An observational study in Hypothyroidism, Subclinical Hypothyroidism and Hyperthyroidism, sponsored by International Islamic University Malaysia. Completed. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-10-18.
Sponsored by International Islamic University Malaysia · Observational
This will be a population based study looking at the prevalence of thyroid disorders in Malaysia (including hypo- and hyperthyroidism, subclinical hypo- or hyperthyroidism) and its association with different ethnicity and iodine status. The study will also look at genetic susceptibility for autoimmune thyroid disorders in the Malaysian population
General hypotheses:
The prevalence of thyroid disorders in Malaysia is 10% for hypothyroidism and 2% for hyperthyroidism Hypo- and hyperthyroidism is associated with iodine status in our population There are different susceptibility gene for autoimmune thyroid disorder in different ethnicity in our population
This will be a cross-sectional population based study involving Malaysian adults (aged 18 year old and above). Cluster sampling will be used to select respondents that will be representative of the Malaysian population. Selected respondent will be interviewed, anthropometric measurement taken, blood and urine sample taken.
Blood will be analyzed for thyroid function (thyroxine, triiodothyronine and thyroid stimulating hormone), autoantibodies (anti-thyroperoxidase and anti-thyroglobulin). Urine will be analyzed for urinary iodine.
Those diagnosed with autoimmune thyroid disorders with strong family history of thyroid disorders (multiplex multi-generation family involvement) will have their blood sent for whole exome sequencing and linkage analysis done to identify possible susceptible gene for autoimmune thyroid disorders
Respondents detected to have hypo- or hyper- and subclinical hypo- or hyperthyroidism will be referred to their nearest health centre for further evaluation and treatment appropriate for their condition.
217 studies on the registry are indexed under Hypothyroidism; 50 are open to participants now.
This study's enrollment of 2,498 is above the median of 148 across 98 observational studies indexed under Hypothyroidism.
Browse Hypothyroidism studies →International Islamic University Malaysia is the lead sponsor of 16 studies on the registry; 4 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Adult (aged equal or more than 18 years old ) Malaysian citizen living in Malaysia at the time of sampling
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Number of participants with abnormal thyroid function
Overt or subclinical hypothyroidism Overt or subclinical hyperthyroidism
Time frame: Day 0
Number of participants with positive thyroid autoantibodies
Anti-thyroglobulin Anti-thyroperoxidase
Time frame: Day 0
Number of participants with Iodine deficiency status
Urinary iodine level
Time frame: Day 0
Number of participants with genetic susceptibility to autoimmune thyroid disorders
whole exome sequencing and linkage analysis in families with autoimmune thyroid disorders (multiplex multi-generation involvement)
Time frame: Day 0
No study locations are listed for this record.
This study is completed, as verified in Oct 2016. You cannot join it, but the record below documents what was studied.
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International Islamic University Malaysia