An observational study in Respiratory Distress Syndrome, Adult and Ventilator-Induced Lung Injury, sponsored by Centro de Educación Medica e Investigaciones Clínicas Norberto Quirno. Completed at 5 sites in Argentina. Open to participants aged 18 Years to 100 Years. Per ClinicalTrials.gov, last updated 2020-01-06.
Sponsored by Centro de Educación Medica e Investigaciones Clínicas Norberto Quirno · Observational
Asynchrony during mechanical ventilation has been poorly described in patients suffering from acute respiratory distress syndrome. The purpose of this study is to describe the frequency of asynchronies (ineffective efforts and double triggering) in these group and evaluate potential risk factors and prognosis implications.
Major patient-ventilator asynchronies have been described during assisted mechanical ventilation in different settings. Few studies have evaluated double cycling in ARDS patient. No clear predictors of this finding beside low tidal volume have been found, and clinical outcome implications have not been addressed. This study has 3 main objectives: evaluate the frequency of double cycling and ineffective efforts, seek for potential predictors and clinical outcomes related to asynchronies. Subjects with less than 72 hours of mechanical ventilation due to ARDS will be recruited. Thirty minutes of mechanical ventilation will be recorded and automatically analyzed with a custom-made program to detect asynchronies. A blood sample will be drawn to measure inflammatory and lung tissue damage biomarkers. Clinical and outcome data will be recorded.
1,597 studies on the registry are indexed under Respiratory Distress Syndrome; 312 are open to participants now.
This study's enrollment of 103 is close to the median of 100 across 540 observational studies indexed under Respiratory Distress Syndrome.
Browse Respiratory Distress Syndrome studies →Centro de Educación Medica e Investigaciones Clínicas Norberto Quirno is the lead sponsor of 6 studies on the registry; none are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients with diagnosis of acute respiratory distress syndrome and mechanical ventilation for less than 72 hours
Exclusion Criteria:
Asynchrony rate
Asynchronies per minutes of mechanical ventilation
Time frame: 30 minutes
Length of mechanical ventilation
Time frame: From the date of intubation to the date of complete weaning from mechanical ventilation or death which ever comes first, up to 90 days
ICU mortality
Time frame: From the date of admission to the date of discharge from the ICU, up to 90 days
Hospital mortality
Time frame: From the date of admission to the date of discharge from the ICU, up to 90 days
Plan to share: No
This study is completed, as verified in Jan 2020. You cannot join it, but the record below documents what was studied.
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Respiratory Distress Syndrome→
Centro de Educación Medica e Investigaciones Clínicas Norberto Quirno