Mastocytosis clinical trials
The registry lists 49 studies for Mastocytosis across more than 10 countries. 14 are recruiting or about to start. 22 of them are mainly about Mastocytosis (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12. Counting its 2 narrower conditions too, such as Leukemia, Mast-Cell: 132 studies, 26 open.
Get an email when these change. Save the Mastocytosis studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Who runs them
National Institute of Allergy and Infectious Diseases (NIAID) (8) · University Hospital, Toulouse (4) · Blueprint Medicines Corporation (4) · AB Science (4) · M.D. Anderson Cancer Center (2) · Hospital Virgen de la Salud (2) · University of Zurich (2) · Cogent Biosciences, Inc. (2)
What is being tested here
Drugs under test in Mastocytosis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Masitinib | 1 | 2 | 4 |
| Bezuclastinib | 1 | 0 | 2 |
| Imatinib | 0 | 0 | 3 |
| Fludarabine | 0 | 0 | 1 |
| Busulfan | 0 | 0 | 1 |
| Cyclophosphamide | 0 | 0 | 1 |
| Tacrolimus | 0 | 0 | 1 |
| Mycophenolic Acid | 0 | 0 | 1 |
| Dasatinib | 0 | 0 | 1 |
| 2019-nCoV Vaccine mRNA-1273 | 0 | 0 | 1 |
Drug classes tested here Tyrosine kinase inhibitors (TKIs) 2 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 2
- Jul 2027Angioedema Biomarker Research Study · Foundation For Rare Disease Research
- Oct 2027Myeloproliferative Neoplasms (MPNs) Patient Registry · University Health Network, Toronto
Who these studies take
Of the 14 Mastocytosis studies recruiting now, 11 (79%) set no upper age limit and 2 (14%) stop at 75 or younger. 6 (43%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 4 (29%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 5 (36%) | 5 (36%) |
| 18 | 14 (100%) | 14 (100%) |
| 30 | 14 (100%) | 14 (100%) |
| 40 | 14 (100%) | 14 (100%) |
| 50 | 14 (100%) | 14 (100%) |
| 65 | 14 (100%) | 14 (100%) |
| 75 | 14 (100%) | 14 (100%) |
| 85 | 11 (79%) | 11 (79%) |
Across all 49 studies, recruiting or not: 31% stop at 75 or younger and 12% at 65; 45% take children; 2% are for women only and 0% for men only; 14% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 49 of 49. search them.
- Study of Factors Regulating Mast Cell ProliferationRecruitingNCT000441221 country
- A Non-Interventional Study in Participants With Indolent Systemic Mastocytosis (ISM) in GermanyRecruitingNCT072556381 country
- Screening Study for KIT D816V Mutated Mast Cell Disease in Select PopulationsRecruitingNCT071436692 countries
- (Apex) Bezuclastinib in Patients With Advanced Systemic MastocytosisRecruitingNCT04996875Phase 214 countries
- An Observational Study in Participants With Indolent Systemic Mastocytosis (ISM)RecruitingNCT072649591 country
- Angioedema Biomarker Research StudyRecruitingNCT062106981 country
- Epidemiological Data on Mast Cell Pathologies in FranceRecruitingNCT061868561 country
- Institutional Registry of Rare DiseasesRecruitingNCT065737231 country
- Analysis of the Role of IgE Proteoforms in Health and DiseaseRecruitingNCT073281781 country
- Myeloproliferative Neoplasms (MPNs) Patient RegistryRecruitingNCT027602381 country
- Mastocytosis Registry (of Zurich)RecruitingNCT064668891 country
- Relationship Between Circulating Sclerostin and Bone Lesions in Patients With MastocytosisRecruitingNCT064401481 country
- Evaluation of the DALY on a Cohort of Patients With Indolent Systemic MastocytosisRecruitingNCT059233721 country
- Masitinib in Severe Indolent or Smoldering Systemic Mastocytosis Unresponsive to Optimal Symptomatic TreatmentRecruitingNCT04333108Phase 38 countries
- (Summit) A Study to Evaluate the Efficacy and Safety of CGT9486 Versus Placebo in Patients With Indolent or Smoldering Systemic MastocytosisActive, not recruitingNCT05186753Phase 215 countries
- A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological MalignanciesCompletedNCT01384513Phase 21 country
- Pregnancy and Medically Assisted Conception in Rare DiseasesWithdrawnNCT024503961 country
- Dasatinib as Therapy for Myeloproliferative Disorders (MPDs)CompletedNCT00255346Phase 21 country
- Serum Basal Tryptase Levels in Healthy ChildrenCompletedNCT053231881 country
- COVID19 SARS Vaccinations: Systemic Allergic Reactions to SARS-CoV-2 VaccinationsCompletedNCT04761822Phase 21 country
- Cromoglicate in MastocytosisTerminatedNCT01701843Phase 21 country
- Study of Cellular Heterogeneity in Patients With MastocytosisStatus unknownNCT06432556Not applicable1 country
- Study of Mast Cell PrecursorsCompletedNCT000017561 country
- Therapy of HES, PV, Atypical Chronic Myelocytic Leukemia (CML) or Chronic Myelomonocytic Leukemia (CMML), and Mastocytosis With Imatinib MesylateCompletedNCT00038675Not applicable1 country
- Hydroxychloroquine in Isolated Cutaneous Mastocytosis Patients or Indolent Systemic Mastocytosis With Associated Skin Involvement PatientsStatus unknownNCT05084872Phase 2/31 country
- Mast Cell Connect: A Registry for Patients With MastocytosisCompletedNCT026202541 country
- Assessment of Burden Disease in Patients With Mast Cell DisordersStatus unknownNCT046156631 country
- Mast Cell Activation Test in Allergic DiseaseCompletedNCT034063251 country
- Cause and Natural Course of Pediatric-Onset MastocytosisCompletedNCT000501931 country
- Masitinib in Severe Indolent or Smoldering Systemic MastocytosisCompletedNCT00814073Phase 32 countries
- Evaluation and Long-Term Follow-Up of Patients With Allergic and Inflammatory DisordersTerminatedNCT005578951 country
- The Significance of Blood-tryptase and c-Kit Mutation in Insect Venom ImmunotherapyCompletedNCT025038001 country
- A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AK002CompletedNCT02808793Phase 11 country
- Efficacy of AB1010 in Patients With Systemic Indolent MastocytosisCompletedNCT00831974Phase 2
- Masitinib in Patients With Mastocytosis With Handicap and Bearing the D816V MutationCompletedNCT01266369Phase 2
- Mechanisms of Action of Photo(Chemo)Therapy in Skin DiseasesStatus unknownNCT03340155Not applicable1 country
- Stem Cell Transplantation to Treat Systemic MastocytosisCompletedNCT00006413Phase 21 country
- Phase II Study of Imatinib Mesylate in Patients With Life Threatening Malignant Rare DiseasesCompletedNCT00154388Phase 2
- Molecular Mechanisms and Diagnosis of MastocytosisCompletedNCT003360761 country
- Study on Mastocytosis for Rupatadine TreatmentCompletedNCT01481909Phase 2/31 country
- Treatment of Indolent Systemic Mastocytosis With PA101CompletedNCT02478957Phase 25 countries
- Imatinib in KIT-negative Systemic MastocytosisCompletedNCT01297777Phase 41 country
- Cladribine Plus Pegylated Interpheron Alfa-2a in Systemic MastocytosisStatus unknownNCT01602939Phase 2/31 country
- The Effect of Xolair ® (Omalizumab) in Mastocytosis PatientsCompletedNCT01333293Phase 2/31 country
- Midostaurin in Indolent Systemic MastocytosisStatus unknownNCT01920204Phase 21 country
- Natural History of Urticaria Pigmentosa in ChildrenCompletedNCT004677921 country
- Characteristics of Mast Cells in MastocytosisCompletedNCT000013561 country
- Blood Factors in Mastocytosis and Unexplained Anaphylaxis and FlushingCompletedNCT000479181 country
- Cytokine Production Patterns in Patients With Systemic Mastocytosis Compared With Atopic Dermatitis and Healthy IndividualsCompletedNCT000017601 country