided). Per ClinicalTrials.gov, last updated 2026-08-27.
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Who runs them
Universidade Estadual Paulista Júlio de Mesquita Filho (8) · University of Campinas, Brazil (6) · Kocaeli University (3) · Tanta University (3) · Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (2) · Facultad Nacional de Salud Publica (2) · Damascus University (2) · Future University in Egypt (2)
What is being tested here
Drugs under test in Aggressive Periodontitis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The study
- Dec 2026Single-cell and Spatial Transcriptomic Profiling of Gingival Tissues in Aggressive and Chronic Periodontitis: Deciphering Cellular Heterogeneity and Inflammatory Microenvironment Features · Second Affiliated Hospital, School of Medicine, Zhejiang University
Who these studies take
Of the 4 Aggressive Periodontitis studies recruiting now, 1 (25%) set no upper age limit and 3 (75%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 3 (75%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 3 (75%) | 3 (75%) |
| 30 | 4 (100%) | 4 (100%) |
| 40 | 4 (100%) | 4 (100%) |
| 50 | 2 (50%) | 2 (50%) |
| 65 | 2 (50%) | 2 (50%) |
| 75 | 2 (50%) | 2 (50%) |
| 85 | 1 (25%) | 1 (25%) |
Across all 63 studies, recruiting or not: 79% stop at 75 or younger and 70% at 65; 17% take children; 0% are for women only and 0% for men only; 71% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Aggressive Periodontitis studies take
Of 18 interventional studies with no phase under Aggressive Periodontitis, half reached primary completion within 21 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 21 mo13–37 · 18 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 63. Browse all 63 → or search them.
- A Study to Evaluate the Efficacy and Safety of Bimekizumab in Study Participants With Palmoplantar PustulosisRecruitingNCT07219420Phase 313 countries
- Single-cell and Spatial Transcriptomic Profiling of Gingival Tissues in Aggressive and Chronic Periodontitis: Deciphering Cellular Heterogeneity and Inflammatory Microenvironment FeaturesRecruitingNCT074872721 country
- B Cell Functions in PeriodontitisRecruitingNCT028332851 country
- The Effect of Leukocyte and Platelet-rich Fibrin With Antimicrobial Photodynamic Therapy in Aggressive PeriodontitisRecruitingNCT05043935Not applicable1 country
- Transplantation of Bone Marrow Mesenchymal Stromal Cells for Periodontal RegenerationEnrolling by invitationNCT05975892Phase 1/21 country
- Impact of Periodontitis Grading on Peri-Implant Clinical and Bone Health: A 60-Month Prospective StudyCompletedNCT07671456
- The Effect of Non-Surgical Periodontal Treatment on Systemic Inflammatory Markers and Lipid Profile in Young Adults With Severe PeriodontitisCompletedNCT07526883Not applicable1 country
- Adjunct Use of Diode Laser Therapy and Omega 3 Gel in Local Drug Delivery Approach on The Treatment of Localized Aggressive PeriodontitisCompletedNCT07056257Not applicable1 country
- is Generalized Aggressive Periodontitis an Endless Disease When Does it StopCompletedNCT069706911 country
- Apoptosis Markers in Aggressive PeriodontitisCompletedNCT049840311 country
- Mechanisms and Treatment Response of Aggressive Periodontitis in ChildrenCompletedNCT01330719Not applicable1 country
- Chronic Presence of Epstein Barr Virus in Epithelial Cells From Gingiva is Associated With PeriodontitisCompletedNCT01246596Not applicable1 country
- Subgingival Microbiota Following Mechanical Treatment and it's Effect on Peri-implant Sub-mucosa in Periodontitis PatientsCompletedNCT030902821 country
- Antimicrobial Photodynamic Therapy in Treatment of Aggressive Periodontitis (Stage III, Grade C Periodontitis)CompletedNCT05655338Not applicable
- Long-term Results After Systematic Periodontal TherapyStatus unknownNCT030480451 country
- Non Surgical Periodontal Treatment Effect on Il-17 and Il-18 in Aggressive PeriodontitisCompletedNCT052970841 country
- Effect of Non Surgical Periodontal Therapy on Inflammatory Markers in Chronic Periodontitis PatientsCompletedNCT052955761 country
- Two Different Antibiotic Agents to Treat Generalized Aggressive PeriodontitisCompletedNCT02969928Phase 2/31 country
- Omega-3 Plus Low-dose Aspirin Daily Supplementation in Non-surgical Therapy to Treat Aggressive PeriodontitisCompletedNCT03093246Phase 2/31 country
- Efficacy of GBT vs SRP+US, in the Treatment of Severe Generalized Periodontitis.CompletedNCT05112471Not applicable1 country
- Diode Laser With Periodontal Flap Surgery in PeriodontitisCompletedNCT05108727Not applicable
- Concentrated Growth Factors in Treatment of Intrabony Defects in Localized Aggressive PeriodontitisCompletedNCT05001919Phase 1/21 country
- Nigella Sativa Oil Extract and Xenograft Bone Graft in Treatment of Infra-bony DefectsStatus unknownNCT04722380Phase 21 country
- Omega-3 Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Aggressive PeriodontitisCompletedNCT03093207Phase 2/31 country
- Chairside Mouthrinse Test and Cost EffectivenessStatus unknownNCT04139863Not applicable1 country
- Evaluation of Efficacy of Full-mouth Disinfection in Generalized Aggressive Periodontitis PatientsCompletedNCT02466646Phase 4
- Interaction Between Immune Cells and Bacteria Associated With PeriodontitisCompletedNCT032259501 country
- Efficacy of Sub-gingival Air-polishing With Erythritol in the Treatment of PeriodontitisCompletedNCT04264624Not applicable1 country
- IL-34 Levels in Various Types of PeriodontitisCompletedNCT04223869Not applicable
- Influence of Smoking on Clinical, Microbiological and Immunologic Parameters in Patients With Aggressive Periodontitis.Status unknownNCT04051255Not applicable1 country
- Evaluation of Possible Genes in Periodontal Diseases by Genetic MethodsStatus unknownNCT04026828
- GCF HIF-1α, VEGF and TNF-α Levels in G-AgP Patients Before and After Periodontal Treatment.CompletedNCT04020315Not applicable1 country
- EMD for Treatment of Proximal Class-II Furcation InvolvementsCompletedNCT03320135Not applicable1 country
- Efficacy of Three Antibiotic Protocols for Aggressive Periodontitis TreatmentStatus unknownNCT02839421Phase 41 country
- Amoxicillin and Metronidazole in Association With Non-surgical Therapy in Aggressive Periodontitis TreatmentCompletedNCT03933501Phase 4
- Metagenomic and Immune-inflammatory Analysis of Individuals With Generalized Aggressive Periodontitis and Their Descendants.CompletedNCT03933514
- Alternative Antibiotic Regime in the Treatment of GAgPCompletedNCT02223702Phase 41 country
- Doxycycline in the Treatment of Aggressive PeriodontitisCompletedNCT03727620Phase 1/21 country
- Clinical, Immunological and Microbiological Evaluation of Experimental Gingivitis and Peri-implant MucositisCompletedNCT03713567Not applicable1 country
- Enamel Matrix Proteins in the Treatment of Intrabony Defects in Patients With Aggressive and Chronic PeriodontitisCompletedNCT03025204Phase 41 country
- Active Matrix Metalloproteinase-8 (aMMP-8) Chair-side Test in Different Periodontal DiseaseCompletedNCT03527901
- Analysis of Osteoimmune Interactions Linking Inflammation and Bone Destruction in Aggressive PeriodontitisTerminatedNCT01993368Not applicable1 country
- Effects Of Adjunctive Photodynamic Therapy To Non-Surgical Periodontal Treatment In Patients With Generalized Aggressive PeriodontitisCompletedNCT03412331Not applicable
- Perforated Collagen Membrane With Nanohydroxyapatite for Intrabony DefectsCompletedNCT03399279Not applicable
- Clarithromycin as Adjuvant to Periodontal DebridementCompletedNCT02829983Not applicable
- Clinical and Radiographic Evaluation of Guided Tissue Regeneration With Radiation-sterilized Allogenic Bone Grafts or Xenogenic Grafts for the Treatment of Intrabony Defects in Aggressive PeriodontitisStatus unknownNCT03340012Not applicable1 country
- Comparison Between Surgical Access and Repeated Applications of APDTStatus unknownNCT03140059Not applicable
- Immediate Implant Placement in Aggressive PeriodontitisStatus unknownNCT03218228Not applicable1 country
- Estimation of Pentrexin-3 Levels in GCF and Saliva of Patients With Periodontal DiseaseCompletedNCT03128502
- Nonsurgical Periodontal Treatment Associated or Not With Systemic Antibiotics and Photodynamic TherapyCompletedNCT03142776Not applicable