An interventional study of Enteral nutrition and Parenteral nutrition in Acute Respiratory Failure and Shock, sponsored by Centre Hospitalier Departemental Vendee. Completed at 41 sites in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-04.
Sponsored by Centre Hospitalier Departemental Vendee · Not applicable, Interventional, and Prevention
Among 107 studies in Shock with a site in France — 24 open to participants now, 27 under way, 1 of them phase 3. Shock · France.
Among the 107 studies in Shock with a site in France, this one is the 3rd largest by enrollment of the 46 interventional ones that give a count, is one of 3 that started in 2013, is one of 32 with no phase, and was the 18th registered.
487 studies on the registry are indexed under Shock; 107 are open to participants now.
Browse Shock studies →24 of the 107 studies in Shock with a site in France are open now. Recruiting first, the newest first:
CHU de Reims · Sites in France
Ages 18+
Centre Hospitalier Universitaire Dijon · Sites in France
Ages 18+
Bicetre Hospital · Sites in France
Ages 18+
University Hospital, Montpellier · Sites in France
Ages 0 days–3 mo
University Hospital, Bordeaux · Sites in France
Ages 0 days–15 yrs
A study can be open while its sites in France have not opened yet or have stopped. Only those recruiting at a site in France →
Of the 68 Shock studies recruiting now, 52 (76%) set no upper age limit and 11 (16%) stop at 75 or younger; 9 take children under 18; 4 take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
107 studies; the count open now beside each. This study's row is marked.
First in 2003; this study’s year is marked. 3 started in 2013.
By drug class, each counting the studies that test any of its medicines:
This study's enrollment of 2,410 is above the median of 100 across 229 interventional studies indexed under Shock.
Median enrollment 139 across the 46 interventional studies, 100 across the 61 observational. Of the 66 that completed or were terminated, 2 (3%) have results posted.
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4 of 107 have an industry lead sponsor. The 10 most frequent:
Centre Hospitalier Departemental Vendee is the lead sponsor of 83 studies on the registry; 12 are open to participants now.
Centre Hospitalier Departemental Vendee has 3 studies filed under Shock — fewer than ten, so there is no comparison to draw.
11 of the studies in Shock with a site in France that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07724262Bicetre HospitalEvaluation of the Argos System to Estimate Cardiac Output | 2026-12-31 |
| NCT05655065University Hospital, AngersEffects of Increasing Mean Arterial Pressure on Renal Function in Patients With Shock and With Elevated Central Venous Pressure | 2026-12-31 |
| NCT07255469University Hospital, BordeauxMetabolic Fluid Responsiveness in Children | 2027-03-21 |
| NCT07203833Centre Hospitalier Universitaire, AmiensDiagnostic and Prognostic Evaluation of Vasorin During Septic Shock | 2027-04 |
| NCT06839404Bicetre HospitalPharmacodynamic Analysis of the HaemOdynamic Effects of a Standard Fluid BolUS | 2027-06-30 |
Among the 107 studies in Shock with a site in France, from their registry updates:
This tab as a report to print or save as PDF → With an account.
The purpose of this study is to assess the hypothesis that, as compared to early intravenous feeding, early nutrition via the enteral route is associated with reduced Day 28-mortality in critically ill patients treated with mechanical ventilation and vasoactive drug.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Patients will receive parenteral nutrition during the first week of mechanical ventilation. After Day 3, the parenteral route may be switched to the enteral route if shock resolve (vasoactive drug stopped since 24 hours and serum lactate level \< 2 mmol/l). After Day 7, all patients will be fed via the enteral route.
Other: Parenteral nutrition
Patients will receive nutrition only via the enteral route during the firs week of invasive mechanical ventilation.
Other: Enteral nutrition
Also known as: Enteral feeding
Also known as: Intravenous nutrition, intravenous feeding
Mortality
Time frame: 28 days
Mortality Rate
Time frame: 90 days
Ventilator-associated Pneumonia Rate
Time frame: until weaning of mechanical ventilation (average: 7 days)
Nosocomial Infections Rate
Bloodstream infection Urinary tract infection Catheter-related infection Other infections
Time frame: until discharge from ICU (average: 10 days)
Length of Stay in Intensive Care Unit (ICU)
Time frame: until discharge from ICU (average: 10 days)
Length of Stay in Hospital
Time frame: until discharge from hospital (average: 17 days)
Variations in Sepsis-related Organ Failure Assessment (SOFA) Score
Time frame: first week (7 days) of mechanical ventilation
Calories Intake
Time frame: until weaning of mechanical ventilation (average : 7 days)
Proportion of Patients Given 100% of the Calorie Target
Time frame: until weaning of mechanical ventilation (average: 7 days)
Cumulative Calorie Deficit From Day 0 to Day 7
Time frame: During the first week (7 days) of mechanical ventilation
Hospital Mortality Rate
Time frame: Until discharge from hospital (average : 17 days)
Intensive Care Unit (ICU) Mortality Rate
Time frame: until discharge from ICU (average: 10 days)
Acute Bowel Ischemia Rate
Time frame: until weaning of mechanical ventilation (average: 7 days)
Vomiting Rate
Time frame: until weaning of mechanical ventilation (average: 7 days)
| Milestone | Parenteral Nutrition | Enteral Nutrition |
|---|---|---|
| Started | 1208 | 1202 |
| Completed | 1208 | 1202 |
| Not completed | 0 | 0 |
| Participants | Parenteral Nutrition | Enteral Nutrition |
|---|---|---|
| Mortality | 422 | 443 |
| Participants | Parenteral Nutrition | Enteral Nutrition |
|---|---|---|
| Mortality Rate | 507 | 530 |
Results for this outcome have not been posted.
Bloodstream infection Urinary tract infection Catheter-related infection Other infections
Results for this outcome have not been posted.
Results for this outcome have not been posted.
Results for this outcome have not been posted.
Results for this outcome have not been posted.
Results for this outcome have not been posted.
Results for this outcome have not been posted.
Results for this outcome have not been posted.
Results for this outcome have not been posted.
Results for this outcome have not been posted.
Results for this outcome have not been posted.
Results for this outcome have not been posted.
Non-serious events are listed at a 5% frequency threshold.
| Group | Deaths | Serious | Other |
|---|---|---|---|
| Parenteral Nutrition | — | 0/1,208 (0%) | 0/1,208 (0%) |
| Enteral Nutrition | — | 0/1,202 (0%) | 0/1,202 (0%) |
| Age, Continuous(years) | Parenteral Nutrition | Enteral Nutrition | Total |
|---|---|---|---|
| Mean | 66 ± 14 | 66 ± 14 | 66 ± 14 |
| Sex: Female, Male(Participants) | Parenteral Nutrition | Enteral Nutrition | Total |
|---|---|---|---|
| Female | 815 | 809 | 1624 |
| Male | 393 | 393 | 786 |
| Race and Ethnicity Not Collected(Participants) | Parenteral Nutrition | Enteral Nutrition | Total |
|---|---|---|---|
| Count of participants | — | — | 0 |
| Region of Enrollment(participants) | Parenteral Nutrition | Enteral Nutrition | Total |
|---|---|---|---|
| France | 1208 | 1202 | 2410 |
PDFs hosted by the registry, ClinicalTrials.gov.
Ran from Mar 2013 to primary completion in Jul 2015, 28 months.
Results were first posted in Jan 2026, 10 years 6 months after primary completion.
Of 67 non-industry interventional studies with no phase under Shock, half reached primary completion within 22 months of starting (the median), counting those still running; a quarter within 8 and three quarters within 38. This study's 28 months is above that.
Counting every sponsor, half of 70 studies reached it within 25 months; a quarter within 8 and three quarters within 43.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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Centre Hospitalier Departemental Vendee