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RecruitingNCT07765095Updated Aug 14, 2026

Pericapsular Nerve Group (PENG) Block on Postoperative Pain Management After Acetabular Fracture Fixation

An interventional study of Pericapsular nerve group (PENG) block in Acetabular Fractures, sponsored by University of Puerto Rico. Recruiting at 1 site in Puerto Rico. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-08-14.

Sponsored by University of Puerto Rico · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
70
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

The goal of this clinical trial is to find out whether a Pericapsular Nerve Group (PENG) block, a type of nerve block used to control pain, can reduce pain after surgery in adults with an acetabular (hip socket) fracture who are undergoing surgical repair. The study will also evaluate the safety of the PENG block.

The main questions this study aims to answer are:

Does a PENG block reduce pain after surgery? Does a PENG block reduce the need for opioid pain medications after surgery? Are there any side effects or complications related to the PENG block? Researchers will compare patients who receive a PENG block with patients who do not receive a PENG block to determine whether the block improves pain control after surgery.

Participants will:

Be randomly assigned to receive either a PENG block or no PENG block before surgery while under general anesthesia.

Undergo surgery to repair their acetabular fracture. Receive the same standard pain medications after surgery. Be asked to rate their pain at several time points after surgery using a standard pain scale.

Have their use of pain medications, recovery, and any side effects recorded during their hospital stay and follow-up.

02

Conditions studied

  • Acetabular Fractures

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Keywords

  • Acetabular Fractures
  • Pain Management
  • Pericapsular Nerve Group (PENG)
  • Open Reduction and Internal Fixation (ORIF)
  • Regional Block
03

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Patient age 18 years or older
  • Acetabular Fracture amenable to surgery through the Kocher-Langenbeck approach
  • Full weight-bearing capacity prior to the trauma
  • Providing written informed consent

Exclusion criteria

Exclusion Criteria:

  • Age less than 18 years old
  • Fracture pattern not amenable to surgery through Kocher-Langenbeck approach
  • Lower extremity fracture ipsilateral to the acetabular fracture
  • Any traumatic injury that requires surgical management by other surgical specialty
  • Bilateral Acetabular Fractures
  • Limited weight bearing capacity prior to the trauma
  • Procedure performed under any anesthesia other than GETA
  • Chronic opioid use
  • History of Substance Abuse
  • Allergies or history of adverse reactions to any of the drugs used in the
  • Mental Disability
  • History of Psychiatric disorders
04

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Outcomes assessor)
Enrollment
70 participants (estimated)

Study arms

  • Experimental
    PENG Block Group

    This group includes participants who will receive the pericapsular nerve group (PENG) block after surgical intervention.

    Procedure: Pericapsular nerve group (PENG) block

  • No intervention
    NO PENG Block Group

    This group includes participants who will not receive the pericapsular nerve group (PENG) block after surgical intervention and will be considered our control group.

Interventions

  • ProcedurePericapsular nerve group (PENG) block

    PENG Block is a regional block technique well documented in the literature for certain orthopedic injuries and interventions. However, the efficacy of this intervention on acetabular fracture fixation has not been well studied or addressed in previous literature.

05

What researchers measure

Primary outcomes

  1. Numeric Pain Rating Scale (NPRS)

    The NPRS is an 11-point scale scored from 0-10, with " 0 " representing no pain and "10" being the most intense pain experienced. Patients verbally select a value that is most in line with the intensity of pain that they have experienced at each time point under evaluation.

    Time frame: From surgery to 48 hours after surgery (12 hour Intervals)

Secondary outcomes

  1. Morphine Miligram Equivalent (MME)

    MME is the total amount of an opioid drug converted to an equivalent strength of oral morphine. This measure is used to track the consumption of opioids in a standardized, uniform way.

    Time frame: From surgery to 48 hours after surgery (12 hour Intervals)

  2. Time to first opioid dose

    Will measure in minutes the time that patient spent without consuming opioids before requesting their first rescue therapy (opioid) dose.

    Time frame: From surgery to 48 hours after surgery (Will quantify from surgery to time of administration)

  3. Postoperative Complications

    Inpatient complications are unforeseen medical issues that arise during a hospital stay, potentially extending recovery time or requiring additional treatment.

    Time frame: From surgery to 48 hours after surgery

06

Study locations

1 of 1 sites recruiting
  • Puerto Rico Medical Center
    San Juan, 00935, Puerto Rico
    • Luis Lojo-Sojo, MD · Contact · luis.lojo@upr.edu · 787773535
    • Luis Lojo Sojo, MD · Principal investigator
    • Norberto J Torres Lugo, MD · Sub investigator
    Recruiting
07

References and documents

Individual participant data

Plan to share: Yes — Data will be stored in an encrypted digital file and made available for file sharing upon a valid request.

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT07765095
Lead sponsor
University of Puerto Rico
Responsible party
Sponsor
First posted
Aug 14, 2026
Start date
Sep 8, 2025
Primary completion
Jan 30, 2027 (estimated)
Completion
Mar 30, 2027 (estimated)
Last update
Aug 14, 2026

Study contacts

Luis Lojo Sojo, MD
principal investigator · University of Puerto Rico

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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