ClinicalTrials.gg
RecruitingNCT03381794Updated Apr 27, 2026

The German Keratoplasty Registry of the German Ophthalmological Society (DOG)

An observational study in Corneal Transplantation, sponsored by Universität des Saarlandes. Recruiting at 1 site in Germany. Open to participants aged 1 Year to 100 Years. Per ClinicalTrials.gov, last updated 2026-04-27.

Sponsored by Universität des Saarlandes · Observational

From the registry’s dates

  • Started Jan 2001; still recruiting 25 years 10 months later.
Study type
Observational
Model
Cohort
Time perspective
Other
Enrollment
100,000
Ages
1 Year to 100 Years
Sex
All
01

Study summary

Aim of this study is to reflect on the changing trends in absolute numbers, surgical techniques and indications of corneal transplantations being performed in Germany.

The Section Cornea of the German Ophthalmological Society provides interim-assessments on a regular basis about the most up-to-date results of this long-term study.

02

Conditions studied

  • Corneal Transplantation

Keywords

  • Keratoplasty Registry, PKP, DSAEK, DMEK, DALK
03

In context

Lead sponsor

Universität des Saarlandes is the lead sponsor of 68 studies on the registry; 17 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
1 Year to 100 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

All patients in Germany treated with the different types of corneal transplantation since 2001.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

All patients in Germany treated with the different types of corneal transplantation since 2001.

Exclusion criteria

Exclusion Criteria:

Patients without corneal transplantation.

05

Study design

Observational model
Cohort
Time perspective
Other
Enrollment
100,000 participants (estimated)
Target follow-up
16 Years
Patient registry
Yes

Groups and cohorts

  • Patients with corneal transplantation

    Aim is to include all patients in Germany treated with the different types of corneal transplantation.

    Procedure: Corneal transplantation

Interventions

  • ProcedureCorneal transplantation

    PKP: Penetrating Keratoplasty DALK: Deep Anterior Lamellar Keratoplasty DMEK: Descemet Membrane Endothelial Keratoplasty DSAEK: Descemet's Stripping Automated Endothelial Keratoplasty

    Also known as: PKP, DALK, DMEK, DSAEK

06

What researchers measure

Primary outcomes

  1. An overview about absolute numbers of corneal transplantation in Germany.

    A questionnaire about absolute numbers of corneal transplantation per year was sent to the 111 ophthalmological departments in Germany performing corneal transplantation. Data has been and is collected annually since 2001.

    Time frame: 01/01/2001 to 31/12/2031

  2. An overview about trends in the various types of corneal transplantation in Germany.

    The questionnaire also records the types of corneal transplantation (i.e. penetrating keratoplasty, deep anterior lamellar keratoplasty, Descemet membrane endothelial keratoplasty (DMEK) and Descemet's stripping automated endothelial keratoplasty DSAEK) allowing a discussion of trends in corneal transplantation. Data has been and is collected annually since 2001.

    Time frame: 01/01/2001 to 31/12/2031

  3. An overview about indications for corneal transplantation in Germany.

    The questionnaire also records the indications for corneal transplantation (e.g. Fuchs' endothelial corneal dystrophy, pseudophakic corneal decompensation, repeated keratoplasty after graft failure, keratoconus and corneal scarring). Data has been and is collected annually since 2001.

    Time frame: 01/01/2001 to 31/12/2031

07

Study locations

1 of 1 sites recruiting
08

References and documents

Publications

  • Flockerzi E, Turner C, Seitz B, Collaborators GSG; GeKeR Study Group. Descemet's membrane endothelial keratoplasty is the predominant keratoplasty procedure in Germany since 2016: a report of the DOG-section cornea and its keratoplasty registry. Br J Ophthalmol. 2024 May 21;108(5):646-653. doi: 10.1136/bjo-2022-323162. PubMed 37586835 ↗
  • Flockerzi E, Maier P, Bohringer D, Reinshagen H, Kruse F, Cursiefen C, Reinhard T, Geerling G, Torun N, Seitz B; all German Keratoplasty Registry Contributors. Trends in Corneal Transplantation from 2001 to 2016 in Germany: A Report of the DOG-Section Cornea and its Keratoplasty Registry. Am J Ophthalmol. 2018 Apr;188:91-98. doi: 10.1016/j.ajo.2018.01.018. Epub 2018 Feb 2. PubMed 29410297 ↗

Individual participant data

Plan to share: Undecided

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 27, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03381794
Lead sponsor
Universität des Saarlandes
Collaborators
University Eye Hospital, Freiburg, University of Erlangen-Nürnberg, University of Cologne, Heinrich-Heine University, Duesseldorf, Charite University, Berlin, Germany
Responsible party
Elias Flockerzi (Principal Investigator, Resident of Ophthalmology, University Hospital, Saarland) — Principal investigator
First posted
Dec 22, 2017
Start date
Jan 1, 2001
Primary completion
Jan 1, 2036 (estimated)
Completion
Jan 1, 2036 (estimated)
Last update
Apr 27, 2026

Study contacts

Elias Flockerzi, PD Dr.med.
Contact
elias.flockerzi@uks.eu
0049-6841-16-22302
Berthold Seitz, Prof.Dr.med.
Contact
berthold.seitz@uks.eu
0049-6841-16-22387
Berthold Seitz, Prof.Dr.med.
study director · Universität des Saarlandes

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Interested in this study?

Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.

Contact study team

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion