An observational study in Age-Related (Dry) Macular Degeneration, Age-Related Macular Degeneration (AMD) and AMD Population - Intermediate or Advanced AMD, sponsored by IRCCS San Raffaele. Not yet recruiting. Open to participants aged 50 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-29.
Sponsored by IRCCS San Raffaele · Observational
Age-related macular degeneration (AMD) is the major cause of legal blindness in developed countries. Intermediate AMD represents the most frequent stage. However, it often evolves towards complicated stages, namely neovascular AMD or geographic atrophy (GA). Despite the available treatments, the visual outcome is highly heterogeneous. The scientific interest is growing regarding the assessment of neuroretinal changes in AMD. Although AMD is mainly considered an outer retinal disease, recent evidence suggests a major involvement of retinal glia and neurons, i.e. an involvement of the inner retina. This damage may remarkably affect the morphological and functional AMD outcome, subverting retinal signal transmission cascade and more clearly explaining the outcome of the disease. The main goal of this study is to perform a multidisciplinary, multicenter, both prospective and retrospective evaluation of neuroretinal degeneration in different AMD stages in preclinical and clinical models.
Patients affected by intermediate, wet and dry (geographic atrophy) age-related macular degeneration (AMD) and healthy age- and gender-matched controls
Exclusion Criteria:
Patients affected by intermediate, wet and dry atrophic AMD
Healthy age- and gender-matched control
Neuroretinal degeneration quantitative metrics
Quantitative multimodal retinal imaging metrics associated with inner retinal changes and neuroretinal degeneration
Time frame: From January 2027 to January 2030
Imaging metrics of neuroretinal changes
Multimodal retinal imaging metrics associated with inner retinal changes and neuroretinal degeneration
Time frame: From January 2027 to January 2030
MicroRNA profiles associated with AMD stages
MicroRNAs different profiles associated with AMD stages, risk of progression and neuroretinal degeneration.
Time frame: From January 2027 to January 2030
No study locations are listed for this record.
Plan to share: Yes — Scientific publications and international conferences.
This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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IRCCS San Raffaele