An observational study in Lung; Disease, Interstitial, With Fibrosis, Alveolitis, Extrinsic Allergic and Bird Fancier's Lung, sponsored by University of Dundee. Completed at 2 sites in United Kingdom. Open to participants aged 18 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-05-27.
Sponsored by University of Dundee · Observational
The investigators aim to examine the genetic determinants of interstitial lung disease in a cohort of subjects with regular exposure to pigeons, a known cause of one form of interstitial lung disease known as hypersensitivity pneumonitis. In addition we will examine immunological causes for hypersensitivity pneumonitis in this group.
We anticipate our work will provide insights of use to clinicians and patients with hypersensitivity pneumonitis and other interstitial lung diseases.
The investigators aim to recruit participants with regular racing pigeon exposure at national (UK) and regional pigeon fancier meetings.
Consenting subjects will complete questionnaires, provide blood samples for genetic analysis and immunological testing and undertake lung function measurements.
Subjects will be observed, and encouraged to report referral to specialist respiratory services, and following this information will be sought on diagnosis (including supporting evidence). Where interstitial lung disease is detected this will be linked to subsequent unbiased analysis to detect potential predisposing genetic associations.
34 studies on the registry are indexed under Alveolitis, Extrinsic Allergic; 11 are open to participants now.
This study's enrollment of 475 is above the median of 147 across 16 observational studies indexed under Alveolitis, Extrinsic Allergic.
Browse Alveolitis, Extrinsic Allergic studies →University of Dundee is the lead sponsor of 113 studies on the registry; 3 are open to participants now.
Of its 5 completed or terminated interventional studies of FDA-regulated products, 3 (60%) have results posted.
Compared within Alveolitis, Extrinsic Allergic, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Disease. The counts are of registry records indexed under each term, refreshed daily. How we classify →
Participants in the sport of Pigeon racing
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Exclusion Criteria:
All participating subjects will undergo detailed genetic analysis, with the aim of detecting novel genetic drivers for the development of interstitial lung disease in the context of known sensitising agent (pigeon antigen)
Relationship of specific genetic markers to development of interstitial lung disease
Participants will be screened for MUC5B genetic profile to allow examination of MUC5B genetic profile relationship with risk of developing interstitial lung disease in this group
Time frame: 5 years
Plan to share: Undecided — Will be considered, dependent on potential for increased power
No publications or documents are linked to this record.
Ran from Jan 2019 to primary completion in Jan 2025, 72 months.
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This study is completed, as verified in May 2026. You cannot join it, but the record below documents what was studied.
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Alveolitis, Extrinsic Allergic →