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Not yet recruitingNCT07891013Updated Oct 23, 2026

Posterior Pericapsular Deep-gluteal Block

An interventional study of PENG (Pericapsular nerve group) block and LFCN (Lateral femoral cutaneous nerve) block in Pain, Postoperative, sponsored by Ankara Etlik City Hospital. Not yet recruiting. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-23.

Sponsored by Ankara Etlik City Hospital · Not applicable, Interventional, and Supportive care

Updated Oct 23, 2026Newly registeredGo to Updates ↓
Phase
Not applicable
Study type
Interventional
Enrollment
60
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

The goal of this clinical trial is to determine whether adding a posterior pericapsular deep-gluteal (PPD) block to pericapsular nerve group (PENG) and lateral femoral cutaneous nerve (LFCN) blocks improves pain control after total hip arthroplasty.

The main questions it aims to answer are:

  • Does adding a posterior pericapsular deep-gluteal block reduce clinically significant pain during movement in the early postoperative period?
  • Does adding this block reduce postoperative pain and opioid requirements?
  • Does adding this block improve functional recovery after surgery?

Researchers will compare patients receiving PENG and LFCN blocks with patients receiving PENG and LFCN blocks plus a posterior pericapsular deep-gluteal block to determine whether blocking the posterior region of the hip provides additional pain relief.

Participants will:

  • Receive ultrasound-guided nerve blocks before surgery according to their assigned study group.
  • Undergo total hip arthroplasty under spinal anesthesia.
  • Have their pain assessed at predefined times after surgery, including during movement.
  • Be evaluated for opioid requirements and functional recovery after surgery.
Read the detailed description

Total hip arthroplasty is commonly associated with moderate to severe postoperative pain. Providing effective analgesia can be challenging because of the complex innervation of the hip joint, and no single nerve block or combination of blocks has been demonstrated to be superior for all types of hip surgery.

The pericapsular nerve group (PENG) block and lateral femoral cutaneous nerve (LFCN) block are regional anesthesia techniques used to reduce pain after hip surgery. However, these blocks mainly target the anterior and lateral regions of the hip and may not adequately cover pain arising from the posterior region.

The posterior pericapsular (deep-gluteal) block (PPD) is a recently described regional anesthesia technique designed to target the nerves supplying the posterior region of the hip while preserving motor function. Evidence regarding the additional analgesic benefit of this block in patients undergoing total hip arthroplasty remains limited.

This randomized controlled study will compare patients receiving PENG and LFCN blocks with patients receiving PENG and LFCN blocks combined with PPD block. The primary aim is to determine whether adding the posterior pericapsular (deep-gluteal) block reduces clinically significant pain during movement in the early postoperative period. The study will also evaluate postoperative pain, opioid consumption, and quality of functional recovery.

The investigators hypothesize that adding the posterior pericapsular (deep-gluteal) block to PENG and LFCN blocks will provide better early postoperative analgesia than PENG and LFCN blocks alone.

02

Conditions studied

  • Pain, Postoperative

Keywords

  • total hip arthroplasty
  • analgesia
  • pain
  • pericapsular nerve group (PENG) block
  • posterior pericapsular deep gluteal block
  • lateral femoral cutaneous (LFCN) block
  • regional anesthesia
03

In context

Pain, Postoperative

5,224 studies on the registry are indexed under Pain, Postoperative; 1,154 are open to participants now.

This study's planned enrollment of 60 is below the median of 75 across 4,457 interventional studies indexed under Pain, Postoperative.

Browse Pain, Postoperative studies →

Lead sponsor

Ankara Etlik City Hospital is the lead sponsor of 172 studies on the registry; 77 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Patients aged 18 years or older
  • Patients scheduled for elective primary unilateral total hip arthroplasty
  • American Society of Anesthesiologists (ASA) physical status I-III
  • Patients who provide written informed consent to participate in the study

Exclusion criteria

Exclusion Criteria:

  • Cognitive impairment that may interfere with pain assessment or study participation
  • Known allergy to local anesthetics
  • Revision total hip arthroplasty
  • Contraindication to spinal anesthesia
  • Neuromuscular disease
05

Study design

Phase
Not applicable
Primary purpose
Supportive care
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Outcomes assessor)
Enrollment
60 participants (estimated)

Study arms

  • Active comparator
    PENG+LFCN group

    PENG block : 20 ml %0.25 Bupivacaine LFCN block: 5 ml %0.50 Bupivacaine

    Procedure: PENG (Pericapsular nerve group) block · Procedure: LFCN (Lateral femoral cutaneous nerve) block

  • Experimental
    PENG+LFCN+PPD group

    PENG block: 20 ml %0.25 Bupivacaine LFCN block: 5 ml %0.50 Bupivacaine PPD block: 15 ml %0.25 Bupivacaine

    Procedure: PENG (Pericapsular nerve group) block · Procedure: LFCN (Lateral femoral cutaneous nerve) block · Procedure: PPD (Posterior pericapsular deep gluteal) block

Interventions

  • ProcedurePENG (Pericapsular nerve group) block

    An ultrasound-guided pericapsular nerve group (PENG) block will be performed in the preoperative period, approximately 30 minutes before surgery.

  • ProcedureLFCN (Lateral femoral cutaneous nerve) block

    An ultrasound-guided lateral femoral cutaneous nerve (LFCN) block will be performed in the preoperative period, approximately 30 minutes before surgery.

  • ProcedurePPD (Posterior pericapsular deep gluteal) block

    An ultrasound-guided posterior pericapsular deep-gluteal block will be performed in the preoperative period, approximately 30 minutes before surgery.

06

What researchers measure

Primary outcomes

  1. 6-hour dynamic pain intensity

    Dynamic pain will be assessed using the Numerical Rating Scale (NRS), ranging from 0 (no pain) to 10 (worst imaginable pain).

    Time frame: 6 hours postoperatively

Secondary outcomes

  1. Dynamic pain intensity

    Dynamic pain will be assessed using the Numerical Rating Scale (NRS), ranging from 0 (no pain) to 10 (worst imaginable pain).

    Time frame: 4, 8, 12, and 24 hours postoperatively

  2. Pain intensity at rest

    Resting pain will be assessed using the Numerical Rating Scale (NRS), ranging from 0 (no pain) to 10 (worst imaginable pain).

    Time frame: 4, 6, 8, 12, and 24 hours postoperatively

  3. Cumulative morphine consumption

    The cumulative amount of morphine consumed during the first 24 hours postoperatively will be recorded in milligrams (mg).

    Time frame: Up to 24 hours postoperatively

  4. Time to first rescue analgesic

    The time from the end of surgery to the first pain score ≥ 4 at rest or during movement, or to the first patient request for analgesia, will be recorded in hours.

    Time frame: Up to 24 hours postoperatively

  5. Quality of Recovery (QoR)-15 score

    Quality of postoperative recovery will be assessed using the 15-item Quality of Recovery (QoR-15) questionnaire. The total score ranges from 0 to 150, with higher scores indicating better quality of recovery.

    Time frame: Preoperatively and postoperative day 1

Other outcomes

  1. Patient satisfaction score

    Patient satisfaction with postoperative pain management will be assessed using a numerical rating scale ranging from 0 (completely dissatisfied) to 10 (completely satisfied), with higher scores indicating greater satisfaction.

    Time frame: Postoperative day 1

  2. Sleep quality score

    Sleep quality during the first postoperative night will be assessed using a 5-point numerical rating scale ranging from 1 (very poor) to 5 (very good), with higher scores indicating better sleep quality.

    Time frame: Postoperative day 1

07

Study locations

No study locations are listed for this record.

08

References and documents

Publications

  • Hu J, Wang Q, Hu J, Gong C, Yang J. A modified hip pericapsular nerve block on postoperative pain and functional outcome after total hip arthroplasty: a prospective, double-blind, randomized controlled study. Korean J Anesthesiol. 2025 Aug;78(4):351-360. doi: 10.4097/kja.24593. Epub 2025 Mar 13. PubMed 40075241 ↗
  • Wu H, Li J, Li N, Zhang S, Duan L. Injectate spread following posterior hip pericapsular block: a preliminary single-case anatomical observation in a formalin-fixed cadaver. Front Pain Res (Lausanne). 2026 May 29;7:1867189. doi: 10.3389/fpain.2026.1867189. eCollection 2026. PubMed 42293426 ↗
  • Lee KH, Wang JC, Chang CY, Teng WN, Wang HY, Lee CC, Tsai SW, Chen CF, Wu PK, Chen WM. Regional anaesthesia modalities for primary total hip arthroplasty: a systematic review and component network meta-analysis. Br J Anaesth. 2025 Aug;135(2):469-482. doi: 10.1016/j.bja.2025.04.019. Epub 2025 Jun 6. PubMed 40483183 ↗
  • Vermeylen K, Van Aken D, Versyck B, Casaer S, Bleys R, Bracke P, Groen G. Deep posterior gluteal compartment block for regional anaesthesia of the posterior hip: a proof-of-concept pilot study. BJA Open. 2023 Feb 15;5:100127. doi: 10.1016/j.bjao.2023.100127. eCollection 2023 Mar. PubMed 37587997 ↗
  • Cardoso FA, Fortuna-Costa A, Garcia LV. Analgesic effect of lateral femoral cutaneous nerve block added to the pericapsular nerve group (PENG) block in primary total hip arthroplasty: a randomized clinical trial. Minerva Anestesiol. 2025 Jan-Feb;91(1-2):26-35. doi: 10.23736/S0375-9393.24.18141-2. Epub 2024 Dec 4. PubMed 39630141 ↗

Individual participant data

Plan to share: No

09

Updates

1 registry update since Sep 25, 2026
Registered
First appeared on the registry. No changes since
Oct 23, 2026
Show all 1 update
  1. Oct 23, 2026
    First appeared on the registry

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT07891013
Responsible party
Fatma Özkan Sipahioğlu (Principal investigator, Ankara Etlik City Hospital) — Principal investigator
First posted
Oct 23, 2026
Start date
Oct 20, 2026 (estimated)
Primary completion
Dec 20, 2026 (estimated)
Completion
Dec 30, 2026 (estimated)
Last update
Oct 23, 2026

Study contacts

Fatma Ozkan Sipahioglu, MD
Contact
ftmozkan_uzmdr@yahoo.com
+905531362875
Funda Atar, MD
Contact
fundaatar81@gmail.com
+905064927432
Fatma Ozkan Sipahioglu, MD
principal investigator · Ankara Etlik City Hospital

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.

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