Esophagitis clinical trials
The registry lists 123 studies for Esophagitis across more than 10 countries. 15 are recruiting or about to start. 54 of them are mainly about Esophagitis (how this is decided). Per ClinicalTrials.gov, last updated 2026-09-24. Counting its 2 narrower conditions too, such as Eosinophilic Esophagitis: 413 studies, 82 open.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
Takeda (11) · AstraZeneca (5) · Daewoong Pharmaceutical Co. LTD. (4) · HK inno.N Corporation (4) · Ellodi Pharmaceuticals, LP (4) · Pfizer (4) · University of Utah (3) · EndoGastric Solutions (3)
What is being tested here
Drugs under test in Esophagitis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Alginates | 1 | 0 | 1 |
| Alginic Acid | 1 | 0 | 1 |
| Dupilumab | 1 | 0 | 1 |
| APT-1011 | 0 | 3 | 4 |
| Domperidone | 0 | 1 | 3 |
| Omeprazole | 0 | 0 | 3 |
| Linaprazan glurate | 0 | 0 | 2 |
| Cendakimab | 0 | 2 | 2 |
| Lansoprazole | 0 | 0 | 2 |
| Mepolizumab | 0 | 0 | 2 |
Drug classes tested here Proton pump inhibitors (PPIs) 10 · Corticosteroids 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 3, phase 3 first
- Oct 2027Domperidone in Treating Patients With Gastrointestinal Disorders · Phase 3 · M.D. Anderson Cancer Center
- Dec 2026Prevention of Oral Mucositis and Improvement of Quality of Life for Patients With Breast Cancer Undergoing Adjuvant Radiotherapy · Taipei City Hospital
- Apr 2027Crural Repair During Laparoscopic Sleeve Gastrectomy in Patients With a Lax Gastroesophageal Junction · Sengkang General Hospital
Who these studies take
Of the 10 Esophagitis studies recruiting now, 6 (60%) set no upper age limit and 4 (40%) stop at 75 or younger. 2 (20%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (10%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (20%) | 2 (20%) |
| 18 | 7 (70%) | 7 (70%) |
| 30 | 9 (90%) | 9 (90%) |
| 40 | 9 (90%) | 9 (90%) |
| 50 | 9 (90%) | 9 (90%) |
| 65 | 8 (80%) | 8 (80%) |
| 75 | 6 (60%) | 6 (60%) |
| 85 | 6 (60%) | 6 (60%) |
Across all 123 studies, recruiting or not: 43% stop at 75 or younger and 21% at 65; 23% take children; 1% are for women only and 2% for men only; 11% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Esophagitis studies take
Of 18 phase 3 interventional studies under Esophagitis, half reached primary completion within 24 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 3 | 24 mo11–34 · 18 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 123. Browse all 123 → or search them.
- The Johns Hopkins Heartburn Center RegistryEnrolling by invitationNCT038537721 country
- Esomeprazole and Radiation Induced EsophagitisRecruitingNCT06120803Phase 21 country
- Efficacy and Safety of DWP14012 for Long-Term Maintenance Therapy in Patients With Healed Erosive EsophagitisNot yet recruitingNCT07746518Phase 3
- PULSO Trial: Pulsed Low-Dose-Rate (PLDR) Radiation Chemoradiation (CRT) vs. Standard CRT for Esophageal CancerRecruitingNCT06906887Phase 21 country
- Immunonutrition Reduces Acute Esophagitis After Thoracic Radiotherapy in Lung CancerRecruitingNCT06840704Phase 31 country
- Using Red Light Therapy to Ease Skin Side Effects and Mouth Side Effects, in Children and Young People Aged 0 to 16 Years Old, Receiving RadiotherapyNot yet recruitingNCT07183267Not applicable1 country
- Prevention of Oral Mucositis and Improvement of Quality of Life for Patients With Breast Cancer Undergoing Adjuvant RadiotherapyEnrolling by invitationNCT06958445Phase 21 country
- Raman Spectroscopy-Based Deep Learning Model for Early Pan-Cancer Early DiagnosisRecruitingNCT068224131 country
- Indonesian Study of Vonoprazan Vs Esomeprazole in Erosive EsophagitisNot yet recruitingNCT06720610Phase 41 country
- Effect of Dupilumab on the Muscle Function of the Esophagus (food Pipe) in Participants with Eosinophilic Esophagitis (EoE)RecruitingNCT06665971Phase 41 country
- Esophagus-sparing Radiotherapy for Metastatic Spinal Cord Compression.RecruitingNCT05109819Not applicable1 country
- Deep-sea Fish Oil for Prevention of Acute Radiation-induced EsophagitisRecruitingNCT06392971Phase 21 country
- The Effect of Physiotherapy on Post POEM RefluxRecruitingNCT05326113Not applicable1 country
- Crural Repair During Laparoscopic Sleeve Gastrectomy in Patients With a Lax Gastroesophageal JunctionRecruitingNCT05330910Not applicable1 country
- Management of Esophagitis Following Repair of Esophageal AtresiaRecruitingNCT036194081 country
- Domperidone in Treating Patients With Gastrointestinal DisordersActive, not recruitingNCT01696734Phase 31 country
- Reducing Acute Upper Gastrointestinal Side-Effects of Thoracic IrradiationCompletedNCT05659576Phase 21 country
- A Study in Patients With Erosive Esophagitis to Investigate Safety, Tolerability, and Healing Rates After 4 Weeks Treatment of X842 or Lansoprazole and Symptom Pattern During Subsequent 4 Weeks Treatment With LansoprazoleCompletedNCT05055128Phase 28 countries
- Risk Factors and Biomarkers for Diagnosis and Treatment of EoECompletedNCT019882851 country
- Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of X842 in Human: A Single/Multiple Ascending Dose StudyCompletedNCT03105375Early Phase 11 country
- A Study to Evaluate the Efficacy and Safety of BLI5100 in Patients With Erosive EsophagitisCompletedNCT05587309Phase 31 country
- Protonix Treatment of Maintenance of Healing in Pediatric Participants Aged 1-11 Years and 12-17 YearsTerminatedNCT04821310Phase 29 countries
- A Study of CDX-0159 in Patients With Eosinophilic EsophagitisCompletedNCT05774184Phase 28 countries
- A Study to Check the Safety of Dexlansoprazole and Learn If it Can Heal Erosive Esophagitis (EE) and Keep it Healed in Children 2 to 11 Years OldTerminatedNCT02615184Phase 25 countries
- Safety Study of CC-93538 in Adult and Adolescent Participants With Eosinophilic EsophagitisCompletedNCT04991935Phase 315 countries
- Bioequivalence Study to Compare Vonoprazan 20 mg Film Coated Tablets Versus Voquezna® 20 mg (Vonoprazan) TabletsCompletedNCT07278349Phase 11 country
- Expanded Access Protocol for Patients With Eosinophilic EsophagitisNo longer availableNCT050951161 country
- 24-Week Induction Study of APT-1011 in Adult Subjects With Eosinophilic Esophagitis (EoE) (FLUTE 3)CompletedNCT05634746Phase 32 countries
- A Study to Evaluate the Efficacy and Safety of CC-93538 in Adult and Adolescent Participants With Eosinophilic EsophagitisCompletedNCT04753697Phase 315 countries
- A Food Additive Removal Diet for Pediatric Eosinophilic EsophagitisCompletedNCT03657771Not applicable1 country
- A Multi-center, Randomized, Double-blind Phase III Clinical Trial to Assess and Compare to the Efficacy and Safety of Lafutidine, Famotidine and Omeprazole-referenced in Korean Erosive Esophagitis PatientsCompletedNCT01499368Phase 3
- JP-1366 20mg Versus Esomeprazole 40mg in Patients With Erosive EsophagitisCompletedNCT05443984Phase 31 country
- Proton Pump Inhibitor (PPI) Response in Eosinophilic Esophagitis Assessed by Transnasal Endoscopy (TNE)Active, not recruitingNCT04149470Phase 41 country
- The Bacterial Composition of the Stomach in Reflux DiseaseActive, not recruitingNCT038356631 country
- A Study of Lirentelimab (AK002) in Patients With Active Eosinophilic EsophagitisCompletedNCT04322708Phase 2/33 countries
- A Study to Evaluate the Safety, Tolerability and Pharmacokinetics/Pharmacodynamics of Oral Doses of H008CompletedNCT05050188Phase 11 country
- Vonoprazan Study in Patients With Erosive Esophagitis to Evaluate Long-term SafetyCompletedNCT02679508Phase 41 country
- Study to Identify Non-Invasive Markers of Gastrointestinal AllergyCompletedNCT002728181 country
- Efficacy and Safety APT-1011 in Adolescent Subjects With Eosinophilic Esophagitis (EoE) - A Sub-Study of the FLUTE-2 TrialCompletedNCT05083312Phase 32 countries
- Mesalazine Oral Suspension in Active Eosinophilic EsophagitisCompletedNCT05488405Phase 21 country
- Efficacy and Safety APT-1011 in Adult Subjects With Eosinophilic Esophagitis (EoE) (FLUTE-2)CompletedNCT04281108Phase 33 countries
- Clinical Investigation to Assess the Acid Neutralisation Activity of a Calcite Chewing GumCompletedNCT05129670Not applicable1 country
- Efficacy, Safety, and Pharmacokinetics of APT-1011 in Subjects With Eosinophilic Esophagitis (EoE)CompletedNCT03191864Phase 26 countries
- Effects of Intravenous GC4419 on the Incidence and Severity of Esophagitis Due to Chemoradiotherapy for Lung CancerTerminatedNCT04225026Phase 21 country
- Study to Confirm the Safety and Efficacy of Tegoprazan in Patients With Healed Erosive EsophagitisCompletedNCT04022096Phase 31 country
- A Study of Anaprazole Sodium Enteric-coated Tablets in the Treatment of Reflux EsophagitisStatus unknownNCT05604261Phase 21 country
- Efficacy and Safety of Vonoprazan Compared to Lansoprazole in Participants With Erosive EsophagitisCompletedNCT04124926Phase 36 countries
- Randomized Trial of Glutamine in Patients With Mucositis or EsophagitisTerminatedNCT01952847Phase 31 country
- Twenty Four Hour Ambulatory pH & Impedance Testing: Normative Data for Indian PopulationStatus unknownNCT050041551 country
- Study of Dietary Patterns and Food Diversity in Russian GERD PatientsStatus unknownNCT04252144Not applicable1 country