An interventional study of IPT-AST and Group Counseling in Depression, sponsored by Children's Hospital of Philadelphia. Completed at 2 sites in United States. Open to participants aged 12 Years to 17 Years. Per ClinicalTrials.gov, last updated 2021-04-08.
Sponsored by Children's Hospital of Philadelphia · Not applicable, Interventional, and Prevention
This study is a randomized controlled trial comparing Interpersonal Psychotherapy-Adolescent Skills Training (IPT-AST) to group counseling (GC) for the prevention of depression in adolescents. The project will: (1) identify adolescents with elevated depressive symptoms but who do not meet criteria for a current mood disorder diagnosis; (2) randomize eligible adolescents to either IPT-AST (N = 100) or GC (N = 100); (3) assess depressive symptoms, depressive disorders, global functioning, interpersonal functioning, comorbid conditions and school related indices at baseline, mid-intervention, post-intervention, and at 6-, 12-, 18-, and 24-month follow-up; (4) examine the effects of IPT-AST on depression and various domains of functioning at each time point; and (5) conduct analyses to examine potential mediators and moderators of the association between IPT-AST and depression outcomes. This study will yield data on the efficacy of IPT-AST relative to GC for the prevention of depressive symptoms and depressive disorders. It will also provide information about the mechanisms of action of IPT-AST and determine for whom IPT-AST is most effective.
8,055 studies on the registry are indexed under Depression; 1,643 are open to participants now.
This study's enrollment of 185 is above the median of 84 across 6,718 interventional studies indexed under Depression.
Browse Depression studies →Children's Hospital of Philadelphia is the lead sponsor of 480 studies on the registry; 85 are open to participants now.
Of its 28 completed or terminated interventional studies of FDA-regulated products, 22 (79%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Interpersonal Psychotherapy-Adolescent Skills Training
Behavioral: IPT-AST
Group Counseling
Behavioral: Group Counseling
A school-based group prevention program that includes 2 individual pre-group sessions, 8 weekly 90 minute group sessions, an individual mid-group session and 4 booster sessions
Also known as: Interpersonal Psychotherapy-Adolescent Skills Training
Usual group counseling as delivered by school counselors; 1 pre-group session, 1 mid-group session, 8 90-minute group sessions, 4 booster sessions
Also known as: Usual group counseling
Presence of a Major Depressive Episode, Dysthymia or Depressive Disorder Not Otherwise Specified (NOS) on the Schedule for Affective Disorders for School Aged Children - Present and Life Time Version (K-SADS-PL)
Presence of a depression diagnosis as measured by a semi-structured diagnostic evaluation
Time frame: Post intervention (approximately 3 months post baseline)
Presence of a Major Depressive Episode, Dysthymia or Depressive Disorder NOS on the K-SADS-PL
Time frame: 6-months post-intervention
Presence of a Major Depressive Episode, Dysthymia or Depressive Disorder NOS on the K-SADS-PL
Time frame: 12-months post-intervention
Presence of a Major Depressive Episode, Dysthymia or Depressive Disorder NOS on the K-SADS-PL
Time frame: 18-months post-intervention
Presence of a Major Depressive Episode, Dysthymia or Depressive Disorder NOS on the K-SADS-PL
Time frame: 24-months post-intervention
Children's Depression Rating Scale-Revised (CDRS-R)
Scores on the CDRS-R
Time frame: Post intervention (approximately 3 months after baseline)
Children's Depression Rating Scale-Revised
Time frame: 6-months post-intervention
Children's Depression Rating Scale-Revised
Time frame: 12-months post-intervention
Children's Depression Rating Scale-Revised
Time frame: 18-months post-intervention
Children's Depression Rating Scale-Revised
Time frame: 24 months post-intervention
Children's Global Assessment Scale (CGAS)
Assesses global functioning
Time frame: Post intervention (approximately 3 months following baseline)
Children's Global Assessment Scale
Time frame: 6-months post-intervention
Children's Global Assessment Scale
Time frame: 12-months post-intervention
Children's Global Assessment Scale
Time frame: 18-months post-intervention
Children's Global Assessment Scale
Time frame: 24-months post-intervention
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This study is completed, as verified in Apr 2021. You cannot join it, but the record below documents what was studied.
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Children's Hospital of Philadelphia