An observational study in Aortic Stenosis, sponsored by Institut für Pharmakologie und Präventive Medizin. Completed at 2 sites in United Kingdom. Open to participants aged 65 Years and older. Per ClinicalTrials.gov, last updated 2020-02-12.
Sponsored by Institut für Pharmakologie und Präventive Medizin · Observational
Prospective cohort study to test the hypothesis that patients identified with severe aortic stenosis are under-diagnosed and under-treated. Such patients shall be identified by auscultation or target echocardiography during flu vaccination. The hypothesis is that this will increase detection of aortic stenosis in the community.
The design plans for two study phases:
In each phase, the patient will be identified by auscultation and target echocardiography. Management and onward referral will be at the clinical discretion of the GP. Results of clinical review, investigation, follow-up and management will be recorded at 3 months from that date.
Patients identified on auscultation or target echocardiography with aortic stenosis. Consecutive patients per centre with no limit to numbers.
Exclusion Criteria:
Patients identified on auscultation or target echocardiography with aortic stenosis. Consecutive patients per centre with no limit to numbers.
prevalence of aortic stenosis
Determination of the prevalence of aortic stenosis detected on screening performed during flu vaccination.
Time frame: From date of examination until follow-up after three months
comparison of detection rate of aortic stenosis
Comparison of detection rates of aortic stenosis using target auscultation vs detection by target 2D echocardiography.
Time frame: From date of examination until follow-up after three months
Evaluation of qualitative estimation of calcium burden on 2D echocardiography as a marker of AS severity
Method evaluation
Time frame: three months
Calculation of costs in screening with auscultation versus target 2DE in screening for AS to inform future cost-efficacy studies of screening for AS.
Cost evaluation
Time frame: three months
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Feb 2020. You cannot join it, but the record below documents what was studied.
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Institut für Pharmakologie und Präventive Medizin