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TerminatedNCT00316576Updated Jan 17, 2008

Angiotensin-Converting Enzyme Polymorphism and Acute Renal Failure (ECAREA)

An observational study in Kidney Failure, Acute and Critical Illness, sponsored by University Hospital, Caen. Terminated at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2008-01-17.

Sponsored by University Hospital, Caen · Observational

Why this study was terminated
The study was stopped on november 2006 after inclusion was fulfilled
Study type
Observational
Time perspective
Prospective
Enrollment
160
Ages
18 Years and older
Sex
All
01

Study summary

Associations between angiotensin-converting enzyme gene polymorphism and occurrence and outcome of ARDS, and with respiratory complications post cardiopulmonary bypass have already been demonstrated. Based on physiological effects of angiotensin II, we hypothesized that the I allele of the angiotensin-converting enzyme Insertion/Deletion polymorphism may be associated with a higher risk of acute renal failure in critically ill patients.

Read the detailed description

Associations between angiotensin-converting enzyme gene polymorphism and occurrence and outcome of ARDS, and with respiratory complications post cardiopulmonary bypass have already been demonstrated. Based on physiological effects of angiotensin II, we hypothesized that the I allele of the angiotensin-converting enzyme Insertion/Deletion polymorphism may be associated with a higher risk of acute renal failure in critically ill patients.

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Conditions studied

  • Kidney Failure, Acute
  • Critical Illness

Keywords

  • Kidney failure, Acute
  • Genetic Polymorphism
  • Angiotensin-converting enzyme
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In context

Renal Insufficiency

1,995 studies on the registry are indexed under Renal Insufficiency; 173 are open to participants now.

This study's planned enrollment of 160 is close to the median of 149 across 394 observational studies indexed under Renal Insufficiency.

Browse Renal Insufficiency studies →

Lead sponsor

University Hospital, Caen is the lead sponsor of 505 studies on the registry; 80 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Consecutive patients admitted to ICU fore more than 48 hours

Inclusion criteria

  • Age > 18 yrs
  • ICU stay > 48 hours

Exclusion criteria

Exclusion Criteria:

  • Age \< 18 yrs
  • Creatinine > 180 µmol/L
  • Absence of consent
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Study design

Time perspective
Prospective
Enrollment
160 participants (estimated)

Interventions

  • ProcedureBlood sampling for PCR
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What researchers measure

Primary outcomes

  1. Incidence of ARF

    Time frame: During ICU stay

Secondary outcomes

  1. Mortality

    Time frame: ICU and Hospital mortality

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Study locations

1 site
  • Medical Intensive care Unit; Caen University Hospital
    Caen, 14000, France
08

References and documents

Publications

  • du Cheyron D, Fradin S, Ramakers M, Terzi N, Guillotin D, Bouchet B, Daubin C, Charbonneau P. Angiotensin converting enzyme insertion/deletion genetic polymorphism: its impact on renal function in critically ill patients. Crit Care Med. 2008 Dec;36(12):3178-83. doi: 10.1097/CCM.0b013e318186a299. PubMed 19020433 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 17, 2008, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00316576
Lead sponsor
University Hospital, Caen
First posted
Apr 21, 2006
Start date
May 2006
Completion
Nov 2006
Last update
Jan 17, 2008

Study contacts

Damien du Cheyron, MD
principal investigator · University Hospital, Caen
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is terminated, as verified in Jan 2008. You cannot join it, but the record below documents what was studied.

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