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CompletedNCT04276324Updated Oct 23, 2020

Effects of Ten-Weeks Power Training on Neuromuscular Performance, Heart Rate Variability, Sleep Quality and Mobility in Persons With Multiple Sclerosis

An interventional study of Resistance training and Testing sessions in Multiple Sclerosis, sponsored by Universidad Católica San Antonio de Murcia. Completed at 1 site in Spain. Open to participants aged 20 Years to 60 Years. Per ClinicalTrials.gov, last updated 2020-10-23.

Sponsored by Universidad Católica San Antonio de Murcia · Not applicable, Interventional, and Supportive care

Phase
Not applicable
Study type
Interventional
Enrollment
36
Allocation
Randomized
Ages
20 Years to 60 Years
Sex
All
01

Study summary

Multiple Sclerosis (ME) is a degenerative, inflammatory and autoimmune demyelinating disease of the central nervous system, characterized by demyelination due to inflammation and degeneration of the myelin sheaths enveloping nerves of the eye, periventricular grey matter, brain, spinal cord and brainstem. The symptoms associated with MS include symptomatic fatigue, muscle weakness, ataxia, mobility and balance problems or cognitive problems. Strength training has been shown to improve strength and mobility in persons with MS.

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Conditions studied

  • Multiple Sclerosis
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In context

Multiple Sclerosis

3,460 studies on the registry are indexed under Multiple Sclerosis; 661 are open to participants now.

This study's enrollment of 36 is below the median of 50 across 2,342 interventional studies indexed under Multiple Sclerosis.

Browse Multiple Sclerosis studies →

Lead sponsor

Universidad Católica San Antonio de Murcia is the lead sponsor of 132 studies on the registry; 18 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
20 Years to 60 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • mild or moderate disability with clinical mild spastic-ataxic gait disorder.
  • stable phase of the disease.

Exclusion criteria

Exclusion Criteria:

  • Expanded Disability Status Scale (EDSS) \< 6.
  • relapsing disease within the preceding 12 months.
  • corticosteroid treatment within the last months before study inclusion.
05

Study design

Phase
Not applicable
Primary purpose
Supportive care
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
36 participants (actual)

Study arms

  • Active comparator
    Control Group

    Only testing sessions

    Other: Testing sessions

  • Experimental
    Resistance training group

    Ten weeks of resistance training

    Other: Resistance training · Other: Testing sessions

Interventions

  • OtherResistance training

    Ten weeks of resistance training

  • OtherTesting sessions

    Testing sessions

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What researchers measure

Primary outcomes

  1. Maximal Voluntary Isometric Contraction of Knee Extension

    Time frame: Before the program training

  2. Maximal Voluntary Isometric Contraction of Knee Extension

    Time frame: After 10 weeks

  3. Rate of Force Development

    Time frame: Before the program training

  4. Rate of Force Development

    Time frame: After 10 weeks

  5. Central Activation Ratio

    Time frame: Before the program training

  6. Central Activation Ratio

    Time frame: After 10 weeks

  7. Spasticity

    Pendulum test

    Time frame: Before the program training

  8. Spasticity

    Pendulum test

    Time frame: After 10 weeks

Secondary outcomes

  1. Walking speed

    Test 10 m-walks

    Time frame: Before the program training

  2. Walking speed

    Test 10 m-walks

    Time frame: After 10 weeks

  3. Static balance

    Romberg Test with eyes open and closed. Analysis with force plates

    Time frame: Before the program training

  4. Static balance

    Romberg Test with eyes open and closed. Analysis with force plates

    Time frame: After 10 weeks

  5. Functional capacity

    Sit to stand test

    Time frame: Before the program training

  6. Functional capacity

    Sit to stand test

    Time frame: After 10 weeks

  7. Heart Rate Variability

    Sleeping Heart Rate Variability

    Time frame: Before the program training

  8. Heart Rate Variability

    Sleeping Heart Rate Variability

    Time frame: After 10 weeks

  9. Sleep Quality

    Karolinska Sleep Diary and Acelerometry

    Time frame: Before the program training

  10. Sleep Quality

    Karolinska Sleep Diary and Acelerometry

    Time frame: After 10 weeks

07

Study locations

1 site
  • Universidad Católica San Antonio
    Murcia, 30107, Spain
08

References and documents

Individual participant data

Plan to share: Yes — The data will be published in a journal

Supporting information: Study protocol, Sap, Icf, Csr

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 23, 2020, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT04276324
Lead sponsor
Universidad Católica San Antonio de Murcia
Responsible party
Jacobo Á. Rubio (Principal Investigator, Universidad Católica San Antonio de Murcia) — Principal investigator
First posted
Feb 19, 2020
Start date
Mar 10, 2020
Primary completion
Jun 15, 2020
Completion
Oct 15, 2020
Last update
Oct 23, 2020

Study contacts

Jacobo Á Rubio-Arias, Dr
principal investigator · Universidad Católica San Antonio de Murcia

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2020. You cannot join it, but the record below documents what was studied.

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