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Not yet recruitingNCT07849816FTNF-SEPUpdated Sep 30, 2026

Assessment of the Frequency of Functional Neurological Disorders in Multiple Sclerosis and Analysis of Clinical and Psychological Determinants: A Multicenter Cross-Sectional Study

An observational study in Functional Neurological Disorders and Multiple Sclerosis, sponsored by University Hospital, Strasbourg, France. Not yet recruiting. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-30.

Sponsored by University Hospital, Strasbourg, France · Observational

Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
100
Ages
18 Years and older
Sex
All
01

Study summary

Multiple sclerosis (MS) and functional neurological disorders (FND) share clinical features, which may result in FND being overlooked in patients with MS. They also share common comorbidities, including depression and alexithymia.

As their management differs, assessing the frequency and determinants of FND in patients with MS is important to improve diagnosis and ensure appropriate management.

Read the detailed description

Multiple sclerosis (MS) and functional neurological disorders (FND) share clinical features, which may result in FND being overlooked in patients with MS. They also share common comorbidities, including depression and alexithymia.

As their management differs, assessing the frequency and determinants of FND in patients with MS is important to improve diagnosis and ensure appropriate management.

02

Conditions studied

  • Functional Neurological Disorders
  • Multiple Sclerosis

Keywords

  • Multiple Sclerosis
  • Functional Neurological Symptoms Disorder
  • Neurological Disability
  • Disease Activity
  • MS Relapse
  • Anxiety
  • Depression
  • Alexithymia
  • Quality of Life
  • Psychological Factors Comorbidities
03

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

During a routine medical visit, eligible patients will be informed about the study and invited to participate.

The two participating centers, located in Strasbourg and Nancy, each have an active cohort allowing the required number of participants to be recruited within one year.

Inclusion criteria

  • Adult patient (≥ 18 years of age)
  • Diagnosis of multiple sclerosis (MS) according to the 2024 McDonald criteria
  • Stable brain MRI performed within the previous 12 months
  • No relapse between the MRI and study enrollment
  • Ability to understand French
  • Affiliated with the French national health insurance system
  • Willing to participate in the study

Exclusion criteria

Exclusion Criteria:

  • Patient unwilling to participate in the study
  • Known severe psychotic disorder
  • Patient under judicial protection (sauvegarde de justice)
  • Patient under guardianship or curatorship (tutelle or curatelle)
04

Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
100 participants (estimated)
Patient registry
No
05

What researchers measure

Primary outcomes

  1. Assessment of the frequency of TNF in patients with multiple sclerosis

    Assessment of the frequency of TNF in patients with multiple sclerosis

    Time frame: day0

06

Study locations

No study locations are listed for this record.

07

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT07849816
Lead sponsor
University Hospital, Strasbourg, France
Responsible party
Sponsor
First posted
Sep 30, 2026
Start date
Oct 2, 2026 (estimated)
Primary completion
Oct 1, 2027 (estimated)
Completion
Oct 1, 2027 (estimated)
Last update
Sep 30, 2026

Study contacts

BEN HADJ HAMED Monia
Contact
monia.ben-hadj-hamed@chru-strasbourg.fr
003388116711
BIGAUT Kevin, Doctor
principal investigator · Hôpitaux Universitaires de Strasbourg

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.

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