An interventional study of morphine in Analgesia, sponsored by Federal University of São Paulo. Completed at 1 site in Brazil. Open to participants aged 50 Years to 90 Years. Per ClinicalTrials.gov, last updated 2008-03-14.
Sponsored by Federal University of São Paulo · Not applicable, Interventional, and Treatment
CONTEXT AND OBJECTIVE: Osteoarthritis causes pain and disability in a high percentage of elderly people. The aim of the present study was to compare the analgesic effect of intra-articular bupivacaine and morphine in patients with knee osteoarthritis.
DESIGN AND SETTING: A randomized and double-blind study was performed at a Pain Clinic of São Paulo Federal University.
METHODS: Thirty-nine patients with pain for more than 3 months and an intensity higher than 3 on a numerical scale (zero to 10) were included. G1 patients received 1 mg (1 ml) morphine diluted in 9 ml saline by the intra-articular route, and G2 patients received 25 mg (10 ml) 0.25% bupivacaine without epinephrine. Pain was assessed on a numerical scale and knee flexion and extension angles were measured after administration of the drugs at rest and during movement. The total amount of analgesic complementation with 500 mg paracetamol was also determined.
Among the 39 patients selected, two patients from group 1 and five from group 2 were excluded from some of the analyses because they did not return on the day of assessment or because they used a complementary analgesic different from that standardized in the study
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This study's enrollment of 30 is below the median of 75 across 1,089 interventional studies indexed under Agnosia.
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Exclusion Criteria:
G1 patients received morphine intra-articular route G2 patients received bupivacaine without epinephrine.
Drug: morphine
1 mg (1 ml) morphine diluted in 9 ml saline by the intra-articular route, and 25 mg (10 ml) 0.25% bupivacaine without epinephrine.
Also known as: dimorf
Pain relief
Time frame: 1 year
bupivacaine and morphine
Time frame: 1 year
This study is completed, as verified in Mar 2008. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Morphine
Federal University of São Paulo →