Preterm Premature Rupture of the Membranes clinical trials
The registry lists 20 studies for Preterm Premature Rupture of the Membranes across 7 countries. 10 are recruiting or about to start. Per ClinicalTrials.gov, last updated 2026-10-27.
Keep track of what changes. Save the Preterm Premature Rupture of the Membranes studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesWho runs them
Washington University School of Medicine (2) · Indian Council of Medical Research (1) · The University of Texas Medical Branch, Galveston (1) · Manisa Celal Bayar University (1) · Yuzuncu Yil University (1) · Erzincan Military Hospital (1) · Odense University Hospital (1) · Assistance Publique - Hôpitaux de Paris (1)
What is being tested here
Drugs under test in Preterm Premature Rupture of the Membranes studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Who these studies take
Of the 8 Preterm Premature Rupture of the Membranes studies recruiting now, 5 (63%) set no upper age limit and 3 (38%) stop at 75 or younger. 4 (50%) take children under 18. 7 (88%) are for women only and 0 (0%) for men only; 2 (25%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (25%) | 0 (0%) |
| 18 | 7 (88%) | 0 (0%) |
| 30 | 7 (88%) | 0 (0%) |
| 40 | 7 (88%) | 0 (0%) |
| 50 | 7 (88%) | 0 (0%) |
| 65 | 5 (63%) | 0 (0%) |
| 75 | 5 (63%) | 0 (0%) |
| 85 | 5 (63%) | 0 (0%) |
Across all 20 studies, recruiting or not: 45% stop at 75 or younger and 45% at 65; 25% take children; 95% are for women only and 0% for men only; 30% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 6, 2026.
Started recruiting1
Newly registered1
- Preterm Parturation StudyOct 9, 2026NCT07869160
Studies
Recruiting first, then most recently updated. Showing 20 of 20. search them.
- Selective Antibiotics When Symptoms Develop Versus Universal Antibiotics for Preterm NeonatesRecruitingNCT06377397Phase 31 country
- Preterm Parturation StudyNot yet recruitingNCT078691601 country
- Effects of Emotional Freedom Technique and Music Therapy in High-Risk PregnancyRecruitingNCT07559071Not applicable1 country
- Extended Azithromycin Treatment in Prelabor Rupture of MembranesRecruitingNCT07669207Phase 41 country
- TAILORED Therapeutic Regime in Patients With Preterm Premature Rupture Of Membranes to Prolong Pregnancy, Improve Maternal and Neonatal Outcomes, and Reduce Antibiotic BurdenRecruitingNCT07107477Phase 31 country
- PPROM Registry (Preterm Premature Rupture of Membranes)RecruitingNCT029973451 country
- Improvement of PPROM Management With Prophylactic Antimicrobial Therapy (iPROMPT)RecruitingNCT06396078Phase 41 country
- Digital vs. Speculum Exams for PPROMRecruitingNCT05773014Not applicable1 country
- Antenatal Breastmilk Expression in Pregnant Women at High Risk of Preterm BirthNot yet recruitingNCT07191366Not applicable
- Oxytocin/Foley vs. Oxytocin for Induction in Patients With PPROMRecruitingNCT07119398Phase 41 country
- Erythromycin Versus Azithromycin for Preterm Prelabor Rupture of MembranesActive, not recruitingNCT06273891Phase 31 country
- Does a Rescue Course of Betamethasone in Pregnant Women With PPROM Decrease Neonatal Morbidity?TerminatedNCT02939742Phase 2/31 country
- Tocolysis in the Management of Preterm Premature Rupture of Membranes Before 34 Weeks of GestationActive, not recruitingNCT03976063Phase 31 country
- Simultaneous Mifepristone and Misoprostol Versus Misoprostol Alone for Induction of Labor of Nonviable Second Trimester Pregnancy: a Pilot Randomized Controlled TrialCompletedNCT05322252Phase 41 country
- Biochemical and Histological Changes in Pregnant Women With Preterm Premature Rupture of MembraneCompletedNCT066399191 country
- The Psychological Experience of Pathological Pregnancy. Study of the Case of Premature Rupture of Membranes and Evaluation of the Impact of Hypnosis SupportCompletedNCT05353153Not applicable1 country
- Effects of Different Antibiotic Regimens in Preterm Premature Rupture of MembranesCompletedNCT07148622Not applicable1 country
- Vaginal Probiotics During Pregnancy After Premature Rupture of MembranesWithdrawnNCT06878443Not applicable1 country
- Indomethacin Versus Placebo in Women With Preterm Premature Rupture of Membranes (PPROM)Status unknownNCT00466128Phase 21 country
- Does Vitamins C and E Supplementation of After Preterm Rupture of Membranes Prolong the Duration of Latency? A Prospective Randomized Controlled StudyCompletedNCT01266928Phase 31 country