An observational study in Craniofacial Fibrous Dysplasia, sponsored by Centre Hospitalier Universitaire de Nice. Not yet recruiting at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-13.
Sponsored by Centre Hospitalier Universitaire de Nice · Observational
Fibrous dysplasia is a rare bone disorder in which normal bone is replaced by fibro-osseous tissue. Craniofacial involvement may be associated with substantial morbidity and complex multidisciplinary care. CRANIO-DF aims to describe morbidity, management and outcomes in adults with craniofacial fibrous dysplasia using the French national EasyHYBRID-DF database.
CRANIO-DF is a national, multicenter, retrospective observational study based exclusively on secondary use of data already collected in HYBRID-DF. Adults with fibrous dysplasia and documented craniofacial involvement will be included. No additional data will be collected from medical records. The study will describe disease characteristics, associated manifestations, bone-targeted treatments, fractures, neurological compressions, deformities, surgical procedures, malignant transformation, endocrine events and digestive/hepatobiliary-pancreatic abnormalities when available. The primary objective is to estimate the frequency of patients with at least one documented morbid event or manifestation during follow-up. Secondary objectives are to characterize these events, describe medical and surgical management, and explore factors associated with morbidity.
Centre Hospitalier Universitaire de Nice is the lead sponsor of 722 studies on the registry; 176 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Adults with fibrous dysplasia and documented craniofacial involvement recorded in the French national EasyHYBRID-DF database, including monostotic craniofacial disease and polyostotic disease involving the craniofacial skeleton.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Other: No Intervention: Observational Cohort
No Intervention
Presence of at least one documented morbid event or manifestation
Binary outcome (yes/no): presence of at least one morbid event or manifestation documented in HYBRID-DF during available follow-up, including relevant bone, neurological, surgical, malignant, endocrine or other recorded morbidity.
Time frame: Up to 10 years
Nature of documented morbid events or manifestations
Nature of events/manifestations, number of events per patient, time to event when a date is available, and recurrence/progression when recorded.
Time frame: Up to 10 years
Burden of documented morbid events or manifestations
Burden of events/manifestations, number of events per patient, time to event when a date is available, and recurrence/progression when recorded.
Time frame: Up to 10 years
Disease management
Type and duration of bone-targeted and/or surgical treatments
Time frame: Up to 10 years
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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Craniofacial Fibrous Dysplasia
Centre Hospitalier Universitaire de Nice →