An observational study in Angina Pectoris and Coronary Heart Disease, sponsored by University of Edinburgh. Terminated at 2 sites in United Kingdom. Per ClinicalTrials.gov, last updated 2014-12-02.
Sponsored by University of Edinburgh · Observational
The purpose of this study is to identify whether exposure to ambient levels of air pollution during normal daily activities has a functional impact on patients with coronary heart disease
Exposure to air pollution has been shown in epidemiological studies to be closely linked to cardiovascular morbidity and mortality. The exact components of air pollution that underlie the cardiovascular effects are not yet known, but combustion-derived particulate matter is suspected to be the major cause. In controlled exposure studies, we have recently demonstrated that exposure to diesel exhaust causes increased myocardial ischaemia with exercise in patients with asymptomatic coronary artery disease. The mechanism behind this effect is not yet understood, but we have shown that diesel exhaust exposure causes an acute impairment of two important and highly relevant aspects of vascular tone: vasomotor tone and endogenous fibrinolysis. In this study we propose to investigate the effects of exposure to ambient levels of air pollution on patients with stable, symptomatic angina pectoris, during their daily lives.
3,639 studies on the registry are indexed under Heart Diseases; 461 are open to participants now.
This study's enrollment of 1 is below the median of 294 across 1,241 observational studies indexed under Heart Diseases.
Browse Heart Diseases studies →University of Edinburgh is the lead sponsor of 393 studies on the registry; 64 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients with stable angina pectoris and documented coronary artery disease
Exclusion Criteria:
Patients with stable angina pectoris and documented coronary heart disease recruited in Edinburgh
Patients with stable angina pectoris and documented coronary heart disease recruited in London
Symptoms of angina pectoris - assessed by symptom diary and reliever medication usage
Time frame: Throughout study period
Myocardial ischaemic burden - assessed using 12-lead continuous Holter ECG monitoring
Time frame: Throughout study period
Time to 1mm ST segment depression during standard BRUCE exercise stress testing
Time frame: At the end of the study period
Total exercise capacity - measured using GPS tracking of activity completed
Time frame: Throughout study period
Exercise capacity - determined by standard BRUCE exercise stress testing
Time frame: Immediately after study period
Ambulatory blood pressure
Time frame: Throughout study period
Biochemical evidence of myocardial ischaemia - highly sensitive troponin, ischaemically modified albumin and fatty acid binding protein
Time frame: Before and after study period
This study is terminated, as verified in Dec 2014. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
University of Edinburgh