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CompletedNCT00628524HCSUpdated Dec 2, 2025

Homburg Cream & Sugar Study

An observational study in Coronary Artery Disease, Diabetes and Metabolic Syndrome, sponsored by Universität des Saarlandes. Completed at 1 site in Germany. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-12-02.

Sponsored by Universität des Saarlandes · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
514
Ages
18 Years and older
Sex
All
01

Study summary

The purpose of this study is to prospectivly analyze the correlation of triglyceride tolerance and glucose tolerance with cardiovascular morbidity and mortality in patients with stable coronary artery disease within 18 months and to determine, whether measurement of triglyceride tolerance can discriminate patients at risk for cardiovascular events.

02

Conditions studied

  • Coronary Artery Disease
  • Diabetes
  • Metabolic Syndrome
  • Glucose Tolerance
  • Hyperlipidemia
03

In context

Coronary Artery Disease

5,598 studies on the registry are indexed under Coronary Artery Disease; 957 are open to participants now.

This study's enrollment of 514 is above the median of 336 across 1,947 observational studies indexed under Coronary Artery Disease.

Browse Coronary Artery Disease studies →

Lead sponsor

Universität des Saarlandes is the lead sponsor of 64 studies on the registry; 16 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

> 500 consecutive patients with stable coronary artery disease being treated in the cardiology department of the university hospital.

Inclusion criteria

  • Stable CAD

Exclusion criteria

Exclusion Criteria:

  • Acute Coronary Syndrom
  • Relevant Arrhythmias
  • Severe valvular heart disease
  • Decompensated heart failure
  • Severe inflammtory disease (infectious, rheumatoid)
  • Metabolic diseases (e.g. thyroid)
  • Inability to swallow
  • Liver or kidney failure
  • Lactose intolerance
  • Fat intolerance (e.g. chronic pancreatitis, gall stones)
  • Malignant Disease
  • Psychiatric Diseases (including alcohol / drug abuse)
  • Pregnancy
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
514 participants (actual)
Biospecimen retention
Samples without dna

Groups and cohorts

  • 1

    \> 500 consecutive patients with coronary artery disease fulfilling eligibility criteria.

06

What researchers measure

Primary outcomes

  1. Parameters of triglyceride tolerance and glucose tolerance in correlation to cardiovascular events, cardiovascular mortality, total mortality.

    Time frame: 48 months after inclusion.

Secondary outcomes

  1. Waist-to-Hip ratio, nutrition protocol, physical activity, non-invasive endothelial function, body fat composition, other biomarkers of lipid and glucose metabolism.

    Time frame: Directly after inclusion.

07

Study locations

1 site
  • University Hospital Homburg / Saar - Cardiology Department
    Homburg, Saarland 66421, Germany
08

References and documents

Publications

  • Werner C, Filmer A, Fritsch M, Groenewold S, Graber S, Bohm M, Laufs U. Risk prediction with triglycerides in patients with stable coronary disease on statin treatment. Clin Res Cardiol. 2014 Dec;103(12):984-97. doi: 10.1007/s00392-014-0740-0. Epub 2014 Jul 11. PubMed 25012240 ↗
  • Katzmann JL, Werner CM, Stojakovic T, Marz W, Scharnagl H, Laufs U. Apolipoprotein CIII predicts cardiovascular events in patients with coronary artery disease: a prospective observational study. Lipids Health Dis. 2020 May 30;19(1):116. doi: 10.1186/s12944-020-01293-9. PubMed 32473635 ↗
  • Hoffmann MM, Werner C, Bohm M, Laufs U, Winkler K. Association of secreted frizzled-related protein 4 (SFRP4) with type 2 diabetes in patients with stable coronary artery disease. Cardiovasc Diabetol. 2014 Nov 19;13:155. doi: 10.1186/s12933-014-0155-2. PubMed 25408147 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 2, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT00628524
Lead sponsor
Universität des Saarlandes
Responsible party
Sponsor
First posted
Mar 5, 2008
Start date
Feb 2008
Primary completion
Jul 2013
Completion
Aug 2013
Last update
Dec 2, 2025

Study contacts

Ulrich Laufs, MD
principal investigator · University Hospital, Saarland

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Dec 2013. You cannot join it, but the record below documents what was studied.

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