Barrett Esophagus clinical trials

The registry lists 312 studies for Barrett Esophagus across more than 10 countries. 60 are recruiting or about to start. 264 of them are mainly about Barrett Esophagus (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.

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Status

Completed: 160
Recruiting: 44
Status unknown: 39
Terminated: 31
Active, not recruiting: 14
Enrolling by invitation: 8

Phase

Phase 2: 18
Phase 1: 16
Phase 4: 12
Early Phase 1: 10
Phase 3: 6

Where

United States: 209
Netherlands: 28
United Kingdom: 24
France: 14
Germany: 13
Belgium: 9

Who runs them

Mayo Clinic (40) · Massachusetts General Hospital (17) · University of North Carolina, Chapel Hill (10) · Midwest Biomedical Research Foundation (10) · National Cancer Institute (NCI) (8) · Johns Hopkins University (7) · Columbia University (7) · University of Colorado, Denver (6)

What is being tested here

Drugs under test in Barrett Esophagus studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

Drug	Open	Phase 3	All
Bevacizumab-IRDye 800CW	1	0	2
Itraconazole	1	0	1
Obeticholic acid	1	0	1
Bevacizumab	1	0	1
Esomeprazole	0	1	6
Proflavine	0	0	3
Aspirin	0	0	2
YF 476	0	0	2
Omeprazole	0	0	2
Dexlansoprazole	0	0	2

Drug classes tested here Proton pump inhibitors (PPIs) 12

Coming up

0phase 3 studies under way

17studies finish main data collection within a year

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest

Nov 2026Barrett's Esophagitis in Anorexia Nervosa Binge/Purge Subtype · Denver Health and Hospital Authority
Nov 2026Barrett's Esophagus Related Neoplasia (BERN) Project · Midwest Biomedical Research Foundation
Dec 2026Cell Marker Predictors in Barrett's Esophagus · The Guthrie Clinic
Dec 2026Digma System First in Human (FIH) Study · Digma Medical Ltd.
Jan 2027TREAT-BE Study (Treatment with Resection and Endoscopic Ablation Techniques for Barrett's Esophagus) · University of Colorado, Denver
Feb 2027Endoscopic Submucosal Dissection (ESD) · AdventHealth
May 2027A Multicenter Prospective Cohort Study Comparing Random Biopsies Versus Wide-Area Transepithelial Brush-Sampling (WATS) for Surveillance of Barrett's Esophagus, the WATS-EURO2 Study · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Jun 2027Biomarkers of Airway Disease, Barrett's and Underdiagnosed Reflux Noninvasively (BADBURN) · NYU Langone Health
Jun 2027Efficacy of EsoGuard Assay on Esophageal Surface Cells Collected With EsoCheck vs EGD for the Diagnosis of BE or EAC · Lucid Diagnostics, Inc.
Jun 2027Assessment of a Minimally Invasive Collection Device for Molecular Analysis of Esophageal Samples · Mayo Clinic

Who these studies take

Of the 44 Barrett Esophagus studies recruiting now, 31 (70%) set no upper age limit and 2 (5%) stop at 75 or younger. 4 (9%) take children under 18. 1 (2%) are for women only and 0 (0%) for men only; 10 (23%) take healthy volunteers.

Recruiting studies that take each age, of 44
Age	Women	Men
10	3 (7%)	3 (7%)
18	40 (91%)	39 (89%)
30	42 (95%)	41 (93%)
40	43 (98%)	42 (95%)
50	44 (100%)	43 (98%)
65	44 (100%)	43 (98%)
75	42 (95%)	41 (93%)
85	42 (95%)	41 (93%)

Across all 312 studies, recruiting or not: 8% stop at 75 or younger and 2% at 65; 6% take children; <1% are for women only and 1% for men only; 19% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Barrett Esophagus studies take

Of 76 interventional studies with no phase under Barrett Esophagus, half reached primary completion within 45 months of starting, counting those still running.

Start to primary completion	Every sponsor	Industry	Non-industry
Interventional, no phase	45 mo23–108 · 76 studies	—	52 mo24–108 · 65 studies
Observational	252 mo37–252 · 40 studies	—	—

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 13, 2026.

Started recruiting1

Efficacy of Potassium-Competitive Acid Blockers in Barrett's Esophagus (PCAB BE Study)Nov 5, 2026NCT07788742

Newly registered1

Lucid BE Biomarkers StudyOct 21, 2026NCT07887568

Studies

Recruiting first, then most recently updated. Showing 50 of 312. Browse all 312 → or search them.