An observational study in Long QT Syndrome, ADHD and Depression, sponsored by Copenhagen University Hospital at Herlev. Status unknown at 1 site in Denmark. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2019-01-03.
Sponsored by Copenhagen University Hospital at Herlev · Observational
Studies have shown that the risk of developing heart arrhythmias, is increased in patients receiving medication for Attention-deficit hyperactivity disorder (ADHD) and depression. The QT-interval on a electrocardiogram (ECG) is often used to assess the patients risk of developing heart arrhythmias. The QT-interval defines the hearts electrical resting period and a long interval is linked to an increased risk of developing heart arrhythmias. In this project the investigators wish to examine possible side-effects in patients receiving medication for ADHD and depression and their dynamic QT-interval changes, by analysing the ECG changes that occur during "Brisk Standing".
50 Patients treated with Methylphenidate 50 Patients treated with Methylphenidate and QT-prolonging SSRI 50 Patients treated with Methylphenidate and a non QT-prolonging SSRI
Exclusion Criteria:
The group is examined before and after intake of Methylphenidate
Diagnostic Test: Electrocardiogram examination · Diagnostic Test: Echocardiography · Procedure: Blood Samples · Behavioral: Questionnaire
The group is examined before and after intake of Methylphenidate
Diagnostic Test: Electrocardiogram examination · Diagnostic Test: Echocardiography · Procedure: Blood Samples · Behavioral: Questionnaire
The group is examined before and after intake of Methylphenidate
Diagnostic Test: Electrocardiogram examination · Diagnostic Test: Echocardiography · Procedure: Blood Samples · Behavioral: Questionnaire
12-lead ECG monitored by Holter
Echocardiography in accordance to Danish Society of Cardiology
Blood Samples include, Genetic analysis, serum-Methylphenidate, serum-Citalopram. Sodium, Potassium, Magnesium, Calcium, Chloride, White-Blood-Count, Hemoglobin, C-reactive-Protein, Creatinine, Carbamide, aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT), Glucose and pro-brain natriuretic peptide (Pro-BNP).
Questionnaire regarding patients quality of life
ECG changes
The Primary Outcome assess whether there are changes on ECG, primary the QTc-interval, in participants receiving medication for ADHD and depression.
Time frame: Through study completion, an average of 1 year.
This study is status unknown, as verified in Jan 2019. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Copenhagen University Hospital at Herlev