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SuspendedNCT07388394POLYVIHUpdated Sep 2, 2026

Polypharmacy on Healthy Aging in People Living With HIV Over the Age of 75

An interventional study of interview with advanced practice nurse in Virus-HIV, sponsored by Centre Hospitalier Universitaire de Nice. Suspended at 1 site in France. Open to participants aged 75 Years and older. Per ClinicalTrials.gov, last updated 2026-09-02.

Sponsored by Centre Hospitalier Universitaire de Nice · Not applicable, Interventional, and Other

Why this study was suspended
The inclusions have been suspended pending approval of an amendment to the protocol
Phase
Not applicable
Study type
Interventional
Enrollment
136
Allocation
Not applicable
Ages
75 Years and older
Sex
All
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Study summary

Since the advent of antiretroviral treatments, the life expectancy of people living with HIV (PLHIV) has increased significantly. In France, more than 30% of PLHIV are now over 50 years old. This population is exposed to high multimorbidity, leading to frequent polypharmacy, defined as the regular use of at least five medications. Polypharmacy also has a qualitative dimension, including potentially inappropriate prescriptions. It increases the risk of adverse effects and drug interactions and impairs quality of life. A coordinated geriatric approach is therefore essential to optimize care. Healthy aging, promoted by the WHO, aims to improve the lives of older people. In this context, a study will be conducted at the Nice University Hospital among PLHIV aged 75 and over. It will collect quantitative data, the results of which will enable us to consider, if necessary, adapting the care pathways of these patients whose needs are complex.

02

Conditions studied

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In context

Acquired Immunodeficiency Syndrome

2,040 studies on the registry are indexed under Acquired Immunodeficiency Syndrome; 272 are open to participants now.

This study's planned enrollment of 136 is above the median of 105 across 1,543 interventional studies indexed under Acquired Immunodeficiency Syndrome.

Browse Acquired Immunodeficiency Syndrome studies →

Lead sponsor

Centre Hospitalier Universitaire de Nice is the lead sponsor of 709 studies on the registry; 176 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
75 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • HIV-positive
  • Aged 75 or over
  • Affiliated with the social security system
  • Having expressed no objection to participating in the study

Exclusion criteria

Exclusion Criteria:

  • Refusal to participate
  • Known severe cognitive impairment preventing the interview from being conducted
  • Patient under guardianship or conservatorship
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Study design

Phase
Not applicable
Primary purpose
Other
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
136 participants (estimated)

Study arms

  • Other
    people living with HIV over the age of 75

    Other: interview with advanced practice nurse

Interventions

  • Otherinterview with advanced practice nurse

    45 to 60 minutes of interview

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What researchers measure

Primary outcomes

  1. Describe polypharmacy among people living with HIV aged 75 and older.

    The average number of medications taken

    Time frame: 15 months

Secondary outcomes

  1. Assess the most common comorbidities associated with polypharmacy in the population of PLHIV aged 75

    Number et type of comorbidities

    Time frame: 15 months

  2. Assess whether people taking multiple medications have a lower treatment adherence score than those taking fewer medications.

    Score obtained on the Morisky MMAS-8 questionnaire

    Time frame: 15 months

  3. Assess the level of functional independence in this age group and link it to the existence of polypharmacy.

    Lawton and Brody IADL scale

    Time frame: 15 months

07

Study locations

1 site
  • CHU de NICE
    Nice, CHU de Nice, France
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References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 2, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07388394
Lead sponsor
Centre Hospitalier Universitaire de Nice
Responsible party
Sponsor
First posted
Feb 5, 2026
Start date
Jan 28, 2026
Primary completion
May 31, 2027 (estimated)
Completion
May 31, 2027 (estimated)
Last update
Sep 2, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is suspended, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.

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