To Compare Anti-VEGF Monotherapy With Anti-VEGF and EPM Grid Laser Combination Therapy for Diabetic Macular Edema

• Age ≥ 18 years with CSME
• Diagnosis of diabetes mellitus (type 1 or type 2)
• At least one eye meets the study eye criteria
• Able and willing to provide informed consent prior to any study-related procedures
• Central foveal thickness ≥ 300 microns at baseline (SPECTRALIS or Cirrus HD OCT)
• LogMAR Best corrected visual acuity 0.20 (Snellen 20/30) to 1.3 (Snellen 20/400).
• Willing and able to comply with clinic visits and study-related procedures
• Central Foveal Thickness on OCT 300-600 micron
• After first injection, wait for ME to reduce before proceeding with the laser. Exclude if ME persists >500um at the 4-week follow up

Exclusion Criteria:

• Macular edema is considered to be due to a cause other than diabetic macular edema.
• An ocular condition is present such that, in the opinion of the investigator, visual acuity loss would not improve from resolution of macular edema (e.g., foveal atrophy, VMT, pigment epithelium abnormalities, dense subfoveal hard exudates, non-retinal condition such as glaucoma etc).
• Substantial cataract that, in the opinion of the investigator, is likely to be affecting visual acuity. Likely to be affecting BCVA and performing laser treatment.
• History of treatment for diabetic macular edema at any time in the past (such as grid macular photocoagulation).
• History of treatment for diabetic macular edema at any time in the past 3 months (such as intravitreal or peribulbar corticosteroids, ranibizumab, bevacizumab, aflibercept).
• Focal laser photocoagulation should be performed before enrolling into the study if needed. 3 months gap required between last laser procedure and recruitment.
• History of panretinal (scatter) photocoagulation (PRP) within 3 months prior to enrollment.
• Anticipated need for PRP in the study period.
• History of major retinal surgery (including vitrectomy, scleral buckle, any glaucoma surgery, etc.).
• History of YAG capsulotomy performed within 3 months.
• Aphakia.
• Intraocular pressure ≥ 25 mmHg.
• History of open-angle glaucoma (either primary open-angle glaucoma or other cause of open-angle glaucoma; note: history of angle-closure glaucoma is not an exclusion criterion).
• Exam evidence of external ocular infection, including conjunctivitis, chalazion, or significant Blepharitis.
• Systemic Exclusion Criteria: A subject is not eligible if any of the following exclusion criteria are present:
• Significant renal disease, defined as a history of chronic renal failure requiring dialysis or kidney transplant.
• A condition that, in the opinion of the investigator, would preclude participation in the study (e.g., unstable medical status including blood pressure, cardiovascular disease, and glycemic control).
• Blood pressure > 180/110 (systolic above 180 OR diastolic above 110).
• Major surgery within 28 days prior to randomization or major surgery planned during the next 6 months.
• Myocardial infarction, other cardiac event requiring hospitalization, stroke, transient ischemic attack, or treatment for acute congestive heart failure within 6 months prior to randomization.
• Systemic anti-vascular growth factor (ranibizumab) or pro-VEGF treatment within 4 months.
• For women of childbearing potential: pregnant or lactating or intending to become pregnant within the next 12 months.
• Subject is expecting to move out of the area of the clinical center to an area not covered by another clinical center during the study.
• The target eye is the only eye of the subject, with the fellow eye's visual acuity lower than 1.3 LogMAR units.
• Baseline logMAR BCVA from 0.05 to 0.5 (Snellen)
• Fellow eye BCVA 0.05 or worse.