Sclerosis clinical trials
The registry lists 37 studies for Sclerosis across more than 10 countries. 9 are recruiting or about to start. 7 of them are mainly about Sclerosis (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Status
Who runs them
Gilead Sciences (2) · Hope Biosciences Research Foundation (2) · National Institute of Allergy and Infectious Diseases (NIAID) (2) · Merck KGaA, Darmstadt, Germany (2) · Centre Hospitalier Universitaire de Saint Etienne (1) · Contineum Therapeutics (1) · Century Therapeutics, Inc. (1) · Massachusetts General Hospital (1)
What is being tested here
Drugs under test in Sclerosis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Cyclophosphamide | 1 | 1 | 2 |
| Acetylcysteine | 1 | 0 | 1 |
| Diosmin | 1 | 0 | 1 |
| Fludarabine | 1 | 0 | 1 |
| Tocilizumab | 1 | 0 | 1 |
| Vimseltinib | 1 | 0 | 1 |
| Metformin | 0 | 0 | 1 |
| Bosentan | 0 | 0 | 1 |
| PIPE-791 | 0 | 0 | 1 |
| Simtuzumab | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 4
- Feb 2027Metformin Add-on Clinical Study in Multiple Sclerosis to Evaluate Brain Remyelination And Neurodegeneration · University Hospital, Antwerp
- Mar 2027Zero CDE Technique for Lens Removal During FLACS · Bochner Eye Institute
- Jul 2027Physiological Effects of N-Acetyl Cysteine in Patients With Multiple Sclerosis · Thomas Jefferson University
- Jul 2027Study of Diosmin for the Treatment of Digital Ulcers in Systemic Sclerosis · Primus Pharmaceuticals
Who these studies take
Of the 5 Sclerosis studies recruiting now, 3 (60%) set no upper age limit and 1 (20%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 5 (100%) | 5 (100%) |
| 30 | 5 (100%) | 5 (100%) |
| 40 | 5 (100%) | 5 (100%) |
| 50 | 5 (100%) | 5 (100%) |
| 65 | 4 (80%) | 4 (80%) |
| 75 | 4 (80%) | 4 (80%) |
| 85 | 4 (80%) | 4 (80%) |
Across all 37 studies, recruiting or not: 35% stop at 75 or younger and 19% at 65; 14% take children; 3% are for women only and 3% for men only; 14% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 37 of 37. search them.
- Study of Diosmin for the Treatment of Digital Ulcers in Systemic SclerosisRecruitingNCT06256575Not applicable1 country
- A Study of Healthy Donor CD19-targeted Allogeneic CAR T Cells in Participants With Severe, Refractory Autoimmune DiseasesRecruitingNCT07115745Phase 110 countries
- Zero CDE Technique for Lens Removal During FLACSNot yet recruitingNCT07404293Not applicable1 country
- A Study to Evaluate Vimseltinib in Adults With Active Chronic Graft-Versus-Host Disease (cGVHD)RecruitingNCT06619561Phase 21 country
- Physiological Effects of N-Acetyl Cysteine in Patients With Multiple SclerosisEnrolling by invitationNCT03032601Not applicable1 country
- Relation Between Aortic Sclerosis &Severity of Coronary Heart Disease.Not yet recruitingNCT069652181 country
- Effects of Individualized Training to Reduce Fatigue in Patients With Newly and Advanced Diagnosed Multiple SclerosisRecruitingNCT06201026Not applicable1 country
- Magnetic Imaging for Diagnostic of Amyotrophic Lateral SclerosisRecruitingNCT04868994Not applicable1 country
- Finding Patterns In Clinical Study Experiences of Multiple Sclerosis PatientsNot yet recruitingNCT05503524
- Secondary Sclerosis Cholangitis ProspectiveActive, not recruitingNCT035667971 country
- Aerobic Exercise for Remyelination in Multiple SclerosisCompletedNCT04539002Not applicable1 country
- Pulmonary Artery Remodelling With BosentanCompletedNCT00595049Phase 41 country
- Acceptability of Exoskeleton Assisted Walking for Persons With Mobility Issues Due to Multiple SclerosisCompletedNCT04786821Not applicable1 country
- A Study of RD06-04 in Patients With Active Autoimmune DiseasesWithdrawnNCT06548620Early Phase 11 country
- A Study of CNTY-101 in Participants With Refractory B Cell-mediated Autoimmune DiseasesActive, not recruitingNCT06255028Phase 11 country
- Individual Patient Expanded Access IND of Autologous HBadMSCs for the Treatment of Amyotrophic Lateral SclerosisNo longer availableNCT045149521 country
- "Individual Patient Expanded Access IND to Treat Primary Lateral Sclerosis"No longer availableNCT048256131 country
- Allogeneic Mesenchymal Stem Cell-Derived Exosome Therapy for Progressive Multiple SclerosisSuspendedNCT07146087Early Phase 11 country
- PET Study of PIPE-791 in Healthy Volunteers and Volunteers With PrMS and IPFCompletedNCT06683612Phase 11 country
- Metformin Add-on Clinical Study in Multiple Sclerosis to Evaluate Brain Remyelination And NeurodegenerationActive, not recruitingNCT05893225Phase 21 country
- Expanded Access Program for Tofersen in Participants With Superoxide Dismutase 1-Amyotropic Lateral SclerosisApproved for marketingNCT049724871 country
- Power Training in Older Multiple Sclerosis PatientsStatus unknownNCT04762342Not applicable1 country
- Scleroderma: Cyclophosphamide or TransplantationCompletedNCT00114530Phase 2/32 countries
- Behavior and Activity Monitoring in MSCompletedNCT03244696Not applicable1 country
- Assessment of Language Disorders in Multiple Sclerosis PatientsCompletedNCT04465084Not applicable1 country
- Endovascular Versus Medical Treatment for the Pelvic Congestion SyndromeStatus unknownNCT04358497Phase 4
- Simtuzumab (GS-6624) in the Prevention of Progression of Liver Fibrosis in Adults With Primary Sclerosing Cholangitis (PSC)CompletedNCT01672853Phase 210 countries
- A Study of Participants With Relapsing-Remitting Multiple Sclerosis (RRMS)CompletedNCT00882999Phase 213 countries
- A Longitudinal Study of Amyotrophic Lateral Sclerosis (ALS) BiomarkersCompletedNCT014953901 country
- SCOT Scleroderma Treatment Alternative Registry (STAR Registry)CompletedNCT008605481 country
- Efficacy Study of Adrenocorticotropin Hormone to Treat Multiple Sclerosis (MS) Relapses After Sub-responding to an Initial 3 Day Course of Intravenous (IV) MethylprednisoloneTerminatedNCT00947895Phase 2/31 country
- A Retrospective Study to Understand the Clinical Management of Subjects With Multiple Sclerosis at a Site in Taiwan Over the Last 10 YearsCompletedNCT010847981 country
- A Non-Interventional Pilot Study Assessing Whether Lysyl Oxidase-like 2 (LOXL2) is Present in Subjects With SclerodermaCompletedNCT018815291 country
- An Observational Study to Assess the Quality of Life of the Patients With Multiple Sclerosis and Their CaregiversCompletedNCT010757371 country
- Levetiracetam for Cramps, Spasticity and Neuroprotection in Motor Neuron DiseaseCompletedNCT00324454Phase 21 country
- Premature Coronary Atherosclerosis in SclerodermaCompletedNCT003723981 country
- Molecular Imaging Modality by Positron Emission Tomography Using 18F-X : Study of Microglial Activation in Amyotrophic Lateral SclerosisStatus unknownNCT00563537Phase 11 country